Serum cytokines as a biomarker for immune checkpoint inhibitor toxicity in patients with pleural mesothelioma

Serum cytokines as a biomarker for immune checkpoint inhibitor toxicity in patients with pleural mesothelioma

BackgroundPleural mesothelioma (PM) is a rare cancer with a dismal prognosis. Dual immune checkpoint inhibitors have improved overall survival, but the rate of immune-related adverse events (irAEs) is high. Serum cytokines reflect systemic immune reactions and may serve as biomarkers for irAEs.Patie...

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Bibliographic Details
Main Authors: Saima Jamil Farooqi, Zhi Zhao, Åsa Kristina Öjlert, Solfrid Thunold, Hedvig Vidarsdotter Juul, Maria Moksnes Bjaanæs, Henrik Horndalsveen, Hanne Marte Gjertsen Nymoen, Åslaug Helland, Vilde Drageset Haakensen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
pleural mesothelioma
immunotherapy
biomarkers
cytokines
checkpoint inhibition blockade
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1480183/full
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