Lower Frequency of CD62Lhigh and Higher Frequency of TNFR2+ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients
Diabetes type 1 is a chronic autoimmune disease in which insulin-producing cells are gradually destroyed by autoreactive T cells. Human regulatory cells play important role in controlling autoimmunity, and their qualitative or quantitative dysfunctions may result in ineffective suppression of autor...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2011/645643 |
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| author | Monika Ryba Karolina Rybarczyk-Kapturska Katarzyna Zorena Małgorzata Myśliwiec Jolanta Myśliwska |
| author_facet | Monika Ryba Karolina Rybarczyk-Kapturska Katarzyna Zorena Małgorzata Myśliwiec Jolanta Myśliwska |
| author_sort | Monika Ryba |
| collection | DOAJ |
| description | Diabetes type 1 is a chronic autoimmune disease in which insulin-producing cells are gradually destroyed by autoreactive T cells. Human regulatory cells play important role in controlling autoimmunity, and their qualitative or quantitative dysfunctions may result in ineffective suppression of autoreactive T cells. CD62L is a surface molecule that plays role in homing capabilities of Tregs, and only cells with high expression of CD62L have high suppressive potential. Tregs are also characterized by the constant expression of TNFR2. The frequency of Tregs carrying TNFR2 is higher in inflammatory conditions. We investigated blood regulatory T cells with CD62L expression and regulatory T cells expressing TNFR2 in type 1 diabetic patients. We found differences in these populations when comparing to healthy individuals. We propose that these may be associated with inflammatory conditions that are present in patients with type 1 diabetes. The lower percentage of Tregs and Treg CD62Lhigh may contribute to ineffective suppression of proinflammatory cytokines production during type 1 diabetes. |
| format | Article |
| id | doaj-art-afd8dd757b23483ca660c6e20fac9eaf |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-afd8dd757b23483ca660c6e20fac9eaf2025-02-03T06:42:01ZengWileyMediators of Inflammation0962-93511466-18612011-01-01201110.1155/2011/645643645643Lower Frequency of CD62Lhigh and Higher Frequency of TNFR2+ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic PatientsMonika Ryba0Karolina Rybarczyk-Kapturska1Katarzyna Zorena2Małgorzata Myśliwiec3Jolanta Myśliwska4Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, PolandDepartment of Immunology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, PolandDepartment of Immunology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, PolandDiabetological Department, Clinic of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdańsk, 80-210 Gdańsk, PolandDepartment of Immunology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, PolandDiabetes type 1 is a chronic autoimmune disease in which insulin-producing cells are gradually destroyed by autoreactive T cells. Human regulatory cells play important role in controlling autoimmunity, and their qualitative or quantitative dysfunctions may result in ineffective suppression of autoreactive T cells. CD62L is a surface molecule that plays role in homing capabilities of Tregs, and only cells with high expression of CD62L have high suppressive potential. Tregs are also characterized by the constant expression of TNFR2. The frequency of Tregs carrying TNFR2 is higher in inflammatory conditions. We investigated blood regulatory T cells with CD62L expression and regulatory T cells expressing TNFR2 in type 1 diabetic patients. We found differences in these populations when comparing to healthy individuals. We propose that these may be associated with inflammatory conditions that are present in patients with type 1 diabetes. The lower percentage of Tregs and Treg CD62Lhigh may contribute to ineffective suppression of proinflammatory cytokines production during type 1 diabetes.http://dx.doi.org/10.1155/2011/645643 |
| spellingShingle | Monika Ryba Karolina Rybarczyk-Kapturska Katarzyna Zorena Małgorzata Myśliwiec Jolanta Myśliwska Lower Frequency of CD62Lhigh and Higher Frequency of TNFR2+ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients Mediators of Inflammation |
| title | Lower Frequency of CD62Lhigh and Higher Frequency of TNFR2+ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients |
| title_full | Lower Frequency of CD62Lhigh and Higher Frequency of TNFR2+ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients |
| title_fullStr | Lower Frequency of CD62Lhigh and Higher Frequency of TNFR2+ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients |
| title_full_unstemmed | Lower Frequency of CD62Lhigh and Higher Frequency of TNFR2+ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients |
| title_short | Lower Frequency of CD62Lhigh and Higher Frequency of TNFR2+ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients |
| title_sort | lower frequency of cd62lhigh and higher frequency of tnfr2 tregs are associated with inflammatory conditions in type 1 diabetic patients |
| url | http://dx.doi.org/10.1155/2011/645643 |
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