A Shared Path: Co-occurrence and Clinical Implications of Celiac Disease and Type 1 Diabetes Mellitus
Introduction: Celiac disease (CeD) and Type 1 diabetes mellitus (T1DM) are autoimmune diseases that sometimes co-occur in genetically predisposed people. Both diseases share common genetic factors, such as human leukocyte antigens: HLA-DQ2 and HLA-DQ8. Apart from that, they share environmental...
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| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-01-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57099 |
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| author | Wojciech Florczak Joanna Śnieżna Jakub Dziewic Karol Dzwonnik Wiktoria Domino Urszula Zelik Gabriela Trestka Maria Przygoda Jagienka Włodyka Kamila Stępień Sabina Adamczyk |
| author_facet | Wojciech Florczak Joanna Śnieżna Jakub Dziewic Karol Dzwonnik Wiktoria Domino Urszula Zelik Gabriela Trestka Maria Przygoda Jagienka Włodyka Kamila Stępień Sabina Adamczyk |
| author_sort | Wojciech Florczak |
| collection | DOAJ |
| description |
Introduction:
Celiac disease (CeD) and Type 1 diabetes mellitus (T1DM) are autoimmune diseases that sometimes co-occur in genetically predisposed people. Both diseases share common genetic factors, such as human leukocyte antigens: HLA-DQ2 and HLA-DQ8. Apart from that, they share environmental factors such as gluten exposure, viral infections, and alterations in gut microbiota composition. CeD is a gluten-induced disease resulting in inflammation and impaired absorption of the nutrients, leading to malnutrition. In T1DM, β-cells in the pancreatic tissue are destroyed during the T-cell mediated reaction, which leads to impaired insulin production and development of insulin deficiency which leads to hyperglycemia and chronic complications.
Materials and methods:
This study is based on a review of multiple articles and prospective studies we managed to find online in the PubMed database.
Aim of the study:
The aim of the study is to investigate the clinical implications of T1DM and CeD, focusing on the importance of early screening for CeD in patients with T1DM and evaluate the challenges in the management of both diseases simultaneously. Additionally, the study highlights the potential benefits of a personalized approach to treatment.
Conclusions:
The co-occurrence of CeD and T1DM is common and it’s determined by shared genetic, immune, and environmental factors. Early screening and diagnosis are very important regarding the management strategies for these conditions. Gluten free diet (GFD) is the main treatment for CeD, but its adherence may be challenging, especially in T1DM patients who already face many restrictions on a daily basis. Personalized treatment approaches seem to be essential for simultaneously managing and optimizing CeD and T1DM. However, the lower compliance to GFD among T1DM patients suggests the need for further research to provide support for long-term management of both T1DM and CeD.
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| format | Article |
| id | doaj-art-afad3c5a0aff4523a8939e46df76b538 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-afad3c5a0aff4523a8939e46df76b5382025-01-28T08:25:08ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-01-013710.12775/QS.2024.37.57099A Shared Path: Co-occurrence and Clinical Implications of Celiac Disease and Type 1 Diabetes MellitusWojciech Florczak0https://orcid.org/0009-0006-8003-0999Joanna Śnieżna1https://orcid.org/0009-0006-2713-0835Jakub Dziewic2https://orcid.org/0009-0008-4338-4573Karol Dzwonnik3https://orcid.org/0009-0007-1366-3945Wiktoria Domino4https://orcid.org/0009-0005-0034-7463Urszula Zelik5https://orcid.org/0009-0009-3369-7936Gabriela Trestka6https://orcid.org/0009-0009-9504-8923Maria Przygoda7https://orcid.org/0000-0002-6409-7265Jagienka Włodyka8https://orcid.org/0009-0000-7243-7023Kamila Stępień9https://orcid.org/0009-0000-3579-9308Sabina Adamczyk10https://orcid.org/0009-0003-9671-6619Medical University of LublinMedical University