Spermidine cures yeast of prions
Prions are self-perpetuating amyloid protein aggregates which underlie various neurodegenerative diseases in mammals. The molecular basis underlying their conversion from a normally soluble protein into the prion form remains largely unknown. Studies aimed at uncovering these mechanism(s) are theref...
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Shared Science Publishers OG
2015-12-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/spermidine-cures-yeast-of-prions/ |
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| author | Shaun H. Speldewinde Chris M. Grant |
| author_facet | Shaun H. Speldewinde Chris M. Grant |
| author_sort | Shaun H. Speldewinde |
| collection | DOAJ |
| description | Prions are self-perpetuating amyloid protein aggregates which underlie various neurodegenerative diseases in mammals. The molecular basis underlying their conversion from a normally soluble protein into the prion form remains largely unknown. Studies aimed at uncovering these mechanism(s) are therefore essential if we are to develop effective therapeutic strategies to counteract these disease-causing entities. Autophagy is a cellular degradation system which has predominantly been considered as a non-selective bulk degradation process which recycles macromolecules in response to starvation conditions. We now know that autophagy also serves as a protein quality control mechanism which selectively degrades protein aggregates and damaged organelles. These are commonly accumulated in various neurodegenerative disorders including prion diseases. In our recent study [Speldewinde et al. Mol. Biol. Cell. (2015)] we used the well-established yeast [PSI+]/Sup35 and [PIN+]/Rnq1 prion models to show that autophagy prevents sporadic prion formation. Importantly, we found that spermidine, a polyamine that has been used to increase autophagic flux, acts as a protective agent which prevents spontaneous prion formation. |
| format | Article |
| id | doaj-art-afab122279a34da4a3e71b444046a55b |
| institution | DOAJ |
| issn | 2311-2638 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-afab122279a34da4a3e71b444046a55b2025-08-20T02:53:21ZengShared Science Publishers OGMicrobial Cell2311-26382015-12-0131464810.15698/mic2016.01.474Spermidine cures yeast of prionsShaun H. Speldewinde0Chris M. Grant1University of Manchester, Faculty of Life Sciences, The Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.University of Manchester, Faculty of Life Sciences, The Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.Prions are self-perpetuating amyloid protein aggregates which underlie various neurodegenerative diseases in mammals. The molecular basis underlying their conversion from a normally soluble protein into the prion form remains largely unknown. Studies aimed at uncovering these mechanism(s) are therefore essential if we are to develop effective therapeutic strategies to counteract these disease-causing entities. Autophagy is a cellular degradation system which has predominantly been considered as a non-selective bulk degradation process which recycles macromolecules in response to starvation conditions. We now know that autophagy also serves as a protein quality control mechanism which selectively degrades protein aggregates and damaged organelles. These are commonly accumulated in various neurodegenerative disorders including prion diseases. In our recent study [Speldewinde et al. Mol. Biol. Cell. (2015)] we used the well-established yeast [PSI+]/Sup35 and [PIN+]/Rnq1 prion models to show that autophagy prevents sporadic prion formation. Importantly, we found that spermidine, a polyamine that has been used to increase autophagic flux, acts as a protective agent which prevents spontaneous prion formation.http://microbialcell.com/researcharticles/spermidine-cures-yeast-of-prions/autophagyoxidative stressprionsspermidineyeast |
| spellingShingle | Shaun H. Speldewinde Chris M. Grant Spermidine cures yeast of prions Microbial Cell autophagy oxidative stress prions spermidine yeast |
| title | Spermidine cures yeast of prions |
| title_full | Spermidine cures yeast of prions |
| title_fullStr | Spermidine cures yeast of prions |
| title_full_unstemmed | Spermidine cures yeast of prions |
| title_short | Spermidine cures yeast of prions |
| title_sort | spermidine cures yeast of prions |
| topic | autophagy oxidative stress prions spermidine yeast |
| url | http://microbialcell.com/researcharticles/spermidine-cures-yeast-of-prions/ |
| work_keys_str_mv | AT shaunhspeldewinde spermidinecuresyeastofprions AT chrismgrant spermidinecuresyeastofprions |