Cardioprotective effects of compound ALM-802 on subendocardial ischemia models
The investigation purpose. N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine (ALM-802 compounds) cardioprotective effect has been studied in rat models of subendocardial ischemia caused by isoproterenol and dobutamine. Material and methods. Acute subendocardia...
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2021-09-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/268 |
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| author | I. B. Tsorin V. V. Barchukov M. B. Vititnova A. M. Likhosherstov G. V. Mokrov S. A. Kryzhanovskii |
| author_facet | I. B. Tsorin V. V. Barchukov M. B. Vititnova A. M. Likhosherstov G. V. Mokrov S. A. Kryzhanovskii |
| author_sort | I. B. Tsorin |
| collection | DOAJ |
| description | The investigation purpose. N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine (ALM-802 compounds) cardioprotective effect has been studied in rat models of subendocardial ischemia caused by isoproterenol and dobutamine. Material and methods. Acute subendocardial myocardial ischemia in anesthetized rats (urethane 1300 mg/kg, i.p.) was caused by infusion of isoproterenol (20 µg/kg/min i.v.) or dobutamine (80 µg/kg/min i.v.). Results. It was shown that in anesthetized rats, isoproterenol and dobutamine caused almost the same ST-segment depression in the II standard ECG lead. The compound ALM-802 (2 mg/kg i.v.), administered 2 minutes before the infusion start of isoproterenol or dobutamine, equally prevented the occurrence of ischemic changes on the ECG. Conclusion. The non-selective beta-adrenomimetic isoproterenol and the selective β1-adrenomimetic dobutamine cause subendocardial ischemia of the same intensity in anesthetized rats. The compound ALM-802 has a pronounced anti-ischemic effect on both models. |
| format | Article |
| id | doaj-art-affe1d8e2cb2471e92e89234a9ed47c6 |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2021-09-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-affe1d8e2cb2471e92e89234a9ed47c62025-08-20T03:57:48ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302021-09-0101182210.37489/2587-7836-2021-1-18-22263Cardioprotective effects of compound ALM-802 on subendocardial ischemia modelsI. B. Tsorin0V. V. Barchukov1M. B. Vititnova2A. M. Likhosherstov3G. V. Mokrov4S. A. Kryzhanovskii5FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”The investigation purpose. N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine (ALM-802 compounds) cardioprotective effect has been studied in rat models of subendocardial ischemia caused by isoproterenol and dobutamine. Material and methods. Acute subendocardial myocardial ischemia in anesthetized rats (urethane 1300 mg/kg, i.p.) was caused by infusion of isoproterenol (20 µg/kg/min i.v.) or dobutamine (80 µg/kg/min i.v.). Results. It was shown that in anesthetized rats, isoproterenol and dobutamine caused almost the same ST-segment depression in the II standard ECG lead. The compound ALM-802 (2 mg/kg i.v.), administered 2 minutes before the infusion start of isoproterenol or dobutamine, equally prevented the occurrence of ischemic changes on the ECG. Conclusion. The non-selective beta-adrenomimetic isoproterenol and the selective β1-adrenomimetic dobutamine cause subendocardial ischemia of the same intensity in anesthetized rats. The compound ALM-802 has a pronounced anti-ischemic effect on both models.https://www.pharmacokinetica.ru/jour/article/view/268subendocardial ischemiaisoproterenoldobutaminepfox inhibitorscompound alm-802 |
| spellingShingle | I. B. Tsorin V. V. Barchukov M. B. Vititnova A. M. Likhosherstov G. V. Mokrov S. A. Kryzhanovskii Cardioprotective effects of compound ALM-802 on subendocardial ischemia models Фармакокинетика и Фармакодинамика subendocardial ischemia isoproterenol dobutamine pfox inhibitors compound alm-802 |
| title | Cardioprotective effects of compound ALM-802 on subendocardial ischemia models |
| title_full | Cardioprotective effects of compound ALM-802 on subendocardial ischemia models |
| title_fullStr | Cardioprotective effects of compound ALM-802 on subendocardial ischemia models |
| title_full_unstemmed | Cardioprotective effects of compound ALM-802 on subendocardial ischemia models |
| title_short | Cardioprotective effects of compound ALM-802 on subendocardial ischemia models |
| title_sort | cardioprotective effects of compound alm 802 on subendocardial ischemia models |
| topic | subendocardial ischemia isoproterenol dobutamine pfox inhibitors compound alm-802 |
| url | https://www.pharmacokinetica.ru/jour/article/view/268 |
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