First report of Stemphylium lycopersici keratitis, a complex corneal infection case
Abstract Filamentous fungi are among the emerging causes of infections, although corneal infections caused by these fungi are rare, they can lead to severe clinical outcomes. In this report, we present the first documented case of keratitis caused by Stemphylium lycopersici, a filamentous hemipteran...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-05-01
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| Series: | Journal of Ophthalmic Inflammation and Infection |
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| Online Access: | https://doi.org/10.1186/s12348-025-00505-6 |
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| author | Zixiang Zhao Siyu Leng Yuhao Zou Lijuan Xiang Yunke Li Yi Liu Chongyang Wang Man Yu |
| author_facet | Zixiang Zhao Siyu Leng Yuhao Zou Lijuan Xiang Yunke Li Yi Liu Chongyang Wang Man Yu |
| author_sort | Zixiang Zhao |
| collection | DOAJ |
| description | Abstract Filamentous fungi are among the emerging causes of infections, although corneal infections caused by these fungi are rare, they can lead to severe clinical outcomes. In this report, we present the first documented case of keratitis caused by Stemphylium lycopersici, a filamentous hemipteran fungus of the Pleosporaceae family. A 66-year-old man presented conjunctival redness, irritation, and visual deterioration in his left eye, following a stone chip injury that occurred five months earlier. Despite multiple treatments, the causative pathogen remained unidentified, leading to worsening symptoms and significant vision loss. This deterioration led the patient to seek care at our hospital. An in vivo confocal microscopy (IVCM) examination suggested a fungal infection. Consequently, antifungal medications were administered, but the condition did not improve. Metagenomic next-generation sequencing (mNGS) examination of corneal scrapings revealed a mixed infection with S. lycopersici and human alphaherpesvirus 1. This definitive diagnosis facilitated the implementation of targeted therapy, leading to progressive symptomatic improvement. Early and rapid pathogen identification using mNGS analysis of corneal scrapings enables accurate management of infectious keratitis, contributing to visual recovery and reducing the risk of resistance to corneal pathogenic microbes. |
| format | Article |
| id | doaj-art-afceefafbad74c36a64ee81576e54d93 |
| institution | DOAJ |
| issn | 1869-5760 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Ophthalmic Inflammation and Infection |
| spelling | doaj-art-afceefafbad74c36a64ee81576e54d932025-08-20T03:16:32ZengSpringerOpenJournal of Ophthalmic Inflammation and Infection1869-57602025-05-011511710.1186/s12348-025-00505-6First report of Stemphylium lycopersici keratitis, a complex corneal infection caseZixiang Zhao0Siyu Leng1Yuhao Zou2Lijuan Xiang3Yunke Li4Yi Liu5Chongyang Wang6Man Yu7Department of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Ophthalmology, Chengdu BOE HospitalDepartment of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Ophthalmology, Deyang People’s HospitalDepartment of Ophthalmology, The First People’s Hospital of YibinDepartment of Ophthalmology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaAbstract Filamentous fungi are among the emerging causes of infections, although corneal infections caused by these fungi are rare, they can lead to severe clinical outcomes. In this report, we present the first documented case of keratitis caused by Stemphylium lycopersici, a filamentous hemipteran fungus of the Pleosporaceae family. A 66-year-old man presented conjunctival redness, irritation, and visual deterioration in his left eye, following a stone chip injury that occurred five months earlier. Despite multiple treatments, the causative pathogen remained unidentified, leading to worsening symptoms and significant vision loss. This deterioration led the patient to seek care at our hospital. An in vivo confocal microscopy (IVCM) examination suggested a fungal infection. Consequently, antifungal medications were administered, but the condition did not improve. Metagenomic next-generation sequencing (mNGS) examination of corneal scrapings revealed a mixed infection with S. lycopersici and human alphaherpesvirus 1. This definitive diagnosis facilitated the implementation of targeted therapy, leading to progressive symptomatic improvement. Early and rapid pathogen identification using mNGS analysis of corneal scrapings enables accurate management of infectious keratitis, contributing to visual recovery and reducing the risk of resistance to corneal pathogenic microbes.https://doi.org/10.1186/s12348-025-00505-6Fungal keratitisStemphylium lycopersiciMixed infectionNew pathogenic speciesAntibiotic resistance |
| spellingShingle | Zixiang Zhao Siyu Leng Yuhao Zou Lijuan Xiang Yunke Li Yi Liu Chongyang Wang Man Yu First report of Stemphylium lycopersici keratitis, a complex corneal infection case Journal of Ophthalmic Inflammation and Infection Fungal keratitis Stemphylium lycopersici Mixed infection New pathogenic species Antibiotic resistance |
| title | First report of Stemphylium lycopersici keratitis, a complex corneal infection case |
| title_full | First report of Stemphylium lycopersici keratitis, a complex corneal infection case |
| title_fullStr | First report of Stemphylium lycopersici keratitis, a complex corneal infection case |
| title_full_unstemmed | First report of Stemphylium lycopersici keratitis, a complex corneal infection case |
| title_short | First report of Stemphylium lycopersici keratitis, a complex corneal infection case |
| title_sort | first report of stemphylium lycopersici keratitis a complex corneal infection case |
| topic | Fungal keratitis Stemphylium lycopersici Mixed infection New pathogenic species Antibiotic resistance |
| url | https://doi.org/10.1186/s12348-025-00505-6 |
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