Chronic Lymphocytic Leukemia Involving the Liver Without High-Grade Transformation
Chronic lymphocytic leukemia is most frequently encountered among the elderly population. Hepatic infiltration may be present at the time of diagnosis, but significant extranodal involvement rarely occurs without high-grade transformation. Abnormal liver enzymes have important prognostic implication...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2022-09-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0409 |
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| _version_ | 1850147905948614656 |
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| author | Alexandra V. Kimchy William D. Davis Megan E. Murphy Melinda G. Fang Annie J. Kruger James H. Lewis |
| author_facet | Alexandra V. Kimchy William D. Davis Megan E. Murphy Melinda G. Fang Annie J. Kruger James H. Lewis |
| author_sort | Alexandra V. Kimchy |
| collection | DOAJ |
| description | Chronic lymphocytic leukemia is most frequently encountered among the elderly population. Hepatic infiltration may be present at the time of diagnosis, but significant extranodal involvement rarely occurs without high-grade transformation. Abnormal liver enzymes have important prognostic implications in terms of staging the disease and initiating treatment. We describe an atypical presentation of chronic lymphocytic leukemia in a patient who presented with rising liver enzyme levels, extensive hepatic infiltration, and portal hypertension but with no evidence of high-grade transformation on liver biopsy. |
| format | Article |
| id | doaj-art-afef9d82f1484f498227e690d8d46e45 |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-afef9d82f1484f498227e690d8d46e452025-08-20T02:27:24ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642022-09-011710.7326/aimcc.2022.0409Chronic Lymphocytic Leukemia Involving the Liver Without High-Grade TransformationAlexandra V. Kimchy0William D. Davis1Megan E. Murphy2Melinda G. Fang3Annie J. Kruger4James H. Lewis51Department of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC1Department of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC2Department of Gastroenterology, MedStar Georgetown University Hospital, Washington, DC3Department of Pathology, MedStar Georgetown University Hospital, Washington, DC2Department of Gastroenterology, MedStar Georgetown University Hospital, Washington, DC2Department of Gastroenterology, MedStar Georgetown University Hospital, Washington, DCChronic lymphocytic leukemia is most frequently encountered among the elderly population. Hepatic infiltration may be present at the time of diagnosis, but significant extranodal involvement rarely occurs without high-grade transformation. Abnormal liver enzymes have important prognostic implications in terms of staging the disease and initiating treatment. We describe an atypical presentation of chronic lymphocytic leukemia in a patient who presented with rising liver enzyme levels, extensive hepatic infiltration, and portal hypertension but with no evidence of high-grade transformation on liver biopsy.https://www.acpjournals.org/doi/10.7326/aimcc.2022.0409 |
| spellingShingle | Alexandra V. Kimchy William D. Davis Megan E. Murphy Melinda G. Fang Annie J. Kruger James H. Lewis Chronic Lymphocytic Leukemia Involving the Liver Without High-Grade Transformation Annals of Internal Medicine: Clinical Cases |
| title | Chronic Lymphocytic Leukemia Involving the Liver Without High-Grade Transformation |
| title_full | Chronic Lymphocytic Leukemia Involving the Liver Without High-Grade Transformation |
| title_fullStr | Chronic Lymphocytic Leukemia Involving the Liver Without High-Grade Transformation |
| title_full_unstemmed | Chronic Lymphocytic Leukemia Involving the Liver Without High-Grade Transformation |
| title_short | Chronic Lymphocytic Leukemia Involving the Liver Without High-Grade Transformation |
| title_sort | chronic lymphocytic leukemia involving the liver without high grade transformation |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0409 |
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