Systemic administration of induced pluripotent stem cell-derived mesenchymal stem cells improves cardiac function through extracellular vesicle-mediated tissue repair in a rat model of ischemic cardiomyopathy

Systemic administration of induced pluripotent stem cell-derived mesenchymal stem cells improves cardiac function through extracellular vesicle-mediated tissue repair in a rat model of ischemic cardiomyopathy

Introduction: Systemic administration of induced pluripotent stem cell-derived mesenchymal stem cells (iPS-MSCs) has a therapeutic effect on myocardial ischemia. However, the therapeutic mechanism underlying systemic iPS-MSC-based therapy for ischemic cardiomyopathy (ICM) remains unclear. We investi...

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Bibliographic Details
Main Authors: Ryo Kawasumi, Takuji Kawamura, Kizuku Yamashita, Yuji Tominaga, Akima Harada, Emiko Ito, Maki Takeda, Shunbun Kita, Iichiro Shimomura, Shigeru Miyagawa
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Regenerative Therapy
Subjects:
Ischemic cardiomyopathy
Pluripotent stem cell
Extracellular vesicles
microRNA
Left ventricular ejection fraction
Online Access:http://www.sciencedirect.com/science/article/pii/S235232042400230X
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