microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines
Abstract MicroRNAs (miRNAs) are single-stranded RNAs of 17–24 nt. These molecules regulate gene expression at the post-transcriptional level and are differentially expressed in viral acute respiratory infections (ARIs), which are responsible for high morbidity and mortality around the world. In rece...
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| Format: | Article |
| Language: | English |
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ELS Publishing (ELSP)
2019-02-01
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| Series: | ExRNA |
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| Online Access: | http://link.springer.com/article/10.1186/s41544-018-0004-7 |
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| author | Stephen A. Leon-Icaza Mingtao Zeng Adrian G. Rosas-Taraco |
| author_facet | Stephen A. Leon-Icaza Mingtao Zeng Adrian G. Rosas-Taraco |
| author_sort | Stephen A. Leon-Icaza |
| collection | DOAJ |
| description | Abstract MicroRNAs (miRNAs) are single-stranded RNAs of 17–24 nt. These molecules regulate gene expression at the post-transcriptional level and are differentially expressed in viral acute respiratory infections (ARIs), which are responsible for high morbidity and mortality around the world. In recent years, miRNAs have been studied in order to discover anti-viral ARI drug targets as well as biomarkers for diagnosis, severity, and prognosis. This review presents an analysis of the regulatory response to viral ARIs of miRNAs, including their participation in the innate immune response, their utility as biomarkers, and their potential for future therapies and vaccine development. |
| format | Article |
| id | doaj-art-afcf2bb487d44b668c222c523ce4a38d |
| institution | DOAJ |
| issn | 2398-0060 |
| language | English |
| publishDate | 2019-02-01 |
| publisher | ELS Publishing (ELSP) |
| record_format | Article |
| series | ExRNA |
| spelling | doaj-art-afcf2bb487d44b668c222c523ce4a38d2025-08-20T03:20:29ZengELS Publishing (ELSP)ExRNA2398-00602019-02-01111710.1186/s41544-018-0004-7microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccinesStephen A. Leon-Icaza0Mingtao Zeng1Adrian G. Rosas-Taraco2Department of Immunology, Faculty of Medicine, Universidad Autónoma de Nuevo LeónCenter of Emphasis in Infectious Diseases, Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El PasoDepartment of Immunology, Faculty of Medicine, Universidad Autónoma de Nuevo LeónAbstract MicroRNAs (miRNAs) are single-stranded RNAs of 17–24 nt. These molecules regulate gene expression at the post-transcriptional level and are differentially expressed in viral acute respiratory infections (ARIs), which are responsible for high morbidity and mortality around the world. In recent years, miRNAs have been studied in order to discover anti-viral ARI drug targets as well as biomarkers for diagnosis, severity, and prognosis. This review presents an analysis of the regulatory response to viral ARIs of miRNAs, including their participation in the innate immune response, their utility as biomarkers, and their potential for future therapies and vaccine development.http://link.springer.com/article/10.1186/s41544-018-0004-7miRNAViral ARIRhinovirusInfluenza virushMPVCoronavirus |
| spellingShingle | Stephen A. Leon-Icaza Mingtao Zeng Adrian G. Rosas-Taraco microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines ExRNA miRNA Viral ARI Rhinovirus Influenza virus hMPV Coronavirus |
| title | microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines |
| title_full | microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines |
| title_fullStr | microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines |
| title_full_unstemmed | microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines |
| title_short | microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines |
| title_sort | micrornas in viral acute respiratory infections immune regulation biomarkers therapy and vaccines |
| topic | miRNA Viral ARI Rhinovirus Influenza virus hMPV Coronavirus |
| url | http://link.springer.com/article/10.1186/s41544-018-0004-7 |
| work_keys_str_mv | AT stephenaleonicaza micrornasinviralacuterespiratoryinfectionsimmuneregulationbiomarkerstherapyandvaccines AT mingtaozeng micrornasinviralacuterespiratoryinfectionsimmuneregulationbiomarkerstherapyandvaccines AT adriangrosastaraco micrornasinviralacuterespiratoryinfectionsimmuneregulationbiomarkerstherapyandvaccines |