Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn’s disease
Despite the increasing incidence of Crohn’s disease (CD), its early immune disturbances have not all been described yet. We analysed single-cell RNASeq data from peripheral blood mononuclear cells of patients with incidentally-diagnosed CD, and compared their gene expression profile to healthy indiv...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1539830/full |
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| author | Dimitrios Kioroglou Leire Egia-Mendikute Asis Palazon Asis Palazon Manuel Barreiro-de Acosta Iago Rodríguez-Lago Iago Rodríguez-Lago Urko M. Marigorta Urko M. Marigorta |
| author_facet | Dimitrios Kioroglou Leire Egia-Mendikute Asis Palazon Asis Palazon Manuel Barreiro-de Acosta Iago Rodríguez-Lago Iago Rodríguez-Lago Urko M. Marigorta Urko M. Marigorta |
| author_sort | Dimitrios Kioroglou |
| collection | DOAJ |
| description | Despite the increasing incidence of Crohn’s disease (CD), its early immune disturbances have not all been described yet. We analysed single-cell RNASeq data from peripheral blood mononuclear cells of patients with incidentally-diagnosed CD, and compared their gene expression profile to healthy individuals. The main aim of our study was to perform an exploratory analysis of how the subclinical inflammatory process is modifying the individual’s immunologic environment while the patient is still in the preclinical period. |
| format | Article |
| id | doaj-art-afb4fc33d86d4b2e9c286a099cdb7563 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-afb4fc33d86d4b2e9c286a099cdb75632025-08-20T03:13:11ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15398301539830Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn’s diseaseDimitrios Kioroglou0Leire Egia-Mendikute1Asis Palazon2Asis Palazon3Manuel Barreiro-de Acosta4Iago Rodríguez-Lago5Iago Rodríguez-Lago6Urko M. Marigorta7Urko M. Marigorta8Integrative Genomics Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, SpainCancer Immunology and Immunotherapy Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, SpainCancer Immunology and Immunotherapy Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, SpainIKERBASQUE, Basque Foundation for Sciences, Bilbao, SpainGastroenterology Department, Hospital Clínico Universitario de Santiago, Santiago de Compostela, SpainGastroenterology Department, Hospital Universitario de Galdakao, Biobizkaia Health Research Institute, Galdakao, SpainDepartment of Medicine, Faculty of Health Sciences, University of Deusto, Bilbao, SpainIntegrative Genomics Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, SpainIKERBASQUE, Basque Foundation for Sciences, Bilbao, SpainDespite the increasing incidence of Crohn’s disease (CD), its early immune disturbances have not all been described yet. We analysed single-cell RNASeq data from peripheral blood mononuclear cells of patients with incidentally-diagnosed CD, and compared their gene expression profile to healthy individuals. The main aim of our study was to perform an exploratory analysis of how the subclinical inflammatory process is modifying the individual’s immunologic environment while the patient is still in the preclinical period.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1539830/fullCrohn’s diseasescRNAseqPBMCpreclinicalIBD |
| spellingShingle | Dimitrios Kioroglou Leire Egia-Mendikute Asis Palazon Asis Palazon Manuel Barreiro-de Acosta Iago Rodríguez-Lago Iago Rodríguez-Lago Urko M. Marigorta Urko M. Marigorta Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn’s disease Frontiers in Immunology Crohn’s disease scRNAseq PBMC preclinical IBD |
| title | Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn’s disease |
| title_full | Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn’s disease |
| title_fullStr | Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn’s disease |
| title_full_unstemmed | Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn’s disease |
| title_short | Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn’s disease |
| title_sort | single cell analysis reveals significant transcriptomic alterations in preclinical crohn s disease |
| topic | Crohn’s disease scRNAseq PBMC preclinical IBD |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1539830/full |
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