Development and evaluation of a 99mTc-labeled olaparib analog for PARP imaging

Development and evaluation of a 99mTc-labeled olaparib analog for PARP imaging

Abstract Background Poly(ADP-ribose) polymerase (PARP) is an important therapeutic target in cancer treatment, and dynamic assessment of its expression level is essential for achieving precision therapy. Although 18F-labeled PARP-targeted radiotracers have demonstrated remarkable tumor-imaging capab...

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Bibliographic Details
Main Authors: Wei Xu, Junjie Yan, Xinlin Zhong, Donghui Pan, Xinyu Wang, Yuping Xu, Lizhen Wang, Chongyang Chen, Min Yang
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
99mTc
SPECT imaging
PARP
Olaparib
Cancer diagnosis
Online Access:https://doi.org/10.1186/s41181-025-00373-4
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