Aberrant resting-state functional network centrality and cognitive impairment in unmedicated, euthymic bipolar patients
Abstract Background Cognitive impairment is prevalent in bipolar disorder (BD), and has negative impacts on functional impairments and quality of life, despite euthymic states in most individuals. The underlying neurobiological basis of cognitive impairment in BD is still unclear. Methods To further...
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2024-12-01
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| Online Access: | https://doi.org/10.1186/s12888-024-06427-2 |
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| author | Hong Li Qijin Wu Jiahui Wang Xiaobin Zhang Huihui Song Dong Wang |
| author_facet | Hong Li Qijin Wu Jiahui Wang Xiaobin Zhang Huihui Song Dong Wang |
| author_sort | Hong Li |
| collection | DOAJ |
| description | Abstract Background Cognitive impairment is prevalent in bipolar disorder (BD), and has negative impacts on functional impairments and quality of life, despite euthymic states in most individuals. The underlying neurobiological basis of cognitive impairment in BD is still unclear. Methods To further explore potential connectivity abnormalities and their associations with cognitive impairment, we conducted a degree centrality (DC) analysis and DC (seed)-based functional connectivity (FC) approach in unmedicated, euthymic individuals with BD. Our study included 34 euthymic BD patients and 35 healthy controls (HC) matched for age, gender, and education years. Results We found extensive DC changes in brain activity, with lower DC values in the left medial frontal gyrus, inferior frontal gyrus, and middle frontal gyrus, and increased DC values in the left insula, bilateral precentral gyrus, and right medial frontal gyrus in BD patients compared to HC. Furthermore, we observed positive or negative correlations between DC values of the inferior frontal gyrus, insula_L, precentral gyrus (L), precentral gyrus (R), and medial frontal gyrus and multiple-domain cognitive assessment scores. Additionally, we identified intranetwork and internetwork functional connectivity alterations in the default mode network (DMN), fronto-parietal network (FPN), and central executive network (CEN) in euthymic BD patients compared to HC. Conclusion Our findings highlight abnormal neuronal networks involving multiple frontal brain regions and thalamus, which may contribute to cognitive deficits in individuals with euthymic BD. These findings may serve as potential hallmarks of BD, contributing to a better understanding of the neural mechanism of cognitive impairment during euthymia. |
| format | Article |
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| institution | DOAJ |
| issn | 1471-244X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
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| series | BMC Psychiatry |
| spelling | doaj-art-afa40452c3e949ceb2f257eef03e1bb92025-08-20T02:53:48ZengBMCBMC Psychiatry1471-244X2024-12-0124111310.1186/s12888-024-06427-2Aberrant resting-state functional network centrality and cognitive impairment in unmedicated, euthymic bipolar patientsHong Li0Qijin Wu1Jiahui Wang2Xiaobin Zhang3Huihui Song4Dong Wang5Department of Psychiatry, the First Affiliated Hospital of Zhengzhou UniversityDepartment of Psychiatry, the First Affiliated Hospital of Zhengzhou UniversityDepartment of Psychiatry, the First Affiliated Hospital of Zhengzhou UniversityDepartment of Geriatric Psychiatry, Suzhou Mental Health Center, Suzhou Guangji Hospital, the Affiliated Guangji Hospital of Soochow UniversityDepartment of Geriatric Psychiatry, Suzhou Mental Health Center, Suzhou Guangji Hospital, the Affiliated Guangji Hospital of Soochow UniversityDepartment of Geriatric Psychiatry, Suzhou Mental Health Center, Suzhou Guangji Hospital, the Affiliated Guangji Hospital of Soochow UniversityAbstract Background Cognitive impairment is prevalent in bipolar disorder (BD), and has negative impacts on functional impairments and quality of life, despite euthymic states in most individuals. The underlying neurobiological basis of cognitive impairment in BD is still unclear. Methods To further explore potential connectivity abnormalities and their associations with cognitive impairment, we conducted a degree centrality (DC) analysis and DC (seed)-based functional connectivity (FC) approach in unmedicated, euthymic individuals with BD. Our study included 34 euthymic BD patients and 35 healthy controls (HC) matched for age, gender, and education years. Results We found extensive DC changes in brain activity, with lower DC values in the left medial frontal gyrus, inferior frontal gyrus, and middle frontal gyrus, and increased DC values in the left insula, bilateral precentral gyrus, and right medial frontal gyrus in BD patients compared to HC. Furthermore, we observed positive or negative correlations between DC values of the inferior frontal gyrus, insula_L, precentral gyrus (L), precentral gyrus (R), and medial frontal gyrus and multiple-domain cognitive assessment scores. Additionally, we identified intranetwork and internetwork functional connectivity alterations in the default mode network (DMN), fronto-parietal network (FPN), and central executive network (CEN) in euthymic BD patients compared to HC. Conclusion Our findings highlight abnormal neuronal networks involving multiple frontal brain regions and thalamus, which may contribute to cognitive deficits in individuals with euthymic BD. These findings may serve as potential hallmarks of BD, contributing to a better understanding of the neural mechanism of cognitive impairment during euthymia.https://doi.org/10.1186/s12888-024-06427-2Bipolar disorderResting-state fMRIFunctional connectivityDegree centralityCognitive functionBrain network |
| spellingShingle | Hong Li Qijin Wu Jiahui Wang Xiaobin Zhang Huihui Song Dong Wang Aberrant resting-state functional network centrality and cognitive impairment in unmedicated, euthymic bipolar patients BMC Psychiatry Bipolar disorder Resting-state fMRI Functional connectivity Degree centrality Cognitive function Brain network |
| title | Aberrant resting-state functional network centrality and cognitive impairment in unmedicated, euthymic bipolar patients |
| title_full | Aberrant resting-state functional network centrality and cognitive impairment in unmedicated, euthymic bipolar patients |
| title_fullStr | Aberrant resting-state functional network centrality and cognitive impairment in unmedicated, euthymic bipolar patients |
| title_full_unstemmed | Aberrant resting-state functional network centrality and cognitive impairment in unmedicated, euthymic bipolar patients |
| title_short | Aberrant resting-state functional network centrality and cognitive impairment in unmedicated, euthymic bipolar patients |
| title_sort | aberrant resting state functional network centrality and cognitive impairment in unmedicated euthymic bipolar patients |
| topic | Bipolar disorder Resting-state fMRI Functional connectivity Degree centrality Cognitive function Brain network |
| url | https://doi.org/10.1186/s12888-024-06427-2 |
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