Association between cardiovascular health and markers of liver function: a cross-sectional study from NHANES 2005–2018
BackgroundCardiovascular health (CVH) has been associated with various systemic diseases. However, the relationship between CVH, as measured by Life’s Essential 8 (LE8), and liver function markers in the general population remains poorly understood.MethodsThis study analyzed data from 21,156 partici...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1538654/full |
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| author | Huang Yu Tingyi Zhang Yankun Liu Wang Wang Ziyi Guan Ping Li |
| author_facet | Huang Yu Tingyi Zhang Yankun Liu Wang Wang Ziyi Guan Ping Li |
| author_sort | Huang Yu |
| collection | DOAJ |
| description | BackgroundCardiovascular health (CVH) has been associated with various systemic diseases. However, the relationship between CVH, as measured by Life’s Essential 8 (LE8), and liver function markers in the general population remains poorly understood.MethodsThis study analyzed data from 21,156 participants (aged ≥ 20) from the NHANES 2005–2018 to investigate the associations between CVH and liver function markers [alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), albumin and AST/ALT ratio]. Linear regression models were used, along with a restricted cubic spline (RCS) to assess dose-response. Weighted quantile sum (WQS) regression and quantile g-computation (QGC) analyses were employed to evaluate the association between CVH and liver function markers.ResultsLinear regression analysis showed that each 1-point increase in CVH score was significantly associated with decreased levels of liver enzymes [ALT: −0.200 U/L (95% CI: −0.223, −0.176), AST: −0.043 U/L (−0.062, −0.024), GGT: −0.453 U/L (−0.509, −0.397), ALP: −0.310 U/L (−0.340, −0.281)] and increased levels of albumin [0.040 g/dL (0.036, 0.045)] and AST/ALT ratio [0.0056 (0.0051, 0.0061)]. Notably, CVH score demonstrated non-linear dose-response relationships with ALT, ALP, and AST/ALT ratio. Age significantly modified these associations, while nicotine exposure, BMI, and blood lipids were identified as primary contributors through WQS and QGC analyses. E-value analysis suggested robustness to unmeasured confounding.ConclusionThis study demonstrates robust associations between CVH and liver function markers in United States adults, with nicotine exposure, BMI, and blood lipids identified as significant contributors. These findings suggest that maintaining optimal cardiovascular health may have beneficial effects on liver function, highlighting potential targets for integrated prevention strategies. |
| format | Article |
| id | doaj-art-af8d3016fdcd4622a89290e234d3204d |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-af8d3016fdcd4622a89290e234d3204d2025-08-20T02:04:28ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-03-011210.3389/fmed.2025.15386541538654Association between cardiovascular health and markers of liver function: a cross-sectional study from NHANES 2005–2018Huang YuTingyi ZhangYankun LiuWang WangZiyi GuanPing LiBackgroundCardiovascular health (CVH) has been associated with various systemic diseases. However, the relationship between CVH, as measured by Life’s Essential 8 (LE8), and liver function markers in the general population remains poorly understood.MethodsThis study analyzed data from 21,156 participants (aged ≥ 20) from the NHANES 2005–2018 to investigate the associations between CVH and liver function markers [alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), albumin and AST/ALT ratio]. Linear regression models were used, along with a restricted cubic spline (RCS) to assess dose-response. Weighted quantile sum (WQS) regression and quantile g-computation (QGC) analyses were employed to evaluate the association between CVH and liver function markers.ResultsLinear regression analysis showed that each 1-point increase in CVH score was significantly associated with decreased levels of liver enzymes [ALT: −0.200 U/L (95% CI: −0.223, −0.176), AST: −0.043 U/L (−0.062, −0.024), GGT: −0.453 U/L (−0.509, −0.397), ALP: −0.310 U/L (−0.340, −0.281)] and increased levels of albumin [0.040 g/dL (0.036, 0.045)] and AST/ALT ratio [0.0056 (0.0051, 0.0061)]. Notably, CVH score demonstrated non-linear dose-response relationships with ALT, ALP, and AST/ALT ratio. Age significantly modified these associations, while nicotine exposure, BMI, and blood lipids were identified as primary contributors through WQS and QGC analyses. E-value analysis suggested robustness to unmeasured confounding.ConclusionThis study demonstrates robust associations between CVH and liver function markers in United States adults, with nicotine exposure, BMI, and blood lipids identified as significant contributors. These findings suggest that maintaining optimal cardiovascular health may have beneficial effects on liver function, highlighting potential targets for integrated prevention strategies.https://www.frontiersin.org/articles/10.3389/fmed.2025.1538654/fullCVHliver functionNHANEScross-sectional studyrelationship |
| spellingShingle | Huang Yu Tingyi Zhang Yankun Liu Wang Wang Ziyi Guan Ping Li Association between cardiovascular health and markers of liver function: a cross-sectional study from NHANES 2005–2018 Frontiers in Medicine CVH liver function NHANES cross-sectional study relationship |
| title | Association between cardiovascular health and markers of liver function: a cross-sectional study from NHANES 2005–2018 |
| title_full | Association between cardiovascular health and markers of liver function: a cross-sectional study from NHANES 2005–2018 |
| title_fullStr | Association between cardiovascular health and markers of liver function: a cross-sectional study from NHANES 2005–2018 |
| title_full_unstemmed | Association between cardiovascular health and markers of liver function: a cross-sectional study from NHANES 2005–2018 |
| title_short | Association between cardiovascular health and markers of liver function: a cross-sectional study from NHANES 2005–2018 |
| title_sort | association between cardiovascular health and markers of liver function a cross sectional study from nhanes 2005 2018 |
| topic | CVH liver function NHANES cross-sectional study relationship |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1538654/full |
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