One gene, many phenotypes: the role of KIF5A in neurodegenerative and neurodevelopmental diseases

One gene, many phenotypes: the role of KIF5A in neurodegenerative and neurodevelopmental diseases

Abstract Kinesin family member 5 A (KIF5A) is a neuron-specific molecular motor involved in anterograde transport. KIF5A mediates a wide range of trafficking processes that are only partially shared with the other members of the KIF5 family. Since 2002, several disease-causing mutations have been fo...

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Main Authors: Marta Cozzi, Barbara Tedesco, Veronica Ferrari, Marta Chierichetti, Paola Pramaggiore, Laura Cornaggia, Rocio Magdalena, Maria Brodnanova, Ali Mohamed, Carmelo Milioto, Margherita Piccolella, Mariarita Galbiati, Paola Rusmini, Valeria Crippa, Cinzia Gellera, Stefania Magri, Franco Taroni, Riccardo Cristofani, Angelo Poletti
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cell Communication and Signaling
Subjects:
KIF5A
Hereditary spastic paraplegia
Charcot-Marie-Tooth disease
Amyotrophic lateral sclerosis
Neonatal intractable myoclonus
Online Access:https://doi.org/10.1186/s12964-025-02277-x
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