THE EFFECTS OF ALPHA LIPOIC ACID ON LENS INJURY IN RATS ADMINISTERED WITH VALPROIC ACID
Objective: Valproic acid (2-propyl valeric acid; VPA) is an effective short-chained fatty acid which is used for the treatment of migraine and schizophrenia. Though it provides effective treatment, its side effects are associated with free radicals and in this way it affects many organs and tissues....
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Istanbul University Press
2022-10-01
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| Series: | İstanbul Tıp Fakültesi Dergisi |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/94B97F52E41C4456B6AD34BCC0EC1A64 |
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| author | Yeşim Öztaylan İsmet Burcu Türkyılmaz Refiye Yanardağ |
| author_facet | Yeşim Öztaylan İsmet Burcu Türkyılmaz Refiye Yanardağ |
| author_sort | Yeşim Öztaylan |
| collection | DOAJ |
| description | Objective: Valproic acid (2-propyl valeric acid; VPA) is an effective short-chained fatty acid which is used for the treatment of migraine and schizophrenia. Though it provides effective treatment, its side effects are associated with free radicals and in this way it affects many organs and tissues. Alpha lipoic acid (ALA) is known to be a powerful antioxidant. Material and Methods: The aim of this current study was to investigate the protection of ALA on VPA induced lens injury. Female rats were split into four groups as follows: 1st group, control animals (corn oil per day for 15 days); 2nd group, ALA administered group (50 mg per kg each day for 15 days); 3rd group, VPA administered group (500 mg per kg each day for 15 days) and 4th group, VPA and ALA administered group to which the same dose was given at the same time each day. On the 16th day, lens tissues were taken. Results: Lens glutathione levels and glutathione-S-transferase activities were decreased while lipid peroxidation and protein carbonyl levels, superoxide dismutase, glutathione peroxidase and reductase, aldose reductase and sorbitol dehydrogenase activities were elevated after VPA administration. ALA reversed these levels and activities in the VPA group. Conclusion: We can conclude that ALA used its antioxidant property and ameliorated VPA induced lens injury. |
| format | Article |
| id | doaj-art-afc8044e1beb40bab0cbf04847c33019 |
| institution | Kabale University |
| issn | 1305-6441 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | İstanbul Tıp Fakültesi Dergisi |
| spelling | doaj-art-afc8044e1beb40bab0cbf04847c330192025-08-20T03:52:47ZengIstanbul University Pressİstanbul Tıp Fakültesi Dergisi1305-64412022-10-0185455756310.26650/IUITFD.1073100123456THE EFFECTS OF ALPHA LIPOIC ACID ON LENS INJURY IN RATS ADMINISTERED WITH VALPROIC ACIDYeşim Öztaylan0https://orcid.org/0000-0002-2051-4098İsmet Burcu Türkyılmaz1https://orcid.org/0000-0003-2789-5943Refiye Yanardağ2https://orcid.org/0000-0003-4185-4363İstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, TurkiyeObjective: Valproic acid (2-propyl valeric acid; VPA) is an effective short-chained fatty acid which is used for the treatment of migraine and schizophrenia. Though it provides effective treatment, its side effects are associated with free radicals and in this way it affects many organs and tissues. Alpha lipoic acid (ALA) is known to be a powerful antioxidant. Material and Methods: The aim of this current study was to investigate the protection of ALA on VPA induced lens injury. Female rats were split into four groups as follows: 1st group, control animals (corn oil per day for 15 days); 2nd group, ALA administered group (50 mg per kg each day for 15 days); 3rd group, VPA administered group (500 mg per kg each day for 15 days) and 4th group, VPA and ALA administered group to which the same dose was given at the same time each day. On the 16th day, lens tissues were taken. Results: Lens glutathione levels and glutathione-S-transferase activities were decreased while lipid peroxidation and protein carbonyl levels, superoxide dismutase, glutathione peroxidase and reductase, aldose reductase and sorbitol dehydrogenase activities were elevated after VPA administration. ALA reversed these levels and activities in the VPA group. Conclusion: We can conclude that ALA used its antioxidant property and ameliorated VPA induced lens injury.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/94B97F52E41C4456B6AD34BCC0EC1A64valproic acidalpha lipoic acidlens tissueoxidative stress |
| spellingShingle | Yeşim Öztaylan İsmet Burcu Türkyılmaz Refiye Yanardağ THE EFFECTS OF ALPHA LIPOIC ACID ON LENS INJURY IN RATS ADMINISTERED WITH VALPROIC ACID İstanbul Tıp Fakültesi Dergisi valproic acid alpha lipoic acid lens tissue oxidative stress |
| title | THE EFFECTS OF ALPHA LIPOIC ACID ON LENS INJURY IN RATS ADMINISTERED WITH VALPROIC ACID |
| title_full | THE EFFECTS OF ALPHA LIPOIC ACID ON LENS INJURY IN RATS ADMINISTERED WITH VALPROIC ACID |
| title_fullStr | THE EFFECTS OF ALPHA LIPOIC ACID ON LENS INJURY IN RATS ADMINISTERED WITH VALPROIC ACID |
| title_full_unstemmed | THE EFFECTS OF ALPHA LIPOIC ACID ON LENS INJURY IN RATS ADMINISTERED WITH VALPROIC ACID |
| title_short | THE EFFECTS OF ALPHA LIPOIC ACID ON LENS INJURY IN RATS ADMINISTERED WITH VALPROIC ACID |
| title_sort | effects of alpha lipoic acid on lens injury in rats administered with valproic acid |
| topic | valproic acid alpha lipoic acid lens tissue oxidative stress |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/94B97F52E41C4456B6AD34BCC0EC1A64 |
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