Bulk- and single cell-RNA sequencing reveal KIF20A as a key driver of hepatocellular carcinoma progression and immune evasion

Bulk- and single cell-RNA sequencing reveal KIF20A as a key driver of hepatocellular carcinoma progression and immune evasion

IntroductionKinesin family member 20A (KIF20A) is essential for cell proliferation and is implicated in promoting tumor progression, but its role in hepatocellular carcinoma (HCC) remains poorly studied.MethodsThrough the analysis of bulk RNA-sequencing (bulk RNA-seq) and single-cell RNA sequencing...

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Bibliographic Details
Main Authors: Zhixiong Su, Yaqi Zhong, Yufang He, Lijie You, Fuli Xin, Lei Wang, Zhihua Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
hepatocellular carcinoma
kinesin family member 20a
single cell RNA sequence
t cell exhaustion
immune check-point inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1469827/full
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