Progress in research on osteoporosis secondary to SARS‐CoV‐2 infection
Abstract The World Health Organization has declared that COVID‐19 no longer constitutes a “public health emergency of international concern,” yet the long‐term impact of SARS‐CoV‐2 infection on bone health continues to pose new challenges for global public health. In recent years, numerous animal mo...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-05-01
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| Series: | Animal Models and Experimental Medicine |
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| Online Access: | https://doi.org/10.1002/ame2.12573 |
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| author | Jinlong Wang Yibai Xiong Zhiqi Song Yanhong Li Ling Zhang Chuan Qin |
| author_facet | Jinlong Wang Yibai Xiong Zhiqi Song Yanhong Li Ling Zhang Chuan Qin |
| author_sort | Jinlong Wang |
| collection | DOAJ |
| description | Abstract The World Health Organization has declared that COVID‐19 no longer constitutes a “public health emergency of international concern,” yet the long‐term impact of SARS‐CoV‐2 infection on bone health continues to pose new challenges for global public health. In recent years, numerous animal model and clinical studies have revealed that severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection can lead to secondary osteoporosis. The mechanisms involved are related to the virus's direct effects on bone tissue, dysregulation of the body's inflammatory response, hypoxia, noncoding RNA imbalance, and metabolic abnormalities. Although these studies have unveiled the connection between SARS‐CoV‐2 infection and osteoporosis, current research is not comprehensive and in depth. Future studies are needed to evaluate the long‐term effects of SARS‐CoV‐2 on bone density and metabolism, elucidate the specific mechanisms of pathogenesis, and explore potential interventions. This review aims to collate existing research literature on SARS‐CoV‐2 infection‐induced secondary osteoporosis, summarize the underlying mechanisms, and provide direction for future research. |
| format | Article |
| id | doaj-art-b0036b18b97f427badd72eff47a5cd5a |
| institution | OA Journals |
| issn | 2576-2095 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Animal Models and Experimental Medicine |
| spelling | doaj-art-b0036b18b97f427badd72eff47a5cd5a2025-08-20T01:56:57ZengWileyAnimal Models and Experimental Medicine2576-20952025-05-018582984110.1002/ame2.12573Progress in research on osteoporosis secondary to SARS‐CoV‐2 infectionJinlong Wang0Yibai Xiong1Zhiqi Song2Yanhong Li3Ling Zhang4Chuan Qin5Institute of Laboratory Animal Sciences, CAMS and Comparative Medicine Center, PUMC Beijing ChinaInstitute of Laboratory Animal Sciences, CAMS and Comparative Medicine Center, PUMC Beijing ChinaInstitute of Laboratory Animal Sciences, CAMS and Comparative Medicine Center, PUMC Beijing ChinaInstitute of Laboratory Animal Sciences, CAMS and Comparative Medicine Center, PUMC Beijing ChinaInstitute of Laboratory Animal Sciences, CAMS and Comparative Medicine Center, PUMC Beijing ChinaInstitute of Laboratory Animal Sciences, CAMS and Comparative Medicine Center, PUMC Beijing ChinaAbstract The World Health Organization has declared that COVID‐19 no longer constitutes a “public health emergency of international concern,” yet the long‐term impact of SARS‐CoV‐2 infection on bone health continues to pose new challenges for global public health. In recent years, numerous animal model and clinical studies have revealed that severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection can lead to secondary osteoporosis. The mechanisms involved are related to the virus's direct effects on bone tissue, dysregulation of the body's inflammatory response, hypoxia, noncoding RNA imbalance, and metabolic abnormalities. Although these studies have unveiled the connection between SARS‐CoV‐2 infection and osteoporosis, current research is not comprehensive and in depth. Future studies are needed to evaluate the long‐term effects of SARS‐CoV‐2 on bone density and metabolism, elucidate the specific mechanisms of pathogenesis, and explore potential interventions. This review aims to collate existing research literature on SARS‐CoV‐2 infection‐induced secondary osteoporosis, summarize the underlying mechanisms, and provide direction for future research.https://doi.org/10.1002/ame2.12573bone metabolismCOVID‐19long COVIDosteoporosisSARS‐CoV‐2 |
| spellingShingle | Jinlong Wang Yibai Xiong Zhiqi Song Yanhong Li Ling Zhang Chuan Qin Progress in research on osteoporosis secondary to SARS‐CoV‐2 infection Animal Models and Experimental Medicine bone metabolism COVID‐19 long COVID osteoporosis SARS‐CoV‐2 |
| title | Progress in research on osteoporosis secondary to SARS‐CoV‐2 infection |
| title_full | Progress in research on osteoporosis secondary to SARS‐CoV‐2 infection |
| title_fullStr | Progress in research on osteoporosis secondary to SARS‐CoV‐2 infection |
| title_full_unstemmed | Progress in research on osteoporosis secondary to SARS‐CoV‐2 infection |
| title_short | Progress in research on osteoporosis secondary to SARS‐CoV‐2 infection |
| title_sort | progress in research on osteoporosis secondary to sars cov 2 infection |
| topic | bone metabolism COVID‐19 long COVID osteoporosis SARS‐CoV‐2 |
| url | https://doi.org/10.1002/ame2.12573 |
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