Intrathecal pemetrexed chemotherapy combined with systemic therapy in patients with non-small cell lung cancer and leptomeningeal metastases: a retrospective study

Intrathecal pemetrexed chemotherapy combined with systemic therapy in patients with non-small cell lung cancer and leptomeningeal metastases: a retrospective study

BackgroundLeptomeningeal metastases (LM) in non-small cell lung cancer (NSCLC) present a challenging prognosis, with systemic therapies often limited by the blood-brain barrier. However, intrathecal pemetrexed injections can increase intracranial drug concentrations, aiding in disease control.Object...

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Bibliographic Details
Main Authors: Wenjuan Zhong, Longqiu Wu, Zhengang Qiu, Wei Yu, Linfang Liu, Huaqiu Shi, Shugui Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Oncology
Subjects:
non-small cell lung cancer
leptomeningeal metastases
pemetrexed
intrathecal chemotherapy
EGFR
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1545174/full
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