Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma
Asthma represents a public health problem and traditionally is classified as an atopic disease, where the allergen can induce clinical airway inflammation, bronchial hyperresponsiveness, and reversible obstruction of airways. Studies have demonstrated the presence of T-helper 2 lymphocytes in the lu...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/538670 |
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| author | Francieli Vuolo Fabricia Petronilho Beatriz Sonai Cristiane Ritter Jaime E. C. Hallak Antonio Waldo Zuardi José A. Crippa Felipe Dal-Pizzol |
| author_facet | Francieli Vuolo Fabricia Petronilho Beatriz Sonai Cristiane Ritter Jaime E. C. Hallak Antonio Waldo Zuardi José A. Crippa Felipe Dal-Pizzol |
| author_sort | Francieli Vuolo |
| collection | DOAJ |
| description | Asthma represents a public health problem and traditionally is classified as an atopic disease, where the allergen can induce clinical airway inflammation, bronchial hyperresponsiveness, and reversible obstruction of airways. Studies have demonstrated the presence of T-helper 2 lymphocytes in the lung of patients with asthma. These cells are involved in cytokine production that regulates immunoglobulin synthesis. Recognizing that T cell interaction with antigens/allergens is key to the development of inflammatory diseases, the aim of this study is to evaluate the anti-inflammatory potential of cannabidiol (CBD) in this setting. Asthma was induced in 8-week-old Wistar rats by ovalbumin (OVA). In the last 2 days of OVA challenge animals received CBD (5 mg/kg, i.p.) and were killed 24 hours after. The levels of IL-4, IL-5, IL-13, IL-6, IL-10, and TNF-α were determinate in the serum. CBD treatment was able to decrease the serum levels of all analyzed cytokines except for IL-10 levels. CBD seems to be a potential new drug to modulate inflammatory response in asthma. |
| format | Article |
| id | doaj-art-b02caa32c9144f529fb7666b66445e33 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b02caa32c9144f529fb7666b66445e332025-08-20T03:39:15ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/538670538670Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of AsthmaFrancieli Vuolo0Fabricia Petronilho1Beatriz Sonai2Cristiane Ritter3Jaime E. C. Hallak4Antonio Waldo Zuardi5José A. Crippa6Felipe Dal-Pizzol7Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806000 Criciúma, SC, BrazilPrograma de Pós-Graduação em Ciências da Saúde, Universidade do Sul de Santa Catarina, 88704900 Tubarão, SC, BrazilLaboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806000 Criciúma, SC, BrazilLaboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806000 Criciúma, SC, BrazilDepartamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049900 Ribeirão Preto, SP, BrazilDepartamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049900 Ribeirão Preto, SP, BrazilDepartamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049900 Ribeirão Preto, SP, BrazilLaboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806000 Criciúma, SC, BrazilAsthma represents a public health problem and traditionally is classified as an atopic disease, where the allergen can induce clinical airway inflammation, bronchial hyperresponsiveness, and reversible obstruction of airways. Studies have demonstrated the presence of T-helper 2 lymphocytes in the lung of patients with asthma. These cells are involved in cytokine production that regulates immunoglobulin synthesis. Recognizing that T cell interaction with antigens/allergens is key to the development of inflammatory diseases, the aim of this study is to evaluate the anti-inflammatory potential of cannabidiol (CBD) in this setting. Asthma was induced in 8-week-old Wistar rats by ovalbumin (OVA). In the last 2 days of OVA challenge animals received CBD (5 mg/kg, i.p.) and were killed 24 hours after. The levels of IL-4, IL-5, IL-13, IL-6, IL-10, and TNF-α were determinate in the serum. CBD treatment was able to decrease the serum levels of all analyzed cytokines except for IL-10 levels. CBD seems to be a potential new drug to modulate inflammatory response in asthma.http://dx.doi.org/10.1155/2015/538670 |
| spellingShingle | Francieli Vuolo Fabricia Petronilho Beatriz Sonai Cristiane Ritter Jaime E. C. Hallak Antonio Waldo Zuardi José A. Crippa Felipe Dal-Pizzol Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma Mediators of Inflammation |
| title | Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma |
| title_full | Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma |
| title_fullStr | Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma |
| title_full_unstemmed | Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma |
| title_short | Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma |
| title_sort | evaluation of serum cytokines levels and the role of cannabidiol treatment in animal model of asthma |
| url | http://dx.doi.org/10.1155/2015/538670 |
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