CLINICAL CASE OF USING TOCILIZUMAB FOR A FEMALE PATIENT WITH AN EARLY DEBUT OF SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS
The article describes a case of an early debut and difficult treatment of systemic juvenile idiopathic arthritis resistant to peroral glucocorticoids. The described clinical example demonstrates the successful use of tocilizumab, a monoclonal antibody drug, against interleukin-6 receptors. After the...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2014-10-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/159 |
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| author | О. L. Lomakina Ye. I. Alekseyeva S. I. Valieva Т. М. Bzarova R. V. Denisova Т. V. Sleptsova |
| author_facet | О. L. Lomakina Ye. I. Alekseyeva S. I. Valieva Т. М. Bzarova R. V. Denisova Т. V. Sleptsova |
| author_sort | О. L. Lomakina |
| collection | DOAJ |
| description | The article describes a case of an early debut and difficult treatment of systemic juvenile idiopathic arthritis resistant to peroral glucocorticoids. The described clinical example demonstrates the successful use of tocilizumab, a monoclonal antibody drug, against interleukin-6 receptors. After the 1st drug infusion the systemic manifestations of the disease were alleviated, by the 6th week of the tocilizumab treatment inflammatory changes in the joints were reduced, and by the 16th week the inactive stage of the disease was registered, which made it possible to stop the administration of glucocorticoids per os. Duration of remission of articular syndrome and extra-articular manifestations was 10 months. |
| format | Article |
| id | doaj-art-b017d2a887d04aeb9b46599bd3aa3c36 |
| institution | Kabale University |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2014-10-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-b017d2a887d04aeb9b46599bd3aa3c362025-08-20T03:35:16Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352014-10-0113510010310.15690/vsp.v13i5.1159159CLINICAL CASE OF USING TOCILIZUMAB FOR A FEMALE PATIENT WITH AN EARLY DEBUT OF SYSTEMIC JUVENILE IDIOPATHIC ARTHRITISО. L. Lomakina0Ye. I. Alekseyeva1S. I. Valieva2Т. М. Bzarova3R. V. Denisova4Т. V. Sleptsova5Scientific Centre of Children Health, MoscowScientific Centre of Children Health, Moscow; I.M. Sechenov First Moscow State Medical UniversityScientific Centre of Children Health, MoscowScientific Centre of Children Health, MoscowScientific Centre of Children Health, MoscowScientific Centre of Children Health, MoscowThe article describes a case of an early debut and difficult treatment of systemic juvenile idiopathic arthritis resistant to peroral glucocorticoids. The described clinical example demonstrates the successful use of tocilizumab, a monoclonal antibody drug, against interleukin-6 receptors. After the 1st drug infusion the systemic manifestations of the disease were alleviated, by the 6th week of the tocilizumab treatment inflammatory changes in the joints were reduced, and by the 16th week the inactive stage of the disease was registered, which made it possible to stop the administration of glucocorticoids per os. Duration of remission of articular syndrome and extra-articular manifestations was 10 months.https://vsp.spr-journal.ru/jour/article/view/159childrensystemic juvenile idiopathic arthritistocilizumab |
| spellingShingle | О. L. Lomakina Ye. I. Alekseyeva S. I. Valieva Т. М. Bzarova R. V. Denisova Т. V. Sleptsova CLINICAL CASE OF USING TOCILIZUMAB FOR A FEMALE PATIENT WITH AN EARLY DEBUT OF SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS Вопросы современной педиатрии children systemic juvenile idiopathic arthritis tocilizumab |
| title | CLINICAL CASE OF USING TOCILIZUMAB FOR A FEMALE PATIENT WITH AN EARLY DEBUT OF SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS |
| title_full | CLINICAL CASE OF USING TOCILIZUMAB FOR A FEMALE PATIENT WITH AN EARLY DEBUT OF SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS |
| title_fullStr | CLINICAL CASE OF USING TOCILIZUMAB FOR A FEMALE PATIENT WITH AN EARLY DEBUT OF SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS |
| title_full_unstemmed | CLINICAL CASE OF USING TOCILIZUMAB FOR A FEMALE PATIENT WITH AN EARLY DEBUT OF SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS |
| title_short | CLINICAL CASE OF USING TOCILIZUMAB FOR A FEMALE PATIENT WITH AN EARLY DEBUT OF SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS |
| title_sort | clinical case of using tocilizumab for a female patient with an early debut of systemic juvenile idiopathic arthritis |
| topic | children systemic juvenile idiopathic arthritis tocilizumab |
| url | https://vsp.spr-journal.ru/jour/article/view/159 |
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