A model qualification method for mechanistic physiological QSP models to support model‐informed drug development
Mechanistic physiological modeling is a scientific method that combines available data with scientific knowledge and engineering approaches to facilitate better understanding of biological systems, improve decision‐making, reduce risk, and increase efficiency in drug discovery and development. It is...
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| Format: | Article |
| Language: | English |
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Wiley
2016-02-01
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| Series: | CPT: Pharmacometrics & Systems Pharmacology |
| Online Access: | https://doi.org/10.1002/psp4.12056 |
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| _version_ | 1849703550593007616 |
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| author | CM Friedrich |
| author_facet | CM Friedrich |
| author_sort | CM Friedrich |
| collection | DOAJ |
| description | Mechanistic physiological modeling is a scientific method that combines available data with scientific knowledge and engineering approaches to facilitate better understanding of biological systems, improve decision‐making, reduce risk, and increase efficiency in drug discovery and development. It is a type of quantitative systems pharmacology (QSP) approach that places drug‐specific properties in the context of disease biology. This tutorial provides a broadly applicable model qualification method (MQM) to ensure that mechanistic physiological models are fit for their intended purposes. |
| format | Article |
| id | doaj-art-aff080760348455ebdd404628ee49a2b |
| institution | DOAJ |
| issn | 2163-8306 |
| language | English |
| publishDate | 2016-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | CPT: Pharmacometrics & Systems Pharmacology |
| spelling | doaj-art-aff080760348455ebdd404628ee49a2b2025-08-20T03:17:14ZengWileyCPT: Pharmacometrics & Systems Pharmacology2163-83062016-02-0152435310.1002/psp4.12056A model qualification method for mechanistic physiological QSP models to support model‐informed drug developmentCM Friedrich0Rosa & Co, LLCSan Francisco California USAMechanistic physiological modeling is a scientific method that combines available data with scientific knowledge and engineering approaches to facilitate better understanding of biological systems, improve decision‐making, reduce risk, and increase efficiency in drug discovery and development. It is a type of quantitative systems pharmacology (QSP) approach that places drug‐specific properties in the context of disease biology. This tutorial provides a broadly applicable model qualification method (MQM) to ensure that mechanistic physiological models are fit for their intended purposes.https://doi.org/10.1002/psp4.12056 |
| spellingShingle | CM Friedrich A model qualification method for mechanistic physiological QSP models to support model‐informed drug development CPT: Pharmacometrics & Systems Pharmacology |
| title | A model qualification method for mechanistic physiological QSP models to support model‐informed drug development |
| title_full | A model qualification method for mechanistic physiological QSP models to support model‐informed drug development |
| title_fullStr | A model qualification method for mechanistic physiological QSP models to support model‐informed drug development |
| title_full_unstemmed | A model qualification method for mechanistic physiological QSP models to support model‐informed drug development |
| title_short | A model qualification method for mechanistic physiological QSP models to support model‐informed drug development |
| title_sort | model qualification method for mechanistic physiological qsp models to support model informed drug development |
| url | https://doi.org/10.1002/psp4.12056 |
| work_keys_str_mv | AT cmfriedrich amodelqualificationmethodformechanisticphysiologicalqspmodelstosupportmodelinformeddrugdevelopment AT cmfriedrich modelqualificationmethodformechanisticphysiologicalqspmodelstosupportmodelinformeddrugdevelopment |