Can Dermoscopy Be a Useful Follow-Up Tool in Patients with Discoid Lupus Treated with Anifrolumab?
This report discusses a female patient with longstanding discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE), refractory to multiple immunosuppressive and biologic treatments. Upon presenting with infiltrated, hypertrophic plaques in facial and décolletage regions, she was start...
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MDPI AG
2025-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/5/522 |
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| author | Francesca Ambrogio Caterina Foti Silvia Noviello Gerardo Cazzato Alexandre Raphael Meduri Carolina Marasco Angelo Vacca Benedetta Tirone |
| author_facet | Francesca Ambrogio Caterina Foti Silvia Noviello Gerardo Cazzato Alexandre Raphael Meduri Carolina Marasco Angelo Vacca Benedetta Tirone |
| author_sort | Francesca Ambrogio |
| collection | DOAJ |
| description | This report discusses a female patient with longstanding discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE), refractory to multiple immunosuppressive and biologic treatments. Upon presenting with infiltrated, hypertrophic plaques in facial and décolletage regions, she was started on anifrolumab therapy after the histopathological confirmation of DLE. Following three infusions, significant clinical and dermoscopic improvements were observed, including the resolution of plaques and regression of scarring areas. This case highlights anifrolumab’s efficacy in severe lupus skin manifestations, emphasizing its potential to induce dermoscopic and histological remission. Additionally, it suggests that dermoscopy could be a valuable tool for monitoring therapeutic responses in DLE and cutaneous lupus erythematosus, warranting further investigation. |
| format | Article |
| id | doaj-art-afb85bfeaa744db0b44544a0e831caff |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-afb85bfeaa744db0b44544a0e831caff2025-08-20T02:05:17ZengMDPI AGDiagnostics2075-44182025-02-0115552210.3390/diagnostics15050522Can Dermoscopy Be a Useful Follow-Up Tool in Patients with Discoid Lupus Treated with Anifrolumab?Francesca Ambrogio0Caterina Foti1Silvia Noviello2Gerardo Cazzato3Alexandre Raphael Meduri4Carolina Marasco5Angelo Vacca6Benedetta Tirone7Section of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalyInternal Medicine ‘Guido Baccelli’, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari ‘Aldo Moro’, AUOC Policlinico di Bari, 70124 Bari, ItalySection of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70121 Bari, ItalySection of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalyInternal Medicine ‘Guido Baccelli’, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari ‘Aldo Moro’, AUOC Policlinico di Bari, 70124 Bari, ItalyInternal Medicine ‘Guido Baccelli’, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari ‘Aldo Moro’, AUOC Policlinico di Bari, 70124 Bari, ItalySection of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, ItalyThis report discusses a female patient with longstanding discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE), refractory to multiple immunosuppressive and biologic treatments. Upon presenting with infiltrated, hypertrophic plaques in facial and décolletage regions, she was started on anifrolumab therapy after the histopathological confirmation of DLE. Following three infusions, significant clinical and dermoscopic improvements were observed, including the resolution of plaques and regression of scarring areas. This case highlights anifrolumab’s efficacy in severe lupus skin manifestations, emphasizing its potential to induce dermoscopic and histological remission. Additionally, it suggests that dermoscopy could be a valuable tool for monitoring therapeutic responses in DLE and cutaneous lupus erythematosus, warranting further investigation.https://www.mdpi.com/2075-4418/15/5/522anifrolumabsystemic lupus erythematosusDLEdermoscopy |
| spellingShingle | Francesca Ambrogio Caterina Foti Silvia Noviello Gerardo Cazzato Alexandre Raphael Meduri Carolina Marasco Angelo Vacca Benedetta Tirone Can Dermoscopy Be a Useful Follow-Up Tool in Patients with Discoid Lupus Treated with Anifrolumab? Diagnostics anifrolumab systemic lupus erythematosus DLE dermoscopy |
| title | Can Dermoscopy Be a Useful Follow-Up Tool in Patients with Discoid Lupus Treated with Anifrolumab? |
| title_full | Can Dermoscopy Be a Useful Follow-Up Tool in Patients with Discoid Lupus Treated with Anifrolumab? |
| title_fullStr | Can Dermoscopy Be a Useful Follow-Up Tool in Patients with Discoid Lupus Treated with Anifrolumab? |
| title_full_unstemmed | Can Dermoscopy Be a Useful Follow-Up Tool in Patients with Discoid Lupus Treated with Anifrolumab? |
| title_short | Can Dermoscopy Be a Useful Follow-Up Tool in Patients with Discoid Lupus Treated with Anifrolumab? |
| title_sort | can dermoscopy be a useful follow up tool in patients with discoid lupus treated with anifrolumab |
| topic | anifrolumab systemic lupus erythematosus DLE dermoscopy |
| url | https://www.mdpi.com/2075-4418/15/5/522 |
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