In vitro activity of hybrid lavender essential oils against multidrug resistant strains of Pseudomonas aeruginosa
Introduction: Lavender is an evergreen shrub native to Northern Africa and other mountainous Mediterranean regions. It grows throughout Southern Europe, the United States, and Australia. Lavender essential oil has been used since ancient times and is known for its anti-inflammatory, antidepressant,...
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The Journal of Infection in Developing Countries
2018-01-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/9920 |
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| author | Matthew Donadu Donatella Usai Antonio Pinna Tiziana Porcu Vittorio Mazzarello Maura Fiamma Mauro Marchetti Sara Cannas Giovanni Delogu Stefania Zanetti Paola Molicotti |
| author_facet | Matthew Donadu Donatella Usai Antonio Pinna Tiziana Porcu Vittorio Mazzarello Maura Fiamma Mauro Marchetti Sara Cannas Giovanni Delogu Stefania Zanetti Paola Molicotti |
| author_sort | Matthew Donadu |
| collection | DOAJ |
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Introduction: Lavender is an evergreen shrub native to Northern Africa and other mountainous Mediterranean regions. It grows throughout Southern Europe, the United States, and Australia. Lavender essential oil has been used since ancient times and is known for its anti-inflammatory, antidepressant, antiseptic, antifungal and antimicrobial properties.
Methodology: in this study, the antimicrobial activity of two Lavender essential oils (Lavanda sumian and Lavanda grosso) against 16 multidrug-resistant P. aeruginosa strains from clinical ocular samples taken from migrant patients has been investigated. The in vitro cytotoxic activity on human Wong-Kilbourne derivative (WKD) conjunctiva cells from healthy patients and nitric oxide synthase (NOS) activity on murine macrophage (J774.1A) were also evaluated.
Results: L. sumian showed lower antimicrobial activity when compared to L. grosso. Both lavender oils tested had no cytotoxic effect at very low concentrations, mostly L. grosso. The essential oils extracted from L. sumian and L. grosso significantly reduced NOS in a cell model.
Conclusion: Increase in drug resistance and lack of new antibiotics may encourage the development of natural antimicrobial treatments.
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| format | Article |
| id | doaj-art-afcbb135dbd24772bc4e483f700f870c |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-afcbb135dbd24772bc4e483f700f870c2025-08-20T02:16:14ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802018-01-01120110.3855/jidc.9920In vitro activity of hybrid lavender essential oils against multidrug resistant strains of Pseudomonas aeruginosaMatthew Donadu0Donatella Usai1Antonio Pinna2Tiziana Porcu3Vittorio Mazzarello4Maura Fiamma5Mauro Marchetti6Sara Cannas7Giovanni Delogu8Stefania Zanetti9Paola Molicotti10University of Sassari, Sassari, ItalyUniversity of Sassari, Sassari, ItalyUniversity of Sassari, Sassari, ItalyUniversity of Sassari, Sassari, ItalyUniversity of Sassari, Sassari, ItalyUniversity of Sassari, Sassari, ItalyCNR, Institute of Biomolecular Chemistry, Li Punti, Sassari, ItalyUniversity of Sassari, Sassari, ItalySacro Cuore Catholic University, Rome, ItalyUniversity of Sassari, Sassari, ItalyUniversity of Sassari, Sassari, Italy Introduction: Lavender is an evergreen shrub native to Northern Africa and other mountainous Mediterranean regions. It grows throughout Southern Europe, the United States, and Australia. Lavender essential oil has been used since ancient times and is known for its anti-inflammatory, antidepressant, antiseptic, antifungal and antimicrobial properties. Methodology: in this study, the antimicrobial activity of two Lavender essential oils (Lavanda sumian and Lavanda grosso) against 16 multidrug-resistant P. aeruginosa strains from clinical ocular samples taken from migrant patients has been investigated. The in vitro cytotoxic activity on human Wong-Kilbourne derivative (WKD) conjunctiva cells from healthy patients and nitric oxide synthase (NOS) activity on murine macrophage (J774.1A) were also evaluated. Results: L. sumian showed lower antimicrobial activity when compared to L. grosso. Both lavender oils tested had no cytotoxic effect at very low concentrations, mostly L. grosso. The essential oils extracted from L. sumian and L. grosso significantly reduced NOS in a cell model. Conclusion: Increase in drug resistance and lack of new antibiotics may encourage the development of natural antimicrobial treatments. https://jidc.org/index.php/journal/article/view/9920Antimicrobials;Biopharmaceuticals;Cytotoxicity;Infection;Pseudomonads |
| spellingShingle | Matthew Donadu Donatella Usai Antonio Pinna Tiziana Porcu Vittorio Mazzarello Maura Fiamma Mauro Marchetti Sara Cannas Giovanni Delogu Stefania Zanetti Paola Molicotti In vitro activity of hybrid lavender essential oils against multidrug resistant strains of Pseudomonas aeruginosa Journal of Infection in Developing Countries Antimicrobials; Biopharmaceuticals; Cytotoxicity; Infection; Pseudomonads |
| title | In vitro activity of hybrid lavender essential oils against multidrug resistant strains of Pseudomonas aeruginosa |
| title_full | In vitro activity of hybrid lavender essential oils against multidrug resistant strains of Pseudomonas aeruginosa |
| title_fullStr | In vitro activity of hybrid lavender essential oils against multidrug resistant strains of Pseudomonas aeruginosa |
| title_full_unstemmed | In vitro activity of hybrid lavender essential oils against multidrug resistant strains of Pseudomonas aeruginosa |
| title_short | In vitro activity of hybrid lavender essential oils against multidrug resistant strains of Pseudomonas aeruginosa |
| title_sort | in vitro activity of hybrid lavender essential oils against multidrug resistant strains of pseudomonas aeruginosa |
| topic | Antimicrobials; Biopharmaceuticals; Cytotoxicity; Infection; Pseudomonads |
| url | https://jidc.org/index.php/journal/article/view/9920 |
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