Hierarchy and interconnected networks in the WhiB7 mediated transcriptional response to antibiotic stress in Mycobacterium abscessus.

Mycobacterium abscessus is intrinsically resistant to antibiotics effective against other pathogenic mycobacteria largely due to the drug-induced expression of genes that confer resistance. WhiB7 is a major hub controlling the induction of resistance to ribosome-targeting antibiotics. It activates t...

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Bibliographic Details
Main Authors: Kelley Hurst-Hess, Charity McManaman, Yong Yang, Shamba Gupta, Pallavi Ghosh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-12-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1011060&type=printable
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