Pathway activation model for personalized prediction of drug synergy

Pathway activation model for personalized prediction of drug synergy

Targeted monotherapies for cancer often fail due to inherent or acquired drug resistance. By aiming at multiple targets simultaneously, drug combinations can produce synergistic interactions that increase drug effectiveness and reduce resistance. Computational models based on the integration of omic...

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Main Authors: Quang Thinh Trac, Yue Huang, Tom Erkers, Päivi Östling, Anna Bohlin, Albin Osterroos, Mattias Vesterlund, Rozbeh Jafari, Ioannis Siavelis, Helena Backvall, Santeri Kiviluoto, Lukas Orre, Mattias Rantalainen, Janne Lehtiö, Soren Lehmann, Olli Kallioniemi, Yudi Pawitan, Trung Nghia Vu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-06-01
Series:eLife
Subjects:
drug synergy
prediction model
pathway activation score
Online Access:https://elifesciences.org/articles/100071
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