The role of bone marrow microenvironment in the progression of multiple myeloma from monoclonal gammopathy of undetermined significance
Multiple myeloma is a tumor of plasma cells, one of the most common malignant blood diseases. It is preceded by a stage called monoclonal gammopathy of undetermined significance, from which true multiple myeloma develops in only a small percentage of cases. It was assumed that this process is associ...
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| Language: | Russian |
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ABV-press
2021-09-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/484 |
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| author | A. S. Khudovekova Ya. A. Rudenko A. E. Dorosevich |
| author_facet | A. S. Khudovekova Ya. A. Rudenko A. E. Dorosevich |
| author_sort | A. S. Khudovekova |
| collection | DOAJ |
| description | Multiple myeloma is a tumor of plasma cells, one of the most common malignant blood diseases. It is preceded by a stage called monoclonal gammopathy of undetermined significance, from which true multiple myeloma develops in only a small percentage of cases. It was assumed that this process is associated with the accumulation of genetic mutations, but in recent years there is increasing evidence that the bone marrow microenvironment plays a key role in progression and that it can become a target for therapy that prevents the myeloma development. The review considers the role of mesenchymal stem cells, immune system cells, endotheliocytes, fibroblasts, adipocytes, osteoclasts and osteoblasts in multiple myeloma progression, as well as the impact of the sympathetic nervous system and microbiome composition. |
| format | Article |
| id | doaj-art-b02e25588b814605b672f7b030ca805d |
| institution | DOAJ |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2021-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-b02e25588b814605b672f7b030ca805d2025-08-20T03:21:27ZrusABV-pressОнкогематология1818-83462413-40232021-09-01163263210.17650/1818-8346-2021-16-3-26-32396The role of bone marrow microenvironment in the progression of multiple myeloma from monoclonal gammopathy of undetermined significanceA. S. Khudovekova0Ya. A. Rudenko1A. E. Dorosevich2Smolensk State Medical University, Ministry of Health of RussiaSmolensk State Medical University, Ministry of Health of Russia; Smolensk Regional Institute of PathologySmolensk State Medical University, Ministry of Health of Russia; Smolensk Regional Institute of PathologyMultiple myeloma is a tumor of plasma cells, one of the most common malignant blood diseases. It is preceded by a stage called monoclonal gammopathy of undetermined significance, from which true multiple myeloma develops in only a small percentage of cases. It was assumed that this process is associated with the accumulation of genetic mutations, but in recent years there is increasing evidence that the bone marrow microenvironment plays a key role in progression and that it can become a target for therapy that prevents the myeloma development. The review considers the role of mesenchymal stem cells, immune system cells, endotheliocytes, fibroblasts, adipocytes, osteoclasts and osteoblasts in multiple myeloma progression, as well as the impact of the sympathetic nervous system and microbiome composition.https://oncohematology.abvpress.ru/ongm/article/view/484multiple myelomamonoclonal gammopathy of undetermined significancebone marrow microenvironment |
| spellingShingle | A. S. Khudovekova Ya. A. Rudenko A. E. Dorosevich The role of bone marrow microenvironment in the progression of multiple myeloma from monoclonal gammopathy of undetermined significance Онкогематология multiple myeloma monoclonal gammopathy of undetermined significance bone marrow microenvironment |
| title | The role of bone marrow microenvironment in the progression of multiple myeloma from monoclonal gammopathy of undetermined significance |
| title_full | The role of bone marrow microenvironment in the progression of multiple myeloma from monoclonal gammopathy of undetermined significance |
| title_fullStr | The role of bone marrow microenvironment in the progression of multiple myeloma from monoclonal gammopathy of undetermined significance |
| title_full_unstemmed | The role of bone marrow microenvironment in the progression of multiple myeloma from monoclonal gammopathy of undetermined significance |
| title_short | The role of bone marrow microenvironment in the progression of multiple myeloma from monoclonal gammopathy of undetermined significance |
| title_sort | role of bone marrow microenvironment in the progression of multiple myeloma from monoclonal gammopathy of undetermined significance |
| topic | multiple myeloma monoclonal gammopathy of undetermined significance bone marrow microenvironment |
| url | https://oncohematology.abvpress.ru/ongm/article/view/484 |
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