Unmasking the relationship between CGRP and glutamate: from peripheral excitation to central sensitization in migraine

Unmasking the relationship between CGRP and glutamate: from peripheral excitation to central sensitization in migraine

Abstract The exact mechanisms that trigger the activation of the trigeminovascular system in migraine remain unclear. The involvement of calcitonin gene-related peptide (CGRP) in migraine is well-documented, and treatments aimed at blocking CGRP activity have proven successful in reducing migraine a...

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Bibliographic Details
Main Authors: Fahimeh Martami, Kathleen F. Holton
Format: Article
Language:English
Published: BMC 2025-05-01
Series:The Journal of Headache and Pain
Subjects:
Migraine
CGRP
Excitotoxicity
Glutamate
NMDA
Online Access:https://doi.org/10.1186/s10194-025-02043-x
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