Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn’s disease

Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn’s disease

Despite the increasing incidence of Crohn’s disease (CD), its early immune disturbances have not all been described yet. We analysed single-cell RNASeq data from peripheral blood mononuclear cells of patients with incidentally-diagnosed CD, and compared their gene expression profile to healthy indiv...

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Bibliographic Details
Main Authors: Dimitrios Kioroglou, Leire Egia-Mendikute, Asis Palazon, Manuel Barreiro-de Acosta, Iago Rodríguez-Lago, Urko M. Marigorta
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
Crohn’s disease
scRNAseq
PBMC
preclinical
IBD
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1539830/full
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Summary:Despite the increasing incidence of Crohn’s disease (CD), its early immune disturbances have not all been described yet. We analysed single-cell RNASeq data from peripheral blood mononuclear cells of patients with incidentally-diagnosed CD, and compared their gene expression profile to healthy individuals. The main aim of our study was to perform an exploratory analysis of how the subclinical inflammatory process is modifying the individual’s immunologic environment while the patient is still in the preclinical period.
ISSN:1664-3224

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