Optimized quercetin-loaded glycerohyalurosome hydrogel: an innovative nanoplatform for enhanced wound healing
Abstract Background Lipidic nanovesicular systems have attracted researchers’ interest for more effective cutaneous delivery and topical pharmacological efficacy. Quercetin (QUT), a polyphenolic flavonoid known for its antioxidant and anti-inflammatory activity, suffers from poor solubility and bioa...
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SpringerOpen
2025-05-01
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| Series: | Future Journal of Pharmaceutical Sciences |
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| Online Access: | https://doi.org/10.1186/s43094-025-00808-4 |
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| author | Walaa Abualsunun Amerh Aiad Alahmadi Bayan A. Eshmawi Osama A. A. Ahmed Alaa Sirwi Mahmoud A. Elfaky Sarah O. Alreeshi Ibtisam A. Alzahrani Ibtihal A. Almutairi Rumaysaa M. Gurunfula Omaima N. Elgazayerly Shaimaa M. Badr-Eldin |
| author_facet | Walaa Abualsunun Amerh Aiad Alahmadi Bayan A. Eshmawi Osama A. A. Ahmed Alaa Sirwi Mahmoud A. Elfaky Sarah O. Alreeshi Ibtisam A. Alzahrani Ibtihal A. Almutairi Rumaysaa M. Gurunfula Omaima N. Elgazayerly Shaimaa M. Badr-Eldin |
| author_sort | Walaa Abualsunun |
| collection | DOAJ |
| description | Abstract Background Lipidic nanovesicular systems have attracted researchers’ interest for more effective cutaneous delivery and topical pharmacological efficacy. Quercetin (QUT), a polyphenolic flavonoid known for its antioxidant and anti-inflammatory activity, suffers from poor solubility and bioavailability. The aim of this research was to develop an optimized hydrogel formulation comprising QUT-loaded hyaluronic acid (HYA)-modified glycerosomes (glycerohyalurosomes, GHEs) for effective wound management. A combination of glycerol (GLY) and HYA is being used to provide flexibility to the vesicles for better delivery through the skin; these compounds have been reported to provide benefits for wound healing. Results D-optimal design suggested fifteen formulations of QUT-GHEs which were prepared using a modified thin-film hydration method. Results showed that particle sizes ranged from 162.33 to 478.49 nm and zeta potential from −57.8 to −18.8 mV. Transmission electron microscopy confirmed successful loading of the drug into the vesicles. QUT-GHEs were integrated into hydrogel (QUT-GHE-GEL) using 1.5% hydroxypropyl methylcellulose. The pH of the QUT-GHE-GEL was recorded as 5.9 ± 0.03, which is acceptable in wound healing. In vivo studies performed on Wistar rats showed that QUT-GHE-GEL accelerated the wound-healing process compared to the untreated control and marketed product (MP)-treated groups, where a significantly higher wound contraction was observed. Histopathological examination of wound tissues revealed that QUT-GHE-GEL-treated and MP-treated groups exhibited newly sprouted capillaries and enhanced fibroblast development. Conclusions Thus, the suggested QUT-GHE-GEL formulation shows promise for effective wound-healing management. QUT-GHE-GEL enhances wound contraction and fosters tissue regeneration while modulating inflammation. The results indicate that QUT-GHE-GEL proves a prospective therapeutic option for wound care applications. |
| format | Article |
| id | doaj-art-aff8395a5e6a4d4d90c2fe1b492b8435 |
| institution | OA Journals |
| issn | 2314-7253 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SpringerOpen |
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| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj-art-aff8395a5e6a4d4d90c2fe1b492b84352025-08-20T02:32:03ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72532025-05-0111111410.1186/s43094-025-00808-4Optimized quercetin-loaded glycerohyalurosome hydrogel: an innovative nanoplatform for enhanced wound healingWalaa Abualsunun0Amerh Aiad Alahmadi1Bayan A. Eshmawi2Osama A. A. Ahmed3Alaa Sirwi4Mahmoud A. Elfaky5Sarah O. Alreeshi6Ibtisam A. Alzahrani7Ibtihal A. Almutairi8Rumaysaa M. Gurunfula9Omaima N. Elgazayerly10Shaimaa M. Badr-Eldin11Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz UniversityDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz UniversityDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz UniversityDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz UniversityDepartment of Natural Products, Faculty of Pharmacy, King Abdulaziz UniversityDepartment of Natural Products, Faculty of Pharmacy, King Abdulaziz UniversityDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz UniversityDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz UniversityDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz UniversityDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz UniversityDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo UniversityDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz UniversityAbstract Background Lipidic nanovesicular systems have attracted researchers’ interest for more effective cutaneous delivery and topical pharmacological efficacy. Quercetin (QUT), a polyphenolic flavonoid known for its antioxidant and anti-inflammatory activity, suffers from poor solubility and bioavailability. The aim of this research was to develop an optimized hydrogel formulation comprising QUT-loaded hyaluronic acid (HYA)-modified glycerosomes (glycerohyalurosomes, GHEs) for effective wound management. A combination of glycerol (GLY) and HYA is being used to provide flexibility to the vesicles for better delivery through the skin; these compounds have been reported to provide benefits for wound healing. Results D-optimal design suggested fifteen formulations of QUT-GHEs which were prepared using a modified thin-film hydration method. Results showed that particle sizes ranged from 162.33 to 478.49 nm and zeta potential from −57.8 to −18.8 mV. Transmission electron microscopy confirmed successful loading of the drug into the vesicles. QUT-GHEs were integrated into hydrogel (QUT-GHE-GEL) using 1.5% hydroxypropyl methylcellulose. The pH of the QUT-GHE-GEL was recorded as 5.9 ± 0.03, which is acceptable in wound healing. In vivo studies performed on Wistar rats showed that QUT-GHE-GEL accelerated the wound-healing process compared to the untreated control and marketed product (MP)-treated groups, where a significantly higher wound contraction was observed. Histopathological examination of wound tissues revealed that QUT-GHE-GEL-treated and MP-treated groups exhibited newly sprouted capillaries and enhanced fibroblast development. Conclusions Thus, the suggested QUT-GHE-GEL formulation shows promise for effective wound-healing management. QUT-GHE-GEL enhances wound contraction and fosters tissue regeneration while modulating inflammation. The results indicate that QUT-GHE-GEL proves a prospective therapeutic option for wound care applications.https://doi.org/10.1186/s43094-025-00808-4QuercetinGlycerohyalurosomesHydrogelWound healingD-optimal designDrug delivery |
| spellingShingle | Walaa Abualsunun Amerh Aiad Alahmadi Bayan A. Eshmawi Osama A. A. Ahmed Alaa Sirwi Mahmoud A. Elfaky Sarah O. Alreeshi Ibtisam A. Alzahrani Ibtihal A. Almutairi Rumaysaa M. Gurunfula Omaima N. Elgazayerly Shaimaa M. Badr-Eldin Optimized quercetin-loaded glycerohyalurosome hydrogel: an innovative nanoplatform for enhanced wound healing Future Journal of Pharmaceutical Sciences Quercetin Glycerohyalurosomes Hydrogel Wound healing D-optimal design Drug delivery |
| title | Optimized quercetin-loaded glycerohyalurosome hydrogel: an innovative nanoplatform for enhanced wound healing |
| title_full | Optimized quercetin-loaded glycerohyalurosome hydrogel: an innovative nanoplatform for enhanced wound healing |
| title_fullStr | Optimized quercetin-loaded glycerohyalurosome hydrogel: an innovative nanoplatform for enhanced wound healing |
| title_full_unstemmed | Optimized quercetin-loaded glycerohyalurosome hydrogel: an innovative nanoplatform for enhanced wound healing |
| title_short | Optimized quercetin-loaded glycerohyalurosome hydrogel: an innovative nanoplatform for enhanced wound healing |
| title_sort | optimized quercetin loaded glycerohyalurosome hydrogel an innovative nanoplatform for enhanced wound healing |
| topic | Quercetin Glycerohyalurosomes Hydrogel Wound healing D-optimal design Drug delivery |
| url | https://doi.org/10.1186/s43094-025-00808-4 |
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