The Role of Urinary Extracellular Vesicles in Kidney Cancer: Diagnostic and Therapeutic Potential
Renal cancer ranks as the 14th most common cancer globally, with renal cell carcinoma (RCC) being the primary variant, arising from renal tubular epithelial cells; clear cell RCC constitutes about 80% of cases. Despite their limitations, surgery and targeted therapy remain the mainstays of RCC treat...
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Asian Medical Press Ltd.(H.K.)
2024-07-01
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| Series: | Annals of Urologic Oncology |
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| Online Access: | http://auo.asmepress.com/articles/new-57-925.html |
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| author | Kirk Gallego |
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| description | Renal cancer ranks as the 14th most common cancer globally, with renal cell carcinoma (RCC) being the primary variant, arising from renal tubular epithelial cells; clear cell RCC constitutes about 80% of cases. Despite their limitations, surgery and targeted therapy remain the mainstays of RCC treatment. Regardless of advancements in RCC research, substantial obstacles continue to exist, such as delayed diagnosis, advanced distant metastasis, and drug resistance. As urine is an easily accessible biofluid, the identification of EVs has paved the way for novel biomarker research. Urinary extracellular vesicles (uEVs) are a novel source of biomarkers with potential applications in cancer detection and management, utilizing a less invasive approach. New data indicate that uEVs are crucial in several areas of RCC, containing tumor development, metastasis, immune evasion, and response to drugs. These vesicles facilitate intercellular communication by transporting a variety of bioactive substances, including RNA, DNA, proteins, and lipids, and are released into the extracellular space by the majority of cell types. uEVs RNAs and proteins are presently being investigated for their possible application as diagnostic biomarkers for different types of kidney cancer. This review summarizes the most recent research examining the potential of uEVs cargo as a biomarker for the diagnosis, prognosis, and treatment of renal cancer. |
| format | Article |
| id | doaj-art-afd0d00dbad04e598dcd7a0e63fd5fa8 |
| institution | DOAJ |
| issn | 2617-7765 2617-7773 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Asian Medical Press Ltd.(H.K.) |
| record_format | Article |
| series | Annals of Urologic Oncology |
| spelling | doaj-art-afd0d00dbad04e598dcd7a0e63fd5fa82025-08-20T02:48:42ZengAsian Medical Press Ltd.(H.K.)Annals of Urologic Oncology2617-77652617-77732024-07-01710.32948/auo.2024.10.25The Role of Urinary Extracellular Vesicles in Kidney Cancer: Diagnostic and Therapeutic PotentialKirk Gallego0Universidad de Montemorelos, Health Sciences Department, Montemorelos, N.L., Mexico.Renal cancer ranks as the 14th most common cancer globally, with renal cell carcinoma (RCC) being the primary variant, arising from renal tubular epithelial cells; clear cell RCC constitutes about 80% of cases. Despite their limitations, surgery and targeted therapy remain the mainstays of RCC treatment. Regardless of advancements in RCC research, substantial obstacles continue to exist, such as delayed diagnosis, advanced distant metastasis, and drug resistance. As urine is an easily accessible biofluid, the identification of EVs has paved the way for novel biomarker research. Urinary extracellular vesicles (uEVs) are a novel source of biomarkers with potential applications in cancer detection and management, utilizing a less invasive approach. New data indicate that uEVs are crucial in several areas of RCC, containing tumor development, metastasis, immune evasion, and response to drugs. These vesicles facilitate intercellular communication by transporting a variety of bioactive substances, including RNA, DNA, proteins, and lipids, and are released into the extracellular space by the majority of cell types. uEVs RNAs and proteins are presently being investigated for their possible application as diagnostic biomarkers for different types of kidney cancer. This review summarizes the most recent research examining the potential of uEVs cargo as a biomarker for the diagnosis, prognosis, and treatment of renal cancer.http://auo.asmepress.com/articles/new-57-925.htmlextracellular vesiclesurinary extracellular vesiclesrenal cell cancerurinebiomarker |
| spellingShingle | Kirk Gallego The Role of Urinary Extracellular Vesicles in Kidney Cancer: Diagnostic and Therapeutic Potential Annals of Urologic Oncology extracellular vesicles urinary extracellular vesicles renal cell cancer urine biomarker |
| title | The Role of Urinary Extracellular Vesicles in Kidney Cancer: Diagnostic and Therapeutic Potential |
| title_full | The Role of Urinary Extracellular Vesicles in Kidney Cancer: Diagnostic and Therapeutic Potential |
| title_fullStr | The Role of Urinary Extracellular Vesicles in Kidney Cancer: Diagnostic and Therapeutic Potential |
| title_full_unstemmed | The Role of Urinary Extracellular Vesicles in Kidney Cancer: Diagnostic and Therapeutic Potential |
| title_short | The Role of Urinary Extracellular Vesicles in Kidney Cancer: Diagnostic and Therapeutic Potential |
| title_sort | role of urinary extracellular vesicles in kidney cancer diagnostic and therapeutic potential |
| topic | extracellular vesicles urinary extracellular vesicles renal cell cancer urine biomarker |
| url | http://auo.asmepress.com/articles/new-57-925.html |
| work_keys_str_mv | AT kirkgallego theroleofurinaryextracellularvesiclesinkidneycancerdiagnosticandtherapeuticpotential AT kirkgallego roleofurinaryextracellularvesiclesinkidneycancerdiagnosticandtherapeuticpotential |