Comparative Immune Response in Children and Adults with H. pylori Infection
Helicobacter pylori (H. pylori) infection is generally acquired during early childhood; therefore, the immune response which usually takes place at this age may influence or even determine susceptibility to the infection contributing to the clinical outcomes in adulthood. Several cytokines including...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/315957 |
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| author | Alireza Razavi Nader Bagheri Fatemeh Azadegan-Dehkordi Mahsa Shirzad Ghorbanali Rahimian Mahmoud Rafieian-Kopaei Hedaytollah Shirzad |
| author_facet | Alireza Razavi Nader Bagheri Fatemeh Azadegan-Dehkordi Mahsa Shirzad Ghorbanali Rahimian Mahmoud Rafieian-Kopaei Hedaytollah Shirzad |
| author_sort | Alireza Razavi |
| collection | DOAJ |
| description | Helicobacter pylori (H. pylori) infection is generally acquired during early childhood; therefore, the immune response which usually takes place at this age may influence or even determine susceptibility to the infection contributing to the clinical outcomes in adulthood. Several cytokines including IL-6, IL-10, and TGF-β1 as well as Foxp3+ cell numbers have been shown to be higher; however, some other cytokines consisting of IL-1β, IL-17A, and IL-23 are lower in infected children than in infected adults. Immune response to H. pylori infection in children is predominant Treg instead of Th17 cell response. These results indicate that immune system responses probably play a role in persistent H. pylori infection. Childhood H. pylori infection is also associated with significantly lower levels of inflammation and ulceration compared with adults. This review, therefore, aimed to provide critical findings of the available literature about comparative immune system in children and adults with H. pylori infection. |
| format | Article |
| id | doaj-art-afcc925aa328487197d12a4cf115e5f0 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-afcc925aa328487197d12a4cf115e5f02025-08-20T02:19:06ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/315957315957Comparative Immune Response in Children and Adults with H. pylori InfectionAlireza Razavi0Nader Bagheri1Fatemeh Azadegan-Dehkordi2Mahsa Shirzad3Ghorbanali Rahimian4Mahmoud Rafieian-Kopaei5Hedaytollah Shirzad6Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranCellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranSchool of Dentistry, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, IranMedical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranCellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranHelicobacter pylori (H. pylori) infection is generally acquired during early childhood; therefore, the immune response which usually takes place at this age may influence or even determine susceptibility to the infection contributing to the clinical outcomes in adulthood. Several cytokines including IL-6, IL-10, and TGF-β1 as well as Foxp3+ cell numbers have been shown to be higher; however, some other cytokines consisting of IL-1β, IL-17A, and IL-23 are lower in infected children than in infected adults. Immune response to H. pylori infection in children is predominant Treg instead of Th17 cell response. These results indicate that immune system responses probably play a role in persistent H. pylori infection. Childhood H. pylori infection is also associated with significantly lower levels of inflammation and ulceration compared with adults. This review, therefore, aimed to provide critical findings of the available literature about comparative immune system in children and adults with H. pylori infection.http://dx.doi.org/10.1155/2015/315957 |
| spellingShingle | Alireza Razavi Nader Bagheri Fatemeh Azadegan-Dehkordi Mahsa Shirzad Ghorbanali Rahimian Mahmoud Rafieian-Kopaei Hedaytollah Shirzad Comparative Immune Response in Children and Adults with H. pylori Infection Journal of Immunology Research |
| title | Comparative Immune Response in Children and Adults with H. pylori Infection |
| title_full | Comparative Immune Response in Children and Adults with H. pylori Infection |
| title_fullStr | Comparative Immune Response in Children and Adults with H. pylori Infection |
| title_full_unstemmed | Comparative Immune Response in Children and Adults with H. pylori Infection |
| title_short | Comparative Immune Response in Children and Adults with H. pylori Infection |
| title_sort | comparative immune response in children and adults with h pylori infection |
| url | http://dx.doi.org/10.1155/2015/315957 |
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