Fabrication of pullulan/Syzygium kanarense-ZnO nanocomposite films for effective topical treatment of diabetes-induced wounds
In this study Zinc oxide nanoparticles (ZnONPs) were synthesized via co-precipitation using aqueous Syzygium kanarense (Sk) leaf extract, followed by successful fabrication of pullulan/Sk-ZnONPs composites. UV-Vis spectroscopy unveiled absorption peaks at 362 nm for Sk-ZnONPs and 217 nm for pullulan...
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Elsevier
2025-01-01
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| Series: | Next Nanotechnology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949829525000452 |
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| author | Avinash Arasidda Kamble BK Sarojini MS Divakar Vinuta Kamat Delicia Avilla Barretto Raju Krishna Chalannavar Anjanapura V. Raghu |
| author_facet | Avinash Arasidda Kamble BK Sarojini MS Divakar Vinuta Kamat Delicia Avilla Barretto Raju Krishna Chalannavar Anjanapura V. Raghu |
| author_sort | Avinash Arasidda Kamble |
| collection | DOAJ |
| description | In this study Zinc oxide nanoparticles (ZnONPs) were synthesized via co-precipitation using aqueous Syzygium kanarense (Sk) leaf extract, followed by successful fabrication of pullulan/Sk-ZnONPs composites. UV-Vis spectroscopy unveiled absorption peaks at 362 nm for Sk-ZnONPs and 217 nm for pullulan. FE-SEM confirmed rod-shaped nanoparticles integrated into the pullulan matrix, while PXRD aligned with ZnO ICDD reference, revealing a crystallite size of 36.89 nm and 71.2 % crystallinity. EDX and FT-IR analyses highlighted phytochemical roles in reducing and stabilizing ZnONPs. Water contact angle measurements indicated reduced hydrophilicity of the pullulan matrix upon Sk-ZnONPs doping. The nanocomposite exhibited potent antibacterial activity, antioxidant activity (IC50: 18.97 ± 0.28 µg, comparable to ascorbic acid), anti-inflammatory effects (IC50: 17.81 ± 0.98 µg, surpassing diclofenac sodium), and antidiabetic potential (α-amylase IC50: 16.59 ± 0.45 µg; α-glucosidase inhibition: 98.95 ± 0.57 %, rivaling acarbose). These results underscore the eco-friendly potential of pullulan/Sk-ZnONPs for topical treatments for diabetes-induced wounds, offering a sustainable alternative to conventional methods. |
| format | Article |
| id | doaj-art-afa32e7daa2840759343af60ad8a5d5e |
| institution | OA Journals |
| issn | 2949-8295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Next Nanotechnology |
| spelling | doaj-art-afa32e7daa2840759343af60ad8a5d5e2025-08-20T02:36:26ZengElsevierNext Nanotechnology2949-82952025-01-01710017610.1016/j.nxnano.2025.100176Fabrication of pullulan/Syzygium kanarense-ZnO nanocomposite films for effective topical treatment of diabetes-induced woundsAvinash Arasidda Kamble0BK Sarojini1MS Divakar2Vinuta Kamat3Delicia Avilla Barretto4Raju Krishna Chalannavar5Anjanapura V. Raghu6Department of Industrial Chemistry, Mangalore University, Mangalagangotri, Karnataka 574199, IndiaDepartment of Industrial Chemistry, Mangalore University, Mangalagangotri, Karnataka 574199, IndiaBiotechnology, Department of Biosciences, Mangalore University, Mangalagangotri, Karnataka 574199, IndiaDepartment of Chemistry, Dayananda Sagar College of Engineering, Bangalore 560078, IndiaDepartment of Biochemistry, School of Chemical Sciences, Goa University, 403206, IndiaDepartment of Applied Botany, Mangalore University, Mangalagangotri, Karnataka 574199, India; Corresponding authors.Department of Chemistry, Faculty of Engineering, Dayananda Sagar University, Bangalore 562112, India; Corresponding authors.In this study Zinc oxide nanoparticles (ZnONPs) were synthesized via co-precipitation using aqueous Syzygium kanarense (Sk) leaf extract, followed by successful fabrication of pullulan/Sk-ZnONPs composites. UV-Vis spectroscopy unveiled absorption peaks at 362 nm for Sk-ZnONPs and 217 nm for pullulan. FE-SEM confirmed rod-shaped nanoparticles integrated into the pullulan matrix, while PXRD aligned with ZnO ICDD reference, revealing a crystallite size of 36.89 nm and 71.2 % crystallinity. EDX and FT-IR analyses highlighted phytochemical roles in reducing and stabilizing ZnONPs. Water contact angle measurements indicated reduced hydrophilicity of the pullulan matrix upon Sk-ZnONPs doping. The nanocomposite exhibited potent antibacterial activity, antioxidant activity (IC50: 18.97 ± 0.28 µg, comparable to ascorbic acid), anti-inflammatory effects (IC50: 17.81 ± 0.98 µg, surpassing diclofenac sodium), and antidiabetic potential (α-amylase IC50: 16.59 ± 0.45 µg; α-glucosidase inhibition: 98.95 ± 0.57 %, rivaling acarbose). These results underscore the eco-friendly potential of pullulan/Sk-ZnONPs for topical treatments for diabetes-induced wounds, offering a sustainable alternative to conventional methods.http://www.sciencedirect.com/science/article/pii/S2949829525000452Green synthesisPullulanZinc oxide nanoparticlesAntioxidantAnti-inflammatoryAntibacterial |
| spellingShingle | Avinash Arasidda Kamble BK Sarojini MS Divakar Vinuta Kamat Delicia Avilla Barretto Raju Krishna Chalannavar Anjanapura V. Raghu Fabrication of pullulan/Syzygium kanarense-ZnO nanocomposite films for effective topical treatment of diabetes-induced wounds Next Nanotechnology Green synthesis Pullulan Zinc oxide nanoparticles Antioxidant Anti-inflammatory Antibacterial |
| title | Fabrication of pullulan/Syzygium kanarense-ZnO nanocomposite films for effective topical treatment of diabetes-induced wounds |
| title_full | Fabrication of pullulan/Syzygium kanarense-ZnO nanocomposite films for effective topical treatment of diabetes-induced wounds |
| title_fullStr | Fabrication of pullulan/Syzygium kanarense-ZnO nanocomposite films for effective topical treatment of diabetes-induced wounds |
| title_full_unstemmed | Fabrication of pullulan/Syzygium kanarense-ZnO nanocomposite films for effective topical treatment of diabetes-induced wounds |
| title_short | Fabrication of pullulan/Syzygium kanarense-ZnO nanocomposite films for effective topical treatment of diabetes-induced wounds |
| title_sort | fabrication of pullulan syzygium kanarense zno nanocomposite films for effective topical treatment of diabetes induced wounds |
| topic | Green synthesis Pullulan Zinc oxide nanoparticles Antioxidant Anti-inflammatory Antibacterial |
| url | http://www.sciencedirect.com/science/article/pii/S2949829525000452 |
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