of LublinMedical University of LublinMedical University of LublinClinical Provincial Hospital No. 2 in Rzeszów, Poland Lwowska 60, 35-501 Rzeszów, PolandUniversity Teaching Hospital them F. Chopin in Rzeszów, Poland Fryderyka Szopena 2, 35-055 Rzeszów, PolandClinical Provincial Hospital No. 2 in Rzeszów, Poland Lwowska 60, 35-501 Rzeszów, PolandSpecialist Hospital named after Stefan Żeromski, Independent Public Healthcare Facility (SP ZOZ), in KrakówUniversity Teaching Hospital them F. Chopin in Rzeszów, Poland Fryderyka Szopena 2, 35-055 Rzeszów, PolandIndependent Public Health Care Facility of the Ministry of Internal Affairs and Administration in Kielce, Poland Wojska Polskiego 51, 25-375 Kielce, PolandIndependent Public Healthcare Facility of the Ministry of Internal Affairs and Administration in Opole, Poland Introduction: Celiac disease (CeD) and Type 1 diabetes mellitus (T1DM) are autoimmune diseases that sometimes co-occur in genetically predisposed people. Both diseases share common genetic factors, such as human leukocyte antigens: HLA-DQ2 and HLA-DQ8. Apart from that, they share environmental factors such as gluten exposure, viral infections, and alterations in gut microbiota composition. CeD is a gluten-induced disease resulting in inflammation and impaired absorption of the nutrients, leading to malnutrition. In T1DM, β-cells in the pancreatic tissue are destroyed during the T-cell mediated reaction, which leads to impaired insulin production and development of insulin deficiency which leads to hyperglycemia and chronic complications. Materials and methods: This study is based on a review of multiple articles and prospective studies we managed to find online in the PubMed database. Aim of the study: The aim of the study is to investigate the clinical implications of T1DM and CeD, focusing on the importance of early screening for CeD in patients with T1DM and evaluate the challenges in the management of both diseases simultaneously. Additionally, the study highlights the potential benefits of a personalized approach to treatment. Conclusions: The co-occurrence of CeD and T1DM is common and it’s determined by shared genetic, immune, and environmental factors. Early screening and diagnosis are very important regarding the management strategies for these conditions. Gluten free diet (GFD) is the main treatment for CeD, but its adherence may be challenging, especially in T1DM patients who already face many restrictions on a daily basis. Personalized treatment approaches seem to be essential for simultaneously managing and optimizing CeD and T1DM. However, the lower compliance to GFD among T1DM patients suggests the need for further research to provide support for long-term management of both T1DM and CeD. https://apcz.umk.pl/QS/article/view/57099celiacCeDT1DMdiabetesgluten |
| spellingShingle | Wojciech Florczak Joanna Śnieżna Jakub Dziewic Karol Dzwonnik Wiktoria Domino Urszula Zelik Gabriela Trestka Maria Przygoda Jagienka Włodyka Kamila Stępień Sabina Adamczyk A Shared Path: Co-occurrence and Clinical Implications of Celiac Disease and Type 1 Diabetes Mellitus Quality in Sport celiac CeD T1DM diabetes gluten |
| title | A Shared Path: Co-occurrence and Clinical Implications of Celiac Disease and Type 1 Diabetes Mellitus |
| title_full | A Shared Path: Co-occurrence and Clinical Implications of Celiac Disease and Type 1 Diabetes Mellitus |
| title_fullStr | A Shared Path: Co-occurrence and Clinical Implications of Celiac Disease and Type 1 Diabetes Mellitus |
| title_full_unstemmed | A Shared Path: Co-occurrence and Clinical Implications of Celiac Disease and Type 1 Diabetes Mellitus |
| title_short | A Shared Path: Co-occurrence and Clinical Implications of Celiac Disease and Type 1 Diabetes Mellitus |
| title_sort | shared path co occurrence and clinical implications of celiac disease and type 1 diabetes mellitus |
| topic | celiac CeD T1DM diabetes gluten |
| url | https://apcz.umk.pl/QS/article/view/57099 |
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