Myricetin Potentiates Antibiotics Against Resistant <i>Pseudomonas aeruginosa</i> by Disrupting Biofilm Formation and Inhibiting Motility Through FimX-Mediated c-di-GMP Signaling Interference

Myricetin Potentiates Antibiotics Against Resistant <i>Pseudomonas aeruginosa</i> by Disrupting Biofilm Formation and Inhibiting Motility Through FimX-Mediated c-di-GMP Signaling Interference

<i>Pseudomonas aeruginosa</i> biofilm formation is critical to antibiotic resistance and persistence. Targeting cyclic di-GMP (c-di-GMP) signaling, a master biofilm formation and virulence regulator, presents a promising strategy to combat resistant bacterial infections. Myricetin, a nat...

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Bibliographic Details
Main Authors: Derong Zeng, Fangfang Jiao, Yuqi Yang, Shuai Dou, Jiahua Yu, Xiang Yu, Yongqiang Zhou, Juan Xue, Xue Li, Hongliang Duan, Yan Zhang, Jingjing Guo, Wude Yang
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biology
Subjects:
<i>Pseudomonas aeruginosa</i>
antibiotic resistance
biofilm
c-di-GMP
FimX
myricetin
Online Access:https://www.mdpi.com/2079-7737/14/7/859
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