International Registry of thyroid cancer in Latin American (CaTaLiNA): epidemiology, clinical and follow-up study protocol in Latin American countries during the period 2023–2028
Introduction Differentiated thyroid cancer (DTC) is the most common endocrine malignancy, with a high 5-year survival rate of approximately 98%. Despite advances in diagnosis and treatment, up to 20% of patients experience recurrence, adversely affecting their quality of life. Predictive models have...
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2025-06-01
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| author | Juan P Brito Cristhian Garcia Percy Soto-Becerra Paola Solis Pazmino Eduardo Pilatuna Mario Ron Tannya Ledesma Benjamin Alvarado Tatiana Rojas Camila Pazmino Belen Tite Luis Figueroa Eddy Lincango Victor Hernandez Jorge Salazar Daniela Rosero Jose Guerrero Lisbeth Ruilova Luis Imaicela Hamilton Abad Jose Paz-Ibarra Camilo Gonzalez Antonio Palacios Virgilio Zanella Yosef Nasseri Jason Cohen Oscar J Ponce- Ponte |
| author_facet | Juan P Brito Cristhian Garcia Percy Soto-Becerra Paola Solis Pazmino Eduardo Pilatuna Mario Ron Tannya Ledesma Benjamin Alvarado Tatiana Rojas Camila Pazmino Belen Tite Luis