Assessment of ventilatory function in patients with spinocerebellar ataxia type 2
Abstract Subclinical ventilatory dysfunction is observed in individuals with spinocerebellar ataxias (SCA). No studies have correlated ventilatory dysfunction to clinical and functional decline in SCA2. Objective: To evaluate the relationship between the values of peak expiratory flow (PEF), maxim...
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Thieme Revinter Publicações
2020-02-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000200096&tlng=en |
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| author | Neliana Maria de MELLO Marise Bueno ZONTA Hélio Afonso Ghizoni TEIVE Alex Tiburtino MEIRA Francisco Diego Negrão LOPES NETO Janaína Turcato da Silva Nonato da SILVA Carlos Henrique Ferreira CAMARGO Bianca Simone ZEIGELBOIM |
| author_facet | Neliana Maria de MELLO Marise Bueno ZONTA Hélio Afonso Ghizoni TEIVE Alex Tiburtino MEIRA Francisco Diego Negrão LOPES NETO Janaína Turcato da Silva Nonato da SILVA Carlos Henrique Ferreira CAMARGO Bianca Simone ZEIGELBOIM |
| author_sort | Neliana Maria de MELLO |
| collection | DOAJ |
| description | Abstract Subclinical ventilatory dysfunction is observed in individuals with spinocerebellar ataxias (SCA). No studies have correlated ventilatory dysfunction to clinical and functional decline in SCA2. Objective: To evaluate the relationship between the values of peak expiratory flow (PEF), maximum inspiratory pressure (MIP), and presence of respiratory complaints with age, disease duration, age at onset of symptoms, balance scores, independence in basic (ADL) and instrumental (IADL) Activities of Daily Living (ADLs), and severity of ataxia (SARA) in individuals with SCA2. Methods: Cross-sectional study evaluating age, disease duration, age at onset of symptoms, scores in the Berg Balance Scale and in the SARA, Functional Independence Measure and Lawton’s scale, values of PEF and MIP, and the presence of respiratory complaints. Results: The study included 36 individuals with SCA2, with a mean age of 42.5±2.4 years, disease duration of 7.6±8.2 years, age 33.7±11.5 years at onset of symptoms, and 9.9±10.3 points in the SARA scale. The lowest PEF values correlated with the longer disease duration (p=0.021). The lowest values of PEF and MIP correlated with greater balance impairment (p=0.019 and p=0.045, respectively), increased degree of dependence in the ADL (p=0.006 and p=0.050, respectively) and IADL (p=0.003 and p=0.001, respectively) scales, and highest severity of ataxia (p=0.00 and p=0.017, respectively). Respiratory complaints were observed in 12 (33.3%) individuals and were not related to age, disease duration, age at onset of symptoms, balance, independence, ataxia severity, or PEF and MIP values. Conclusion: Ventilatory dysfunction, even when asymptomatic, is related to balance impairment, independence, and ataxia severity in individuals with SCA2. |
| format | Article |
| id | doaj-art-b012d653eada4a479b91ed1d3376128f |
| institution | Kabale University |
| issn | 1678-4227 |
| language | English |
| publishDate | 2020-02-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-b012d653eada4a479b91ed1d3376128f2025-08-20T03:39:15ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272020-02-017829610210.1590/0004-282x20190156Assessment of ventilatory function in patients with spinocerebellar ataxia type 2Neliana Maria de MELLOhttps://orcid.org/0000-0001-7776-4234Marise Bueno ZONTAhttps://orcid.org/0000-0003-1652-7723Hélio Afonso Ghizoni TEIVEhttps://orcid.org/0000-0003-2305-1073Alex Tiburtino MEIRAhttps://orcid.org/0000-0002-6685-7491Francisco Diego Negrão LOPES NETOhttps://orcid.org/0000-0003-2094-5928Janaína Turcato da Silva Nonato da SILVAhttps://orcid.org/0000-0002-7258-5146Carlos Henrique Ferreira CAMARGOhttps://orcid.org/0000-0002-3533-0347Bianca Simone ZEIGELBOIMhttps://orcid.org/0000-0003-4871-2683Abstract Subclinical ventilatory dysfunction is observed in individuals with spinocerebellar ataxias (SCA). No studies have correlated ventilatory dysfunction to clinical and functional decline in SCA2. Objective: To evaluate the relationship between the values of peak expiratory flow (PEF), maximum inspiratory pressure (MIP), and presence of respiratory complaints with age, disease duration, age at onset of symptoms, balance scores, independence in basic (ADL) and instrumental (IADL) Activities of Daily Living (ADLs), and severity of ataxia (SARA) in individuals with SCA2. Methods: Cross-sectional study evaluating age, disease duration, age at onset of symptoms, scores in the Berg Balance Scale and in the SARA, Functional Independence Measure and Lawton’s scale, values of PEF and MIP, and the presence of respiratory complaints. Results: The study included 36 individuals with SCA2, with a mean age of 42.5±2.4 years, disease duration of 7.6±8.2 years, age 33.7±11.5 years at onset of symptoms, and 9.9±10.3 points in the SARA scale. The lowest PEF values correlated with the longer disease duration (p=0.021). The lowest values of PEF and MIP correlated with greater balance impairment (p=0.019 and p=0.045, respectively), increased degree of dependence in the ADL (p=0.006 and p=0.050, respectively) and IADL (p=0.003 and p=0.001, respectively) scales, and highest severity of ataxia (p=0.00 and p=0.017, respectively). Respiratory complaints were observed in 12 (33.3%) individuals and were not related to age, disease duration, age at onset of symptoms, balance, independence, ataxia severity, or PEF and MIP values. Conclusion: Ventilatory dysfunction, even when asymptomatic, is related to balance impairment, independence, and ataxia severity in individuals with SCA2.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000200096&tlng=enspinocerebellar ataxiapeak expiratory flow ratemaximum inspiratory pressurepostural balancefunctional independencedisease severity index |
| spellingShingle | Neliana Maria de MELLO Marise Bueno ZONTA Hélio Afonso Ghizoni TEIVE Alex Tiburtino MEIRA Francisco Diego Negrão LOPES NETO Janaína Turcato da Silva Nonato da SILVA Carlos Henrique Ferreira CAMARGO Bianca Simone ZEIGELBOIM Assessment of ventilatory function in patients with spinocerebellar ataxia type 2 Arquivos de Neuro-Psiquiatria spinocerebellar ataxia peak expiratory flow rate maximum inspiratory pressure postural balance functional independence disease severity index |
| title | Assessment of ventilatory function in patients with spinocerebellar ataxia type 2 |
| title_full | Assessment of ventilatory function in patients with spinocerebellar ataxia type 2 |
| title_fullStr | Assessment of ventilatory function in patients with spinocerebellar ataxia type 2 |
| title_full_unstemmed | Assessment of ventilatory function in patients with spinocerebellar ataxia type 2 |
| title_short | Assessment of ventilatory function in patients with spinocerebellar ataxia type 2 |
| title_sort | assessment of ventilatory function in patients with spinocerebellar ataxia type 2 |
| topic | spinocerebellar ataxia peak expiratory flow rate maximum inspiratory pressure postural balance functional independence disease severity index |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000200096&tlng=en |
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