Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency
Congenital adrenal hyperplasia (CAH) describes a group of inherited autosomal recessive disorders characterized by enzyme defects in the steroidogenic pathways that lead to the biosynthesis of cortisol, aldosterone, and androgens. Chronic excessive adrenocorticotropic hormone (ACTH) stimulation may...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2012/648643 |
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| author | Nadia Charfi Mahdi Kamoun Mouna Feki Mnif Neila Mseddi Fatma Mnif Nozha Kallel Basma Ben Naceur Nabila Rekik Hela Fourati Emna Daoud Zainab Mnif Mourad Hadj Sliman Tahia Sellami-Boudawara Mohamed Abid |
| author_facet | Nadia Charfi Mahdi Kamoun Mouna Feki Mnif Neila Mseddi Fatma Mnif Nozha Kallel Basma Ben Naceur Nabila Rekik Hela Fourati Emna Daoud Zainab Mnif Mourad Hadj Sliman Tahia Sellami-Boudawara Mohamed Abid |
| author_sort | Nadia Charfi |
| collection | DOAJ |
| description | Congenital adrenal hyperplasia (CAH) describes a group of inherited autosomal recessive disorders characterized by enzyme defects in the steroidogenic pathways that lead to the biosynthesis of cortisol, aldosterone, and androgens. Chronic excessive adrenocorticotropic hormone (ACTH) stimulation may result in hyperplasia of ACTH-sensitive tissues in adrenal glands and other sites such as the testes, causing testicular masses known as testicular adrenal rest tumors (TARTs). Leydig cell tumors (LCTs) are make up a very small number of all testicular tumors and can be difficult to distinguish from TARTs. This distinction is interesting because LCTs and TARTs require different therapeutic approaches. Hereby, we present an unusual case of a 19-year-old patient with CAH due to 11β-hydroxylase deficiency, who presented with TARTs and an epididymal Leydig cell tumor. |
| format | Article |
| id | doaj-art-afa727884a2e441482589a323de24c56 |
| institution | Kabale University |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-afa727884a2e441482589a323de24c562025-02-03T01:30:59ZengWileyCase Reports in Urology2090-696X2090-69782012-01-01201210.1155/2012/648643648643Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase DeficiencyNadia Charfi0Mahdi Kamoun1Mouna Feki Mnif2Neila Mseddi3Fatma Mnif4Nozha Kallel5Basma Ben Naceur6Nabila Rekik7Hela Fourati8Emna Daoud9Zainab Mnif10Mourad Hadj Sliman11Tahia Sellami-Boudawara12Mohamed Abid13Endocrinology Department, Hedi Chaker Hospital, Sfax 3029, TunisiaEndocrinology Department, Hedi Chaker Hospital, Sfax 3029, TunisiaEndocrinology Department, Hedi Chaker Hospital, Sfax 3029, TunisiaEndocrinology Department, Hedi Chaker Hospital, Sfax 3029, TunisiaEndocrinology Department, Hedi Chaker Hospital, Sfax 3029, TunisiaEndocrinology Department, Hedi Chaker Hospital, Sfax 3029, TunisiaEndocrinology Department, Hedi Chaker Hospital, Sfax 3029, TunisiaEndocrinology Department, Hedi Chaker Hospital, Sfax 3029, TunisiaDepartment of Radiology, Hedi Chaker Hospital, Sfax 3029, TunisiaDepartment of Radiology, Hedi Chaker Hospital, Sfax 3029, TunisiaDepartment of Radiology, Hedi Chaker Hospital, Sfax 3029, TunisiaDepartment of Urology, Habib Bourguiba Hospital, Sfax 3029, TunisiaAnatomic Pathology Department, Habib Bourguiba Hospital, Sfax 3029, TunisiaEndocrinology Department, Hedi Chaker Hospital, Sfax 3029, TunisiaCongenital adrenal hyperplasia (CAH) describes a group of inherited autosomal recessive disorders characterized by enzyme defects in the steroidogenic pathways that lead to the biosynthesis of cortisol, aldosterone, and androgens. Chronic excessive adrenocorticotropic hormone (ACTH) stimulation may result in hyperplasia of ACTH-sensitive tissues in adrenal glands and other sites such as the testes, causing testicular masses known as testicular adrenal rest tumors (TARTs). Leydig cell tumors (LCTs) are make up a very small number of all testicular tumors and can be difficult to distinguish from TARTs. This distinction is interesting because LCTs and TARTs require different therapeutic approaches. Hereby, we present an unusual case of a 19-year-old patient with CAH due to 11β-hydroxylase deficiency, who presented with TARTs and an epididymal Leydig cell tumor.http://dx.doi.org/10.1155/2012/648643 |
| spellingShingle | Nadia Charfi Mahdi Kamoun Mouna Feki Mnif Neila Mseddi Fatma Mnif Nozha Kallel Basma Ben Naceur Nabila Rekik Hela Fourati Emna Daoud Zainab Mnif Mourad Hadj Sliman Tahia Sellami-Boudawara Mohamed Abid Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency Case Reports in Urology |
| title | Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency |
| title_full | Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency |
| title_fullStr | Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency |
| title_full_unstemmed | Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency |
| title_short | Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency |
| title_sort | leydig cell tumor associated with testicular adrenal rest tumors in a patient with congenital adrenal hyperplasia due to 11β hydroxylase deficiency |
| url | http://dx.doi.org/10.1155/2012/648643 |
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