PrediQt-Cx: post treatment health related quality of life prediction model for cervical cancer patients.
<h4>Background</h4>Cervical cancer is the third largest cause of cancer mortality in India. The objectives of the study were to compare the pre and the post treatment quality of life in cervical cancer patients and to develop a prediction model to provide an insight into the possibilitie...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089851&type=printable |
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| author | Satwant Kumar Madhu Lata Rana Khushboo Verma Narayanjeet Singh Anil Kumar Sharma Arun Kumar Maria Gobind Singh Dhaliwal Harkiran Kaur Khaira Sunil Saini |
| author_facet | Satwant Kumar Madhu Lata Rana Khushboo Verma Narayanjeet Singh Anil Kumar Sharma Arun Kumar Maria Gobind Singh Dhaliwal Harkiran Kaur Khaira Sunil Saini |
| author_sort | Satwant Kumar |
| collection | DOAJ |
| description | <h4>Background</h4>Cervical cancer is the third largest cause of cancer mortality in India. The objectives of the study were to compare the pre and the post treatment quality of life in cervical cancer patients and to develop a prediction model to provide an insight into the possibilities in the treatment modules.<h4>Methodology/principal findings</h4>A total of 198 patients were assessed with two structured questionnaires of Health Related Quality of Life (The European Organisation for Research and Treatment of Cancer, EORTC QLQ C-30 and CX-24). The baseline observations were recorded when the patients first reported (T1) and second evaluation was done at 6 months post treatment (T2). The mean age of detection was 50.9 years with the literacy level being non-educated or less than high school. Majority of them were married/cohabiting 179 (90.4%). On histopathological examination (HPE) squamous cell carcinoma was found to be the most common cell type carcinoma 147 (74.2%) followed by Adenocarcinoma 31 (15.7%). Radical hysterectomy was the most common treatment modality 76 (38.4%), followed by Wertheims Hysterectomy 46 (23.2%) and Radiochemotherapy 59 (29.8%). The mean score of global health of cervical cancer patients post treatment was 77.90, which was significantly higher than the pre - treatment score (54.32). Mean "symptoms score" post treatment was 21.69 with an aggravation of 7.32 compared to pre treatment scores. Patients experienced substantial decrease in sexual activity post treatment.<h4>Conclusions/significance</h4>The prediction model(PrediQt-Cx), based on Support Vector Machine(SVM) for predicting post treatment HRQoL in cervical cancer patients was developed and internally cross validated. After external validation PrediQt-Cx can be easily employed to support decision making by clinicians and patients from north India region, through openly made available for access at http://prediqt.org. |
| format | Article |
| id | doaj-art-afbcc9859d7b4b7eb745ae9a29af0239 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-afbcc9859d7b4b7eb745ae9a29af02392025-08-20T03:11:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8985110.1371/journal.pone.0089851PrediQt-Cx: post treatment health related quality of life prediction model for cervical cancer patients.Satwant KumarMadhu Lata RanaKhushboo VermaNarayanjeet SinghAnil Kumar SharmaArun Kumar MariaGobind Singh DhaliwalHarkiran Kaur KhairaSunil Saini<h4>Background</h4>Cervical cancer is the third largest cause of cancer mortality in India. The objectives of the study were to compare the pre and the post treatment quality of life in cervical cancer patients and to develop a prediction model to provide an insight into the possibilities in the treatment modules.<h4>Methodology/principal findings</h4>A total of 198 patients were assessed with two structured questionnaires of Health Related Quality of Life (The European Organisation for Research and Treatment of Cancer, EORTC QLQ C-30 and CX-24). The baseline observations were recorded when the patients first reported (T1) and second evaluation was done at 6 months post treatment (T2). The mean age of detection was 50.9 years with the literacy level being non-educated or less than high school. Majority of them were married/cohabiting 179 (90.4%). On histopathological examination (HPE) squamous cell carcinoma was found to be the most common cell type carcinoma 147 (74.2%) followed by Adenocarcinoma 31 (15.7%). Radical hysterectomy was the most common treatment modality 76 (38.4%), followed by Wertheims Hysterectomy 46 (23.2%) and Radiochemotherapy 59 (29.8%). The mean score of global health of cervical cancer patients post treatment was 77.90, which was significantly higher than the pre - treatment score (54.32). Mean "symptoms score" post treatment was 21.69 with an aggravation of 7.32 compared to pre treatment scores. Patients experienced substantial decrease in sexual activity post treatment.<h4>Conclusions/significance</h4>The prediction model(PrediQt-Cx), based on Support Vector Machine(SVM) for predicting post treatment HRQoL in cervical cancer patients was developed and internally cross validated. After external validation PrediQt-Cx can be easily employed to support decision making by clinicians and patients from north India region, through openly made available for access at http://prediqt.org.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089851&type=printable |
| spellingShingle | Satwant Kumar Madhu Lata Rana Khushboo Verma Narayanjeet Singh Anil Kumar Sharma Arun Kumar Maria Gobind Singh Dhaliwal Harkiran Kaur Khaira Sunil Saini PrediQt-Cx: post treatment health related quality of life prediction model for cervical cancer patients. PLoS ONE |
| title | PrediQt-Cx: post treatment health related quality of life prediction model for cervical cancer patients. |
| title_full | PrediQt-Cx: post treatment health related quality of life prediction model for cervical cancer patients. |
| title_fullStr | PrediQt-Cx: post treatment health related quality of life prediction model for cervical cancer patients. |
| title_full_unstemmed | PrediQt-Cx: post treatment health related quality of life prediction model for cervical cancer patients. |
| title_short | PrediQt-Cx: post treatment health related quality of life prediction model for cervical cancer patients. |
| title_sort | prediqt cx post treatment health related quality of life prediction model for cervical cancer patients |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089851&type=printable |
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