Early atypical MRI findings in a pediatric patient with Neuro-Behçet’s disease
Abstract Behçet’s disease (BD) is a multi-system recurrent inflammatory disease. Neuro-Behçet’s disease (NBD), as a severe and rare manifestation of BD, is frequently misdiagnosed in its early stages. Pediatric NBD poses diagnostic challenges due to its insidious onset, highlighting the critical rol...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-04-01
|
| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-025-04150-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849734761004662784 |
|---|---|
| author | Sihan Wang Qi Shan Jiawen Tang Fan Xia Jinyang Zhao Xiaohong Lyu |
| author_facet | Sihan Wang Qi Shan Jiawen Tang Fan Xia Jinyang Zhao Xiaohong Lyu |
| author_sort | Sihan Wang |
| collection | DOAJ |
| description | Abstract Behçet’s disease (BD) is a multi-system recurrent inflammatory disease. Neuro-Behçet’s disease (NBD), as a severe and rare manifestation of BD, is frequently misdiagnosed in its early stages. Pediatric NBD poses diagnostic challenges due to its insidious onset, highlighting the critical role of neuroimaging. This report describes a pediatric patient with atypical early clinical manifestations and magnetic resonance imaging (MRI) findings. The patient initially presented without mucocutaneous lesions despite persistently elevated inflammatory markers. MRI revealed prolonged T1/T2 signals in the posterior horns of the lateral ventricles. During years of follow-up, the patient gradually developed characteristic BD manifestations while MRI showed progressive intracranial lesions, eventually presenting typical NBD imaging features concurrently with cerebral venous thrombosis. This atypical case highlights the necessity of early multimodal MRI and close clinical monitoring of focal lesions in the posterior horns of the lateral ventricles. When infectious causes are excluded, NBD should be considered. The rarity of this case improves clinicians’ ability to diagnose early NBD through MRI interpretation. Clinical trial This case report did not involve a clinical trial. |
| format | Article |
| id | doaj-art-afbe4f66bf50405daf7435f456be4d1f |
| institution | DOAJ |
| issn | 1471-2377 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj-art-afbe4f66bf50405daf7435f456be4d1f2025-08-20T03:07:43ZengBMCBMC Neurology1471-23772025-04-012511510.1186/s12883-025-04150-3Early atypical MRI findings in a pediatric patient with Neuro-Behçet’s diseaseSihan Wang0Qi Shan1Jiawen Tang2Fan Xia3Jinyang Zhao4Xiaohong Lyu5Radiology department, First Affiliated Hospital of Jinzhou Medical UniversityRadiology department, First Affiliated Hospital of Jinzhou Medical UniversityRadiology department, First Affiliated Hospital of Jinzhou Medical UniversityRadiology department, First Affiliated Hospital of Jinzhou Medical UniversityRadiology department, First Affiliated Hospital of Jinzhou Medical UniversityRadiology department, First Affiliated Hospital of Jinzhou Medical UniversityAbstract Behçet’s disease (BD) is a multi-system recurrent inflammatory disease. Neuro-Behçet’s disease (NBD), as a severe and rare manifestation of BD, is frequently misdiagnosed in its early stages. Pediatric NBD poses diagnostic challenges due to its insidious onset, highlighting the critical role of neuroimaging. This report describes a pediatric patient with atypical early clinical manifestations and magnetic resonance imaging (MRI) findings. The patient initially presented without mucocutaneous lesions despite persistently elevated inflammatory markers. MRI revealed prolonged T1/T2 signals in the posterior horns of the lateral ventricles. During years of follow-up, the patient gradually developed characteristic BD manifestations while MRI showed progressive intracranial lesions, eventually presenting typical NBD imaging features concurrently with cerebral venous thrombosis. This atypical case highlights the necessity of early multimodal MRI and close clinical monitoring of focal lesions in the posterior horns of the lateral ventricles. When infectious causes are excluded, NBD should be considered. The rarity of this case improves clinicians’ ability to diagnose early NBD through MRI interpretation. Clinical trial This case report did not involve a clinical trial.https://doi.org/10.1186/s12883-025-04150-3Behçet diseaseNeuro-Behçet's diseaseChildrenMRI |
| spellingShingle | Sihan Wang Qi Shan Jiawen Tang Fan Xia Jinyang Zhao Xiaohong Lyu Early atypical MRI findings in a pediatric patient with Neuro-Behçet’s disease BMC Neurology Behçet disease Neuro-Behçet's disease Children MRI |
| title | Early atypical MRI findings in a pediatric patient with Neuro-Behçet’s disease |
| title_full | Early atypical MRI findings in a pediatric patient with Neuro-Behçet’s disease |
| title_fullStr | Early atypical MRI findings in a pediatric patient with Neuro-Behçet’s disease |
| title_full_unstemmed | Early atypical MRI findings in a pediatric patient with Neuro-Behçet’s disease |
| title_short | Early atypical MRI findings in a pediatric patient with Neuro-Behçet’s disease |
| title_sort | early atypical mri findings in a pediatric patient with neuro behcet s disease |
| topic | Behçet disease Neuro-Behçet's disease Children MRI |
| url | https://doi.org/10.1186/s12883-025-04150-3 |
| work_keys_str_mv | AT sihanwang earlyatypicalmrifindingsinapediatricpatientwithneurobehcetsdisease AT qishan earlyatypicalmrifindingsinapediatricpatientwithneurobehcetsdisease AT jiawentang earlyatypicalmrifindingsinapediatricpatientwithneurobehcetsdisease AT fanxia earlyatypicalmrifindingsinapediatricpatientwithneurobehcetsdisease AT jinyangzhao earlyatypicalmrifindingsinapediatricpatientwithneurobehcetsdisease AT xiaohonglyu earlyatypicalmrifindingsinapediatricpatientwithneurobehcetsdisease |