Extranodal Marginal Zone Lymphoma Presenting as Acute Kidney Injury due to Cast Nephropathy: A Case Report
Acute kidney injury (AKI) in non-Hodgkin lymphoma has diverse etiologies. We report a case in which AKI due to light chain cast nephropathy was the initial manifestation of extranodal marginal zone lymphoma, occurring without systemic symptoms. A 64-year-old male presented with severe AKI without ot...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2025-06-01
|
| Series: | Canadian Journal of Kidney Health and Disease |
| Online Access: | https://doi.org/10.1177/20543581251338434 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849470989807648768 |
|---|---|
| author | Naphasorn Naruemon Piriyaporn Iamsai Piyapong Ounpanyo Boonyarit Cheunsuchon Thanawat Vongchaiudomchoke |
| author_facet | Naphasorn Naruemon Piriyaporn Iamsai Piyapong Ounpanyo Boonyarit Cheunsuchon Thanawat Vongchaiudomchoke |
| author_sort | Naphasorn Naruemon |
| collection | DOAJ |
| description | Acute kidney injury (AKI) in non-Hodgkin lymphoma has diverse etiologies. We report a case in which AKI due to light chain cast nephropathy was the initial manifestation of extranodal marginal zone lymphoma, occurring without systemic symptoms. A 64-year-old male presented with severe AKI without other symptoms. His physical examination and renal ultrasound were unremarkable. Renal biopsy revealed light chain cast nephropathy, and a subsequent bone marrow biopsy confirmed marginal zone lymphoma. The patient received R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) for a total of six cycles. The patient had a partial response to lymphoma. However, his renal function did not improve, and ultimately he progressed to end-stage kidney disease, requiring maintenance hemodialysis. This case highlights extranodal marginal zone lymphoma presenting as AKI, emphasizing its unique renal-limited manifestation in the absence of systemic symptoms and the critical role of renal biopsy in diagnosing unexplained AKI. |
| format | Article |
| id | doaj-art-afdaea65da014ee19f9b831c8162bd40 |
| institution | Kabale University |
| issn | 2054-3581 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Canadian Journal of Kidney Health and Disease |
| spelling | doaj-art-afdaea65da014ee19f9b831c8162bd402025-08-20T03:24:59ZengSAGE PublishingCanadian Journal of Kidney Health and Disease2054-35812025-06-011210.1177/20543581251338434Extranodal Marginal Zone Lymphoma Presenting as Acute Kidney Injury due to Cast Nephropathy: A Case ReportNaphasorn Naruemon0Piriyaporn Iamsai1Piyapong Ounpanyo2Boonyarit Cheunsuchon3Thanawat Vongchaiudomchoke4Department of Internal Medicine, Lampang Hospital, Lampang, ThailandDepartment of Internal Medicine, Lampang Hospital, Lampang, ThailandDepartment of Anatomical Pathology, Lampang Hospital, Lampang, ThailandDivision of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Internal Medicine, Lampang Hospital, Lampang, ThailandAcute kidney injury (AKI) in non-Hodgkin lymphoma has diverse etiologies. We report a case in which AKI due to light chain cast nephropathy was the initial manifestation of extranodal marginal zone lymphoma, occurring without systemic symptoms. A 64-year-old male presented with severe AKI without other symptoms. His physical examination and renal ultrasound were unremarkable. Renal biopsy revealed light chain cast nephropathy, and a subsequent bone marrow biopsy confirmed marginal zone lymphoma. The patient received R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) for a total of six cycles. The patient had a partial response to lymphoma. However, his renal function did not improve, and ultimately he progressed to end-stage kidney disease, requiring maintenance hemodialysis. This case highlights extranodal marginal zone lymphoma presenting as AKI, emphasizing its unique renal-limited manifestation in the absence of systemic symptoms and the critical role of renal biopsy in diagnosing unexplained AKI.https://doi.org/10.1177/20543581251338434 |
| spellingShingle | Naphasorn Naruemon Piriyaporn Iamsai Piyapong Ounpanyo Boonyarit Cheunsuchon Thanawat Vongchaiudomchoke Extranodal Marginal Zone Lymphoma Presenting as Acute Kidney Injury due to Cast Nephropathy: A Case Report Canadian Journal of Kidney Health and Disease |
| title | Extranodal Marginal Zone Lymphoma Presenting as Acute Kidney Injury due to Cast Nephropathy: A Case Report |
| title_full | Extranodal Marginal Zone Lymphoma Presenting as Acute Kidney Injury due to Cast Nephropathy: A Case Report |
| title_fullStr | Extranodal Marginal Zone Lymphoma Presenting as Acute Kidney Injury due to Cast Nephropathy: A Case Report |
| title_full_unstemmed | Extranodal Marginal Zone Lymphoma Presenting as Acute Kidney Injury due to Cast Nephropathy: A Case Report |
| title_short | Extranodal Marginal Zone Lymphoma Presenting as Acute Kidney Injury due to Cast Nephropathy: A Case Report |
| title_sort | extranodal marginal zone lymphoma presenting as acute kidney injury due to cast nephropathy a case report |
| url | https://doi.org/10.1177/20543581251338434 |
| work_keys_str_mv | AT naphasornnaruemon extranodalmarginalzonelymphomapresentingasacutekidneyinjuryduetocastnephropathyacasereport AT piriyaporniamsai extranodalmarginalzonelymphomapresentingasacutekidneyinjuryduetocastnephropathyacasereport AT piyapongounpanyo extranodalmarginalzonelymphomapresentingasacutekidneyinjuryduetocastnephropathyacasereport AT boonyaritcheunsuchon extranodalmarginalzonelymphomapresentingasacutekidneyinjuryduetocastnephropathyacasereport AT thanawatvongchaiudomchoke extranodalmarginalzonelymphomapresentingasacutekidneyinjuryduetocastnephropathyacasereport |