Radiological Reporting of Brain Atrophy in MRI: Real-Life Comparison Between Narrative Reports, Semiquantitative Scales and Automated Software-Based Volumetry
<b>Background</b>: Accurate assessment of brain atrophy is essential in the diagnosis and monitoring of brain aging and neurodegenerative disorders. Radiological methods range from narrative reporting to semi-quantitative visual rating scales (VRSs) and fully automated volumetric softwar...
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MDPI AG
2025-05-01
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| author | Federico Bruno Cristina Fagotti Gaspare Saltarelli Giovanni Di Cerbo Alessandra Sabatelli Claudia De Felici Antonio Innocenzi Ernesto Di Cesare Alessandra Splendiani |
| author_facet | Federico Bruno Cristina Fagotti Gaspare Saltarelli Giovanni Di Cerbo Alessandra Sabatelli Claudia De Felici Antonio Innocenzi Ernesto Di Cesare Alessandra Splendiani |
| author_sort | Federico Bruno |
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| description | <b>Background</b>: Accurate assessment of brain atrophy is essential in the diagnosis and monitoring of brain aging and neurodegenerative disorders. Radiological methods range from narrative reporting to semi-quantitative visual rating scales (VRSs) and fully automated volumetric software. However, their integration and consistency in clinical practice remain limited. <b>Methods</b>: In this retrospective study, brain MRI images of 43 patients were evaluated. Brain atrophy was assessed by extrapolating findings from narrative radiology reports, three validated VRSs (MTA, Koedam, Pasquier), and Pixyl.Neuro.BV, a commercially available volumetric software platform. Agreement between methods was assessed using intraclass correlation coefficients (ICCs), Cohen’s kappa, Spearman’s correlation, and McNemar tests. <b>Results</b>: Moderate correlation was found between narrative reports and VRSs (ρ = 0.55–0.69), but categorical agreement was limited (kappa = 0.21–0.30). Visual scales underestimated atrophy relative to software (mean scores: VRSs = 0.196; software = 0.279), while reports tended to overestimate. Agreement between VRSs and software was poor (kappa = 0.14–0.33), though MTA showed a significant correlation with hippocampal volume. Agreement between reports and software was lowest for global atrophy. <b>Conclusions</b>: Narrative reports, while common in practice, show low consistency with structured scales and quantitative software, especially in subtle cases. VRSs improve standardization but remain subjective and less sensitive. Integrating structured scales and volumetric tools into clinical workflows may enhance diagnostic accuracy and consistency in dementia imaging. |
| format | Article |
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| issn | 2075-4418 |
| language | English |
| publishDate | 2025-05-01 |
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| series | Diagnostics |
| spelling | doaj-art-afe65ed170834e2085c7ba7256c901662025-08-20T01:56:16ZengMDPI AGDiagnostics2075-44182025-05-011510124610.3390/diagnostics15101246Radiological Reporting of Brain Atrophy in MRI: Real-Life Comparison Between Narrative Reports, Semiquantitative Scales and Automated Software-Based VolumetryFederico Bruno0Cristina Fagotti1Gaspare Saltarelli2Giovanni Di Cerbo3Alessandra Sabatelli4Claudia De Felici5Antonio Innocenzi6Ernesto Di Cesare7Alessandra Splendiani8Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, Italy<b>Background</b>: Accurate assessment of brain atrophy is essential in the diagnosis and monitoring of brain aging and neurodegenerative disorders. Radiological methods range from narrative reporting to semi-quantitative visual rating scales (VRSs) and fully automated volumetric software. However, their integration and consistency in clinical practice remain limited. <b>Methods</b>: In this retrospective study, brain MRI images of 43 patients were evaluated. Brain atrophy was assessed by extrapolating findings from narrative radiology reports, three validated VRSs (MTA, Koedam, Pasquier), and Pixyl.Neuro.BV, a commercially available volumetric software platform. Agreement between methods was assessed using intraclass correlation coefficients (ICCs), Cohen’s kappa, Spearman’s correlation, and McNemar tests. <b>Results</b>: Moderate correlation was found between narrative reports and VRSs (ρ = 0.55–0.69), but categorical agreement was limited (kappa = 0.21–0.30). Visual scales underestimated atrophy relative to software (mean scores: VRSs = 0.196; software = 0.279), while reports tended to overestimate. Agreement between VRSs and software was poor (kappa = 0.14–0.33), though MTA showed a significant correlation with hippocampal volume. Agreement between reports and software was lowest for global atrophy. <b>Conclusions</b>: Narrative reports, while common in practice, show low consistency with structured scales and quantitative software, especially in subtle cases. VRSs improve standardization but remain subjective and less sensitive. Integrating structured scales and volumetric tools into clinical workflows may enhance diagnostic accuracy and consistency in dementia imaging.https://www.mdpi.com/2075-4418/15/10/1246MRIdementiabrain atrophybrain volumetryautomated software |
| spellingShingle | Federico Bruno Cristina Fagotti Gaspare Saltarelli Giovanni Di Cerbo Alessandra Sabatelli Claudia De Felici Antonio Innocenzi Ernesto Di Cesare Alessandra Splendiani Radiological Reporting of Brain Atrophy in MRI: Real-Life Comparison Between Narrative Reports, Semiquantitative Scales and Automated Software-Based Volumetry Diagnostics MRI dementia brain atrophy brain volumetry automated software |
| title | Radiological Reporting of Brain Atrophy in MRI: Real-Life Comparison Between Narrative Reports, Semiquantitative Scales and Automated Software-Based Volumetry |
| title_full | Radiological Reporting of Brain Atrophy in MRI: Real-Life Comparison Between Narrative Reports, Semiquantitative Scales and Automated Software-Based Volumetry |
| title_fullStr | Radiological Reporting of Brain Atrophy in MRI: Real-Life Comparison Between Narrative Reports, Semiquantitative Scales and Automated Software-Based Volumetry |
| title_full_unstemmed | Radiological Reporting of Brain Atrophy in MRI: Real-Life Comparison Between Narrative Reports, Semiquantitative Scales and Automated Software-Based Volumetry |
| title_short | Radiological Reporting of Brain Atrophy in MRI: Real-Life Comparison Between Narrative Reports, Semiquantitative Scales and Automated Software-Based Volumetry |
| title_sort | radiological reporting of brain atrophy in mri real life comparison between narrative reports semiquantitative scales and automated software based volumetry |
| topic | MRI dementia brain atrophy brain volumetry automated software |
| url | https://www.mdpi.com/2075-4418/15/10/1246 |
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