Comparison of HIV characteristics across 3 datasets: the Korea HIV/AIDS Cohort Study prospective, retrospective, and national reporting system
OBJECTIVES The Korea HIV/AIDS Cohort Study has been conducted prospectively for 18 years. However, it faces limitations in representing the entire population of patients with human immunodeficiency virus (HIV) in Korea. To address these limitations and validate the study design, we analyzed characte...
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Korean Society of Epidemiology
2024-06-01
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| Series: | Epidemiology and Health |
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| Online Access: | http://www.e-epih.org/upload/pdf/epih-46-e2024055.pdf |
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| author | Yunsu Choi Jun Yong Choi Bo Youl Choi Bo Young Park Shin-Woo Kim Joon Young Song Jung Ho Kim Sang Il Kim |
| author_facet | Yunsu Choi Jun Yong Choi Bo Youl Choi Bo Young Park Shin-Woo Kim Joon Young Song Jung Ho Kim Sang Il Kim |
| author_sort | Yunsu Choi |
| collection | DOAJ |
| description | OBJECTIVES The Korea HIV/AIDS Cohort Study has been conducted prospectively for 18 years. However, it faces limitations in representing the entire population of patients with human immunodeficiency virus (HIV) in Korea. To address these limitations and validate the study design, we analyzed characteristics across several HIV datasets. METHODS We compared epidemiological and clinical characteristics from 3 datasets: the Korea HIV/AIDS Cohort Study (dataset 1, n=1,562), retrospective cohort data (dataset 2, n=2,665), and the national HIV reporting system of the Korea Disease Control and Prevention Agency (KDCA) (dataset 3, n=17,403). RESULTS The demographic characteristics of age, sex, and age at HIV diagnosis did not differ significantly across datasets. However, dataset 3 contained a higher proportion of patients diagnosed after 2008 (69.5%) than the other datasets. Regarding transmission routes, same-sex contact accounted for a greater proportion of dataset 1 (59.8%) compared to datasets 2 (20.9%) and 3 (32.6%). The proportion of patients with CD4 T-cell counts below 200/mm3 at HIV diagnosis was higher in datasets 1 (39.4%) and 2 (33.3%) compared to dataset 3 (16.3%). Initial HIV viral load measurements were not obtained for dataset 3. CONCLUSIONS The Korea HIV/AIDS Cohort Study demonstrated representativeness regarding the demographic characteristics of Korean patients. Of the sources, dataset 1 contained the most data on transmission routes. While the KDCA data encompassed all HIV patients, it lacked detailed clinical information. To improve the representativeness of the Korea HIV/AIDS Cohort Study, we propose expanding and revising the cohort design and enrolling more patients who have been recently diagnosed. |
| format | Article |
| id | doaj-art-b032b9dd7d384000a15e2a7c6a5dbe1e |
| institution | OA Journals |
| issn | 2092-7193 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Korean Society of Epidemiology |
| record_format | Article |
| series | Epidemiology and Health |
| spelling | doaj-art-b032b9dd7d384000a15e2a7c6a5dbe1e2025-08-20T02:13:26ZengKorean Society of EpidemiologyEpidemiology and Health2092-71932024-06-014610.4178/epih.e20240551521Comparison of HIV characteristics across 3 datasets: the Korea HIV/AIDS Cohort Study prospective, retrospective, and national reporting systemYunsu Choi0Jun Yong Choi1Bo Youl Choi2Bo Young Park3Shin-Woo Kim4Joon Young Song5Jung Ho Kim6Sang Il Kim7 Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Internal Medicine, AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Department of Internal Medicine, AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea Division of Infectious Disease, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaOBJECTIVES The Korea HIV/AIDS Cohort Study has been conducted prospectively for 18 years. However, it faces limitations in representing the entire population of patients with human immunodeficiency virus (HIV) in Korea. To address these limitations and validate the study design, we analyzed characteristics across several HIV datasets. METHODS We compared epidemiological and clinical characteristics from 3 datasets: the Korea HIV/AIDS Cohort Study (dataset 1, n=1,562), retrospective cohort data (dataset 2, n=2,665), and the national HIV reporting system of the Korea Disease Control and Prevention Agency (KDCA) (dataset 3, n=17,403). RESULTS The demographic characteristics of age, sex, and age at HIV diagnosis did not differ significantly across datasets. However, dataset 3 contained a higher proportion of patients diagnosed after 2008 (69.5%) than the other datasets. Regarding transmission routes, same-sex contact accounted for a greater proportion of dataset 1 (59.8%) compared to datasets 2 (20.9%) and 3 (32.6%). The proportion of patients with CD4 T-cell counts below 200/mm3 at HIV diagnosis was higher in datasets 1 (39.4%) and 2 (33.3%) compared to dataset 3 (16.3%). Initial HIV viral load measurements were not obtained for dataset 3. CONCLUSIONS The Korea HIV/AIDS Cohort Study demonstrated representativeness regarding the demographic characteristics of Korean patients. Of the sources, dataset 1 contained the most data on transmission routes. While the KDCA data encompassed all HIV patients, it lacked detailed clinical information. To improve the representativeness of the Korea HIV/AIDS Cohort Study, we propose expanding and revising the cohort design and enrolling more patients who have been recently diagnosed.http://www.e-epih.org/upload/pdf/epih-46-e2024055.pdfcohort studiesselection biasresearch designhivacquired immunodeficiency syndrome |
| spellingShingle | Yunsu Choi Jun Yong Choi Bo Youl Choi Bo Young Park Shin-Woo Kim Joon Young Song Jung Ho Kim Sang Il Kim Comparison of HIV characteristics across 3 datasets: the Korea HIV/AIDS Cohort Study prospective, retrospective, and national reporting system Epidemiology and Health cohort studies selection bias research design hiv acquired immunodeficiency syndrome |
| title | Comparison of HIV characteristics across 3 datasets: the Korea HIV/AIDS Cohort Study prospective, retrospective, and national reporting system |
| title_full | Comparison of HIV characteristics across 3 datasets: the Korea HIV/AIDS Cohort Study prospective, retrospective, and national reporting system |
| title_fullStr | Comparison of HIV characteristics across 3 datasets: the Korea HIV/AIDS Cohort Study prospective, retrospective, and national reporting system |
| title_full_unstemmed | Comparison of HIV characteristics across 3 datasets: the Korea HIV/AIDS Cohort Study prospective, retrospective, and national reporting system |
| title_short | Comparison of HIV characteristics across 3 datasets: the Korea HIV/AIDS Cohort Study prospective, retrospective, and national reporting system |
| title_sort | comparison of hiv characteristics across 3 datasets the korea hiv aids cohort study prospective retrospective and national reporting system |
| topic | cohort studies selection bias research design hiv acquired immunodeficiency syndrome |
| url | http://www.e-epih.org/upload/pdf/epih-46-e2024055.pdf |
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