The single-cell immune profile throughout gestation and its potential value for identifying women at risk for spontaneous preterm birth
Precisely timed immune adaptations, observed in the maternal circulation, underpin the notion of an immune clock of human pregnancy that supports its successful progression and completion at delivery. This immune clock is divided into three immunological phases, with the first phase starting at the...
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Elsevier
2025-03-01
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| Series: | European Journal of Obstetrics & Gynecology and Reproductive Biology: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590161325000079 |
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| author | Dorien Feyaerts Maïgane Diop Jose Galaz Jakob F. Einhaus Petra C. Arck Anke Diemert Virginia D. Winn Mana Parast Cynthia Gyamfi-Bannerman Jelmer R. Prins Nardhy Gomez-Lopez Ina A. Stelzer |
| author_facet | Dorien Feyaerts Maïgane Diop Jose Galaz Jakob F. Einhaus Petra C. Arck Anke Diemert Virginia D. Winn Mana Parast Cynthia Gyamfi-Bannerman Jelmer R. Prins Nardhy Gomez-Lopez Ina A. Stelzer |
| author_sort | Dorien Feyaerts |
| collection | DOAJ |
| description | Precisely timed immune adaptations, observed in the maternal circulation, underpin the notion of an immune clock of human pregnancy that supports its successful progression and completion at delivery. This immune clock is divided into three immunological phases, with the first phase starting at the time of conception and implantation, shifting into the second phase that supports homeostasis and tolerance throughout pregnancy, and culminating in the last phase of labor and parturition. Disruptions of this immune clock are reported in pregnancy complications such as spontaneous preterm birth. However, our understanding of the immune clock preceding spontaneous preterm birth remains scattered. In this review, we describe the chronology of maternal immune cell adaptations during healthy pregnancies and highlight its disruption in spontaneous preterm birth. With a focus on single-cell cytometric, proteomic and transcriptomic approaches, we review recent studies of term and spontaneous preterm pregnancies and discuss the need for future prospective studies aimed at tracking pregnancies longitudinally on a multi-omic scale. Such studies will be critical in determining whether spontaneous preterm pregnancies progress at an accelerated pace or follow a preterm-intrinsic pattern when compared to those delivered at term. |
| format | Article |
| id | doaj-art-b022f2fb384b4440a5735e82fd198c29 |
| institution | DOAJ |
| issn | 2590-1613 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Obstetrics & Gynecology and Reproductive Biology: X |
| spelling | doaj-art-b022f2fb384b4440a5735e82fd198c292025-08-20T03:02:47ZengElsevierEuropean Journal of Obstetrics & Gynecology and Reproductive Biology: X2590-16132025-03-012510037110.1016/j.eurox.2025.100371The single-cell immune profile throughout gestation and its potential value for identifying women at risk for spontaneous preterm birthDorien Feyaerts0Maïgane Diop1Jose Galaz2Jakob F. Einhaus3Petra C. Arck4Anke Diemert5Virginia D. Winn6Mana Parast7Cynthia Gyamfi-Bannerman8Jelmer R. Prins9Nardhy Gomez-Lopez10Ina A. Stelzer11Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USADepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USADivision of Obstetrics and Gynecology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, ChileDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USADepartment of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Obstetrics and Gynecology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USADepartment of Pathology, University of California San Diego, La Jolla, CA, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USADepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, La Jolla, CA, USADepartment of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen, Groningen, the NetherlandsDepartments of Obstetrics and Gynecology & Pathology and Immunology, Washington University School of Medicine, St. Louis, USADepartment of Pathology, University of California San Diego, La Jolla, CA, USA; Corresponding author.Precisely timed immune adaptations, observed in the maternal circulation, underpin the notion of an immune clock of human pregnancy that supports its successful progression and completion at delivery. This immune clock is divided into three immunological phases, with the first phase starting at the time of conception and implantation, shifting into the second phase that supports homeostasis and tolerance throughout pregnancy, and culminating in the last phase of labor and parturition. Disruptions of this immune clock are reported in pregnancy complications such as spontaneous preterm birth. However, our understanding of the immune clock preceding spontaneous preterm birth remains scattered. In this review, we describe the chronology of maternal immune cell adaptations during healthy pregnancies and highlight its disruption in spontaneous preterm birth. With a focus on single-cell cytometric, proteomic and transcriptomic approaches, we review recent studies of term and spontaneous preterm pregnancies and discuss the need for future prospective studies aimed at tracking pregnancies longitudinally on a multi-omic scale. Such studies will be critical in determining whether spontaneous preterm pregnancies progress at an accelerated pace or follow a preterm-intrinsic pattern when compared to those delivered at term.http://www.sciencedirect.com/science/article/pii/S2590161325000079Spontaneous preterm labor and birthImmune responseMaternal immune adaptationImmune clock of pregnancySingle-cell proteome and transcriptome |
| spellingShingle | Dorien Feyaerts Maïgane Diop Jose Galaz Jakob F. Einhaus Petra C. Arck Anke Diemert Virginia D. Winn Mana Parast Cynthia Gyamfi-Bannerman Jelmer R. Prins Nardhy Gomez-Lopez Ina A. Stelzer The single-cell immune profile throughout gestation and its potential value for identifying women at risk for spontaneous preterm birth European Journal of Obstetrics & Gynecology and Reproductive Biology: X Spontaneous preterm labor and birth Immune response Maternal immune adaptation Immune clock of pregnancy Single-cell proteome and transcriptome |
| title | The single-cell immune profile throughout gestation and its potential value for identifying women at risk for spontaneous preterm birth |
| title_full | The single-cell immune profile throughout gestation and its potential value for identifying women at risk for spontaneous preterm birth |
| title_fullStr | The single-cell immune profile throughout gestation and its potential value for identifying women at risk for spontaneous preterm birth |
| title_full_unstemmed | The single-cell immune profile throughout gestation and its potential value for identifying women at risk for spontaneous preterm birth |
| title_short | The single-cell immune profile throughout gestation and its potential value for identifying women at risk for spontaneous preterm birth |
| title_sort | single cell immune profile throughout gestation and its potential value for identifying women at risk for spontaneous preterm birth |
| topic | Spontaneous preterm labor and birth Immune response Maternal immune adaptation Immune clock of pregnancy Single-cell proteome and transcriptome |
| url | http://www.sciencedirect.com/science/article/pii/S2590161325000079 |
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