Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization
Immunosenescence comprises a set of dynamic changes occurring in innate and adaptive immune systems, and macrophage aging plays an important role in innate and adaptive immunosenescence. However, function and polarization changes in aging macrophages have not been fully evaluated, and no effective m...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/4657928 |
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| author | Da-yong Zhang Zheng-yang Pan Xiong-kai Yu Yi-fan Chen Chen-hao Gao Yu-tian Yang Xue-fan Jiang Na Li Jian-ping Pan |
| author_facet | Da-yong Zhang Zheng-yang Pan Xiong-kai Yu Yi-fan Chen Chen-hao Gao Yu-tian Yang Xue-fan Jiang Na Li Jian-ping Pan |
| author_sort | Da-yong Zhang |
| collection | DOAJ |
| description | Immunosenescence comprises a set of dynamic changes occurring in innate and adaptive immune systems, and macrophage aging plays an important role in innate and adaptive immunosenescence. However, function and polarization changes in aging macrophages have not been fully evaluated, and no effective method for delaying macrophage senescence is currently available. The results of this study reveal that D-galactose (D-gal) can promote J774A.1 macrophage senescence and induce macrophage M1 polarization differentiation. Bifidobacterium lactis BB-12 can significantly inhibit J774A.1 macrophage senescence induced by D-gal. IL-6 and IL-12 levels in the BB-12 groups remarkably decreased compared with that in the D-gal group, and the M2 marker, IL-10, and Arg-1 mRNA levels increased in the BB-12 group. BB-12 inhibited the expression of p-signal transducer and activator of transcription 1 (STAT1) and promoted p-STAT6 expression. In summary, the present study indicates that BB-12 can attenuate the J774A.1 macrophage senescence and induce M2 macrophage polarization, thereby indicating the potential of BB-12 to slow down immunosenescence and inflamm-aging. |
| format | Article |
| id | doaj-art-af9783ab7a0f4e65ac3b29bf3da10730 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-af9783ab7a0f4e65ac3b29bf3da107302025-08-20T03:39:05ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/46579284657928Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage PolarizationDa-yong Zhang0Zheng-yang Pan1Xiong-kai Yu2Yi-fan Chen3Chen-hao Gao4Yu-tian Yang5Xue-fan Jiang6Na Li7Jian-ping Pan8Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaDepartment of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaDepartment of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaDepartment of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaDepartment of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaDepartment of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaDepartment of Otorhinolaryngology, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang 310014, ChinaDepartment of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaDepartment of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaImmunosenescence comprises a set of dynamic changes occurring in innate and adaptive immune systems, and macrophage aging plays an important role in innate and adaptive immunosenescence. However, function and polarization changes in aging macrophages have not been fully evaluated, and no effective method for delaying macrophage senescence is currently available. The results of this study reveal that D-galactose (D-gal) can promote J774A.1 macrophage senescence and induce macrophage M1 polarization differentiation. Bifidobacterium lactis BB-12 can significantly inhibit J774A.1 macrophage senescence induced by D-gal. IL-6 and IL-12 levels in the BB-12 groups remarkably decreased compared with that in the D-gal group, and the M2 marker, IL-10, and Arg-1 mRNA levels increased in the BB-12 group. BB-12 inhibited the expression of p-signal transducer and activator of transcription 1 (STAT1) and promoted p-STAT6 expression. In summary, the present study indicates that BB-12 can attenuate the J774A.1 macrophage senescence and induce M2 macrophage polarization, thereby indicating the potential of BB-12 to slow down immunosenescence and inflamm-aging.http://dx.doi.org/10.1155/2019/4657928 |
| spellingShingle | Da-yong Zhang Zheng-yang Pan Xiong-kai Yu Yi-fan Chen Chen-hao Gao Yu-tian Yang Xue-fan Jiang Na Li Jian-ping Pan Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization Journal of Immunology Research |
| title | Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization |
| title_full | Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization |
| title_fullStr | Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization |
| title_full_unstemmed | Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization |
| title_short | Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization |
| title_sort | bifidobacterium lactis bb 12 attenuates macrophage aging induced by d galactose and promotes m2 macrophage polarization |
| url | http://dx.doi.org/10.1155/2019/4657928 |
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