The Prognostic Significance of Tumor Budding and Cell Nest Size in Laryngeal Squamous Cell Carcinoma
ABSTRACT Background Laryngeal squamous cell carcinoma (LSCC) is a commonly occurring malignancy in the head and neck region. However, due to the heterogeneity of primary tumor sites, tumor behavior, and molecular mechanisms, there is currently no consensus on the accuracy of clinicopathological prog...
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2024-11-01
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| Online Access: | https://doi.org/10.1002/cnr2.70052 |
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| author | Kiana Anousha Mohammad Moin Shekari Elham Mirzaian Tahere Yousefi Amin Beheshti Maryam Lotfi |
| author_facet | Kiana Anousha Mohammad Moin Shekari Elham Mirzaian Tahere Yousefi Amin Beheshti Maryam Lotfi |
| author_sort | Kiana Anousha |
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| description | ABSTRACT Background Laryngeal squamous cell carcinoma (LSCC) is a commonly occurring malignancy in the head and neck region. However, due to the heterogeneity of primary tumor sites, tumor behavior, and molecular mechanisms, there is currently no consensus on the accuracy of clinicopathological prognostic factors for individual cases. Tumor histopathologic behavior remains a crucial factor in predicting aggressiveness. Recent studies have shown that peritumoral tumor budding (TB) combined with cell nest size (CNS) is a reliable marker for predicting lymph node metastasis, advanced cancer prognosis, and therapeutic response in SCCs of different origins. Aims This study aims to investigate the relationship between TB and CNS in the context of nodal metastasis and overall prognosis in patients diagnosed with LSCC. Our objective is to establish the significance of TB and CNS status as a cost‐effective, easily assessed, and highly reliable prognostic factor among this patient population. Methods and results In this retrospective cross‐sectional study, we analyzed 128 LSCC cases that underwent total laryngectomy at Amir Alam Hospital. We evaluated TB and CNS based on the Boxberg et al. study. Our study demonstrated a significant correlation between TB, and nodal involvement (p = 0.015), vascular invasion (p = 0.035), and mortality rate (p = 0.001), as well as a significant statistical correlation between high TB and extra‐laryngeal extension (p = 0.006), clinical stage (p = 0.011), and mortality rate (p = 0.001). Moreover, small nest size was also associated with the clinical stage (p = 0.047), extra‐laryngeal extension (p = 0.015), and mortality rate (p < 0.001). Based on our results, TB, CNS, and clinical stage are independent prognostic factors for mortality rate and are correlated with disease‐specific survival. Conclusion Given the effect of TB and CNS on the overall prognosis and survival of patients with LSCC, evaluating these two factors on routine H&E microscopic examination of LSCC specimens is recommended to facilitate individualized risk assessment and treatment planning. |
| format | Article |
| id | doaj-art-b015c69ed9fd4d8fbd07f9c672a67757 |
| institution | OA Journals |
| issn | 2573-8348 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj-art-b015c69ed9fd4d8fbd07f9c672a677572025-08-20T02:05:28ZengWileyCancer Reports2573-83482024-11-01711n/an/a10.1002/cnr2.70052The Prognostic Significance of Tumor Budding and Cell Nest Size in Laryngeal Squamous Cell CarcinomaKiana Anousha0Mohammad Moin Shekari1Elham Mirzaian2Tahere Yousefi3Amin Beheshti4Maryam Lotfi5Pathology Department Tehran University of Medical Sciences Tehran IranPathology Department Tehran University of Medical Sciences Tehran IranPathology Department Shariati Hospital, Tehran University of Medical Sciences Tehran IranPathology Department Amir Alam Hospital, Tehran University of Medical Sciences Tehran IranOtorhinolaryngology Research Center Amir Alam Hospital, Tehran University of Medical Sciences Tehran IranPathology Department Amir Alam Hospital, Tehran University of Medical Sciences Tehran IranABSTRACT Background Laryngeal squamous cell carcinoma (LSCC) is a commonly occurring malignancy in the head and neck region. However, due to the heterogeneity of primary tumor sites, tumor behavior, and molecular mechanisms, there is currently no consensus on the accuracy of clinicopathological prognostic factors for individual cases. Tumor histopathologic behavior remains a crucial factor in predicting aggressiveness. Recent studies have shown that peritumoral tumor budding (TB) combined with cell nest size (CNS) is a reliable marker for predicting lymph node metastasis, advanced cancer prognosis, and therapeutic response in SCCs of different origins. Aims This study aims to investigate the relationship between TB and CNS in the context of nodal metastasis and overall prognosis in patients diagnosed with LSCC. Our objective is to establish the significance of TB and CNS status as a cost‐effective, easily assessed, and highly reliable prognostic factor among this patient population. Methods and results In this retrospective cross‐sectional study, we analyzed 128 LSCC cases that underwent total laryngectomy at Amir Alam Hospital. We evaluated TB and CNS based on the Boxberg et al. study. Our study demonstrated a significant correlation between TB, and nodal involvement (p = 0.015), vascular invasion (p = 0.035), and mortality rate (p = 0.001), as well as a significant statistical correlation between high TB and extra‐laryngeal extension (p = 0.006), clinical stage (p = 0.011), and mortality rate (p = 0.001). Moreover, small nest size was also associated with the clinical stage (p = 0.047), extra‐laryngeal extension (p = 0.015), and mortality rate (p < 0.001). Based on our results, TB, CNS, and clinical stage are independent prognostic factors for mortality rate and are correlated with disease‐specific survival. Conclusion Given the effect of TB and CNS on the overall prognosis and survival of patients with LSCC, evaluating these two factors on routine H&E microscopic examination of LSCC specimens is recommended to facilitate individualized risk assessment and treatment planning.https://doi.org/10.1002/cnr2.70052cell nest sizelarynxsquamous cell carcinomatumor budding |
| spellingShingle | Kiana Anousha Mohammad Moin Shekari Elham Mirzaian Tahere Yousefi Amin Beheshti Maryam Lotfi The Prognostic Significance of Tumor Budding and Cell Nest Size in Laryngeal Squamous Cell Carcinoma Cancer Reports cell nest size larynx squamous cell carcinoma tumor budding |
| title | The Prognostic Significance of Tumor Budding and Cell Nest Size in Laryngeal Squamous Cell Carcinoma |
| title_full | The Prognostic Significance of Tumor Budding and Cell Nest Size in Laryngeal Squamous Cell Carcinoma |
| title_fullStr | The Prognostic Significance of Tumor Budding and Cell Nest Size in Laryngeal Squamous Cell Carcinoma |
| title_full_unstemmed | The Prognostic Significance of Tumor Budding and Cell Nest Size in Laryngeal Squamous Cell Carcinoma |
| title_short | The Prognostic Significance of Tumor Budding and Cell Nest Size in Laryngeal Squamous Cell Carcinoma |
| title_sort | prognostic significance of tumor budding and cell nest size in laryngeal squamous cell carcinoma |
| topic | cell nest size larynx squamous cell carcinoma tumor budding |
| url | https://doi.org/10.1002/cnr2.70052 |
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