Circadian gene BMAL1 ameliorates renal ischaemia-reperfusion injury in diabetic mice by enhancing mitophagy via the HIF-1/BNIP3 pathway

Circadian gene BMAL1 ameliorates renal ischaemia-reperfusion injury in diabetic mice by enhancing mitophagy via the HIF-1/BNIP3 pathway

Abstract Diabetic kidneys are particularly vulnerable to ischemia/reperfusion injury (I/RI). Although previous research has suggested that the circadian gene brain and muscle ARNT-like 1 (BMAL1) plays a role in regulating renal function, the exact functions and mechanisms of BMAL1 in diabetic renal...

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Bibliographic Details
Main Authors: Xinqi Deng, Yan Leng, Yonghong Xiong, Wenyuan Li, Wu Chen, Yuhang Yang, Bihan Wang, Siyuan Gong, Yunhao Wang, Baichuan Yang, Wei Li
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
BMAL1
Diabetes
HIF-1α
Ischemia/reperfusion injury
Mitophagy
Online Access:https://doi.org/10.1038/s41598-025-03515-5
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