Gunshot liver injuries grade I-III and related liver enzyme values
Background/Aim. The liver is one of the most commonly injured solid organ in patients with abdominal gunshot wounds. The aim of this study was to investigate correlation between aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels as well as correlation between liver enzymes an...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2018-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2018/0042-84501700042R.pdf |
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| author | Radunović Miodrag Vuković Marko Radojević Nemanja Lazović Ranko Radunović Miroslav |
| author_facet | Radunović Miodrag Vuković Marko Radojević Nemanja Lazović Ranko Radunović Miroslav |
| author_sort | Radunović Miodrag |
| collection | DOAJ |
| description | Background/Aim. The liver is one of the most commonly injured solid organ in patients with abdominal gunshot wounds. The aim of this study was to investigate correlation between aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels as well as correlation between liver enzymes and Injury Severity Score (ISS) among patients sustained a gunshot liver injury. Methods. The study included 30 patients with a gunshot liver injury. Patients were divided into three groups, according to the American Association for the Surgery of Trauma injury grade. We included only patients with first (I), second (II) and third degree (III) injury. AST and ALT levels were also initially measured, and then consecutively each day, up to the fifth post-traumatic day, in order to determine which of them is better and more stable predictor of severity of gunshot liver injury. Results. ALT had significant positive correlation with a low-degree gunshot liver injury, on the day zero, post-traumatic day one and day two. Nevertheless, AST/ALT relation throughout post-traumatic five day period regarding an injury grade correlates best in II grade injury. At the end, strong positive correlation between ALT and ISS was observed (p < 0.05). Conclusion. Presented data clearly shows that ALT is better gunshot liver injury predictor than AST, with strong predictive value regarding injury severity, in first days after liver trauma. Therefore, it could be easily available, cheap and reliable prognostic tool for complexity of liver trauma. ALT prediction value is more significant for I and II injury, grade. Correlation between AST and ALT exists only for specific injury grade (II), but not in general. |
| format | Article |
| id | doaj-art-afebf79fdb9d4120a4ca232084ad50c2 |
| institution | Kabale University |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-afebf79fdb9d4120a4ca232084ad50c22025-08-20T03:39:14ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202018-01-0175111106110910.2298/VSP161215042R0042-84501700042RGunshot liver injuries grade I-III and related liver enzyme valuesRadunović Miodrag0Vuković Marko1Radojević Nemanja2Lazović Ranko3Radunović Miroslav4Clinical Centre of Montenegro, Podgorica, MontenegroClinical Centre of Montenegro, Podgorica, MontenegroClinical Centre of Montenegro, Podgorica, MontenegroClinical Centre of Montenegro, Podgorica, MontenegroUniversity of Montenegro, Faculty of Medicine, Podgorica, MontenegroBackground/Aim. The liver is one of the most commonly injured solid organ in patients with abdominal gunshot wounds. The aim of this study was to investigate correlation between aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels as well as correlation between liver enzymes and Injury Severity Score (ISS) among patients sustained a gunshot liver injury. Methods. The study included 30 patients with a gunshot liver injury. Patients were divided into three groups, according to the American Association for the Surgery of Trauma injury grade. We included only patients with first (I), second (II) and third degree (III) injury. AST and ALT levels were also initially measured, and then consecutively each day, up to the fifth post-traumatic day, in order to determine which of them is better and more stable predictor of severity of gunshot liver injury. Results. ALT had significant positive correlation with a low-degree gunshot liver injury, on the day zero, post-traumatic day one and day two. Nevertheless, AST/ALT relation throughout post-traumatic five day period regarding an injury grade correlates best in II grade injury. At the end, strong positive correlation between ALT and ISS was observed (p < 0.05). Conclusion. Presented data clearly shows that ALT is better gunshot liver injury predictor than AST, with strong predictive value regarding injury severity, in first days after liver trauma. Therefore, it could be easily available, cheap and reliable prognostic tool for complexity of liver trauma. ALT prediction value is more significant for I and II injury, grade. Correlation between AST and ALT exists only for specific injury grade (II), but not in general.http://www.doiserbia.nb.rs/img/doi/0042-8450/2018/0042-84501700042R.pdfwounds, gunshotliverinjury severity scoretransaminases |
| spellingShingle | Radunović Miodrag Vuković Marko Radojević Nemanja Lazović Ranko Radunović Miroslav Gunshot liver injuries grade I-III and related liver enzyme values Vojnosanitetski Pregled wounds, gunshot liver injury severity score transaminases |
| title | Gunshot liver injuries grade I-III and related liver enzyme values |
| title_full | Gunshot liver injuries grade I-III and related liver enzyme values |
| title_fullStr | Gunshot liver injuries grade I-III and related liver enzyme values |
| title_full_unstemmed | Gunshot liver injuries grade I-III and related liver enzyme values |
| title_short | Gunshot liver injuries grade I-III and related liver enzyme values |
| title_sort | gunshot liver injuries grade i iii and related liver enzyme values |
| topic | wounds, gunshot liver injury severity score transaminases |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2018/0042-84501700042R.pdf |
| work_keys_str_mv | AT radunovicmiodrag gunshotliverinjuriesgradeiiiiandrelatedliverenzymevalues AT vukovicmarko gunshotliverinjuriesgradeiiiiandrelatedliverenzymevalues AT radojevicnemanja gunshotliverinjuriesgradeiiiiandrelatedliverenzymevalues AT lazovicranko gunshotliverinjuriesgradeiiiiandrelatedliverenzymevalues AT radunovicmiroslav gunshotliverinjuriesgradeiiiiandrelatedliverenzymevalues |