HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia
Background and Objectives. Numerous genome-wide association studies have highlighted that chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder with an important genetic component. An important number of genes have been implicated in CLL etiology, with some of the most important being...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | Genetics Research |
| Online Access: | http://dx.doi.org/10.1155/2024/8852876 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849396759507238912 |
|---|---|
| author | Maria Tizu Bogdan Calenic Mihai Hârza Bogdan M. Cristea Ion Maruntelu Andreea M. Caragea Adriana Talangescu Alina Dima Alexandra E. Constantinescu Ileana Constantinescu |
| author_facet | Maria Tizu Bogdan Calenic Mihai Hârza Bogdan M. Cristea Ion Maruntelu Andreea M. Caragea Adriana Talangescu Alina Dima Alexandra E. Constantinescu Ileana Constantinescu |
| author_sort | Maria Tizu |
| collection | DOAJ |
| description | Background and Objectives. Numerous genome-wide association studies have highlighted that chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder with an important genetic component. An important number of genes have been implicated in CLL etiology, with some of the most important being human leukocyte antigen (HLA) genes. The aim of this study was to analyze the association of CLL with certain HLA alleles in the Romanian population and to compare our results with previous findings. Materials and Methods. This study included 66 patients with CLL, diagnosed between 2020 and 2022, and 100 healthy controls. HLA class I and class II genes (HLA-A/B/C, HLA-DQA1/DQB1/DPA1/DPB1, and HLA-DRB1/3/4/5) were investigated using next-generation sequencing technology. Results. Several HLA alleles were strongly associated with CLL. The most important finding was that HLA-DRB1∗04:02:01 (p=0.001, OR = 1.05) and HLA-DRB3∗02:01:01 (p=0.009, OR = 1.03) have a predisposing role in CLL development. Moreover, we identified that HLA-A∗24:02:01 0.01 (p=0.01, OR = 0.38), HLA-DQA1∗05:05:01 (p=0.01, OR = 0.56), HLA-DQB1∗03:02:01 (p=0.03, OR = 0.40), and HLA-DRB4∗01:03:01 (p=0.03, OR = 0.54 alleles have protective roles. Correlations between HLA expression and gender showed that women had a higher expression of protective HLA alleles when compared to men. Conclusions. Our data are the first to indicate that in Romanian patients with CLL, the HLA-A∗24:02:01 and HLA-DQA1∗05:05:01 alleles have a protective role against CLL development, whereas HLA-DRB1∗04:02:01 and HLA-DRB3∗02:01:01alleles are positively associated with CLL. |
| format | Article |
| id | doaj-art-afe916d7130b49af8277b3c5f14ed0ff |
| institution | Kabale University |
| issn | 1469-5073 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Genetics Research |
| spelling | doaj-art-afe916d7130b49af8277b3c5f14ed0ff2025-08-20T03:39:14ZengWileyGenetics Research1469-50732024-01-01202410.1155/2024/8852876HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic LeukemiaMaria Tizu0Bogdan Calenic1Mihai Hârza2Bogdan M. Cristea3Ion Maruntelu4Andreea M. Caragea5Adriana Talangescu6Alina Dima7Alexandra E. Constantinescu8Ileana Constantinescu9Immunology and Transplant ImmunologyImmunology and Transplant ImmunologyImmunology and Transplant ImmunologyImmunology and Transplant ImmunologyCentre of Immunogenetics and VirologyImmunology and Transplant ImmunologyCentre of Immunogenetics and VirologyColentina Clinical HospitalImmunology and Transplant ImmunologyImmunology and Transplant ImmunologyBackground and Objectives. Numerous genome-wide association studies have highlighted that chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder with an important genetic component. An important number of genes have been implicated in CLL etiology, with some of the most important being human leukocyte antigen (HLA) genes. The aim of this study was to analyze the association of CLL with certain HLA alleles in the Romanian population and to compare our results with previous findings. Materials and Methods. This study included 66 patients with CLL, diagnosed between 2020 and 2022, and 100 healthy controls. HLA class I and class II genes (HLA-A/B/C, HLA-DQA1/DQB1/DPA1/DPB1, and HLA-DRB1/3/4/5) were investigated using next-generation sequencing technology. Results. Several HLA alleles were strongly associated with CLL. The most important finding was that HLA-DRB1∗04:02:01 (p=0.001, OR = 1.05) and HLA-DRB3∗02:01:01 (p=0.009, OR = 1.03) have a predisposing role in CLL development. Moreover, we identified that HLA-A∗24:02:01 0.01 (p=0.01, OR = 0.38), HLA-DQA1∗05:05:01 (p=0.01, OR = 0.56), HLA-DQB1∗03:02:01 (p=0.03, OR = 0.40), and HLA-DRB4∗01:03:01 (p=0.03, OR = 0.54 alleles have protective roles. Correlations between HLA expression and gender showed that women had a higher expression of protective HLA alleles when compared to men. Conclusions. Our data are the first to indicate that in Romanian patients with CLL, the HLA-A∗24:02:01 and HLA-DQA1∗05:05:01 alleles have a protective role against CLL development, whereas HLA-DRB1∗04:02:01 and HLA-DRB3∗02:01:01alleles are positively associated with CLL.http://dx.doi.org/10.1155/2024/8852876 |
| spellingShingle | Maria Tizu Bogdan Calenic Mihai Hârza Bogdan M. Cristea Ion Maruntelu Andreea M. Caragea Adriana Talangescu Alina Dima Alexandra E. Constantinescu Ileana Constantinescu HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia Genetics Research |
| title | HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia |
| title_full | HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia |
| title_fullStr | HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia |
| title_full_unstemmed | HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia |
| title_short | HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia |
| title_sort | hla gene polymorphisms in romanian patients with chronic lymphocytic leukemia |
| url | http://dx.doi.org/10.1155/2024/8852876 |
| work_keys_str_mv | AT mariatizu hlagenepolymorphismsinromanianpatientswithchroniclymphocyticleukemia AT bogdancalenic hlagenepolymorphismsinromanianpatientswithchroniclymphocyticleukemia AT mihaiharza hlagenepolymorphismsinromanianpatientswithchroniclymphocyticleukemia AT bogdanmcristea hlagenepolymorphismsinromanianpatientswithchroniclymphocyticleukemia AT ionmaruntelu hlagenepolymorphismsinromanianpatientswithchroniclymphocyticleukemia AT andreeamcaragea hlagenepolymorphismsinromanianpatientswithchroniclymphocyticleukemia AT adrianatalangescu hlagenepolymorphismsinromanianpatientswithchroniclymphocyticleukemia AT alinadima hlagenepolymorphismsinromanianpatientswithchroniclymphocyticleukemia AT alexandraeconstantinescu hlagenepolymorphismsinromanianpatientswithchroniclymphocyticleukemia AT ileanaconstantinescu hlagenepolymorphismsinromanianpatientswithchroniclymphocyticleukemia |