Effects of Dietary <i>Clostridium butyricum</i> on Growth and Intestinal Mucosal Barrier Functions of Juvenile Channel Catfish (<i>Ictalurus punctatus</i>)

Effects of Dietary <i>Clostridium butyricum</i> on Growth and Intestinal Mucosal Barrier Functions of Juvenile Channel Catfish (<i>Ictalurus punctatus</i>)

An 8-week feeding trial was conducted to investigate the effects of dietary <i>Clostridium butyricum</i> on the growth and intestinal mucosal barrier functions of juvenile channel catfish (<i>Ictalurus punctatus</i>). The diets included the control group feed (CD group) and t...

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Bibliographic Details
Main Authors: Zihe Guo, Ye Qian, Xiao Peng, Chanxia Qin, Huige Ren, Jingyi Du, Chengrui Huang, Mingzhu Pan, Weihao Ou
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Microorganisms
Subjects:
<i>Ictalurus punctatus</i>
<i>Clostridium butyricum</i>
gut microbiota
intestinal metabolome
intestinal health
Online Access:https://www.mdpi.com/2076-2607/13/5/1061
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Summary:An 8-week feeding trial was conducted to investigate the effects of dietary <i>Clostridium butyricum</i> on the growth and intestinal mucosal barrier functions of juvenile channel catfish (<i>Ictalurus punctatus</i>). The diets included the control group feed (CD group) and the treatment group feed (containing 1 × 10<sup>8</sup> CFU/g <i>C. butyricum</i>; CB group). The CB group showed a rising trend in the growth performance. The CB group had significantly higher digestive and antioxidant enzyme activities, and significantly lower malondialdehyde and superoxide anion contents of the intestine. In terms of intestinal mechanical barrier, the CB group showed significantly higher gene expression of intestinal tight junction proteins. With regard to intestinal immune barrier, the CB group displayed significantly lower gene expression of pro-inflammatory factors. Regarding intestinal chemical barrier, the CB group had significantly higher gene expression of <i>mucin-4</i>, <i>β-galactoside-binding lectin</i>, <i>lysozyme-c</i>, and <i>NK-lysin type 1</i>. Dietary <i>C. butyricum</i> significantly increased the abundance of some beneficial bacteria and increased the levels of some beneficial metabolites in the intestine. Collectively, dietary <i>C. butyricum</i> could increase growth, enhance intestinal digestion and antioxidant capacity, strengthen intestinal mucosal barrier, and improve the intestinal metabolism of juvenile channel catfish.
ISSN:2076-2607

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