The role and therapeutic potential of mitophagy in major depressive disorder
Major depressive disorder, also known as MDD, affects more than 264 million people globally, making it a prevalent and critical health challenge. Traditional treatments show limited efficacy in many patients. Therefore, exploring new treatment methods is particularly crucial. Mitophagy, as a regulat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1564276/full |
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| author | Xin-Nuan Shi Chen-Yue Liu Lin Li Ming-Li Yao Zhen Zhong You-Ming Jiang |
| author_facet | Xin-Nuan Shi Chen-Yue Liu Lin Li Ming-Li Yao Zhen Zhong You-Ming Jiang |
| author_sort | Xin-Nuan Shi |
| collection | DOAJ |
| description | Major depressive disorder, also known as MDD, affects more than 264 million people globally, making it a prevalent and critical health challenge. Traditional treatments show limited efficacy in many patients. Therefore, exploring new treatment methods is particularly crucial. Mitophagy, as a regulatory process, can help understand and treat MDD. This paper focuses on the molecular mechanisms of mitophagy, starting from proteins and related pathways, and its role in MDD. The study also explores the associations between mitophagy and neuroinflammation, oxidative stress, neurotransmitter synthesis, and neuroplasticity in MDD and discusses the progress of clinical research on the role of mitophagy in MDD. In addition, the article describes the current pharmaceutical and non-pharmaceutical interventions that can regulate mitophagy in MDD and unravels the potential and challenges of these therapeutic strategies in clinical settings. This article offers a deeper insight into the pathogenesis of MDD and offers a scientific basis for the development of new treatment strategies. |
| format | Article |
| id | doaj-art-afb343abc06349338d84c38836df54dd |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-afb343abc06349338d84c38836df54dd2025-08-20T03:40:57ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-03-011610.3389/fphar.2025.15642761564276The role and therapeutic potential of mitophagy in major depressive disorderXin-Nuan Shi0Chen-Yue Liu1Lin Li2Ming-Li Yao3Zhen Zhong4You-Ming Jiang5School of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaTraditional Chinese Medicine School, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaMajor depressive disorder, also known as MDD, affects more than 264 million people globally, making it a prevalent and critical health challenge. Traditional treatments show limited efficacy in many patients. Therefore, exploring new treatment methods is particularly crucial. Mitophagy, as a regulatory process, can help understand and treat MDD. This paper focuses on the molecular mechanisms of mitophagy, starting from proteins and related pathways, and its role in MDD. The study also explores the associations between mitophagy and neuroinflammation, oxidative stress, neurotransmitter synthesis, and neuroplasticity in MDD and discusses the progress of clinical research on the role of mitophagy in MDD. In addition, the article describes the current pharmaceutical and non-pharmaceutical interventions that can regulate mitophagy in MDD and unravels the potential and challenges of these therapeutic strategies in clinical settings. This article offers a deeper insight into the pathogenesis of MDD and offers a scientific basis for the development of new treatment strategies.https://www.frontiersin.org/articles/10.3389/fphar.2025.1564276/fullmajor depressive disordermitophagymitophagy-related proteinsmitophagy-related pathwaystherapeutic potential |
| spellingShingle | Xin-Nuan Shi Chen-Yue Liu Lin Li Ming-Li Yao Zhen Zhong You-Ming Jiang The role and therapeutic potential of mitophagy in major depressive disorder Frontiers in Pharmacology major depressive disorder mitophagy mitophagy-related proteins mitophagy-related pathways therapeutic potential |
| title | The role and therapeutic potential of mitophagy in major depressive disorder |
| title_full | The role and therapeutic potential of mitophagy in major depressive disorder |
| title_fullStr | The role and therapeutic potential of mitophagy in major depressive disorder |
| title_full_unstemmed | The role and therapeutic potential of mitophagy in major depressive disorder |
| title_short | The role and therapeutic potential of mitophagy in major depressive disorder |
| title_sort | role and therapeutic potential of mitophagy in major depressive disorder |
| topic | major depressive disorder mitophagy mitophagy-related proteins mitophagy-related pathways therapeutic potential |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1564276/full |
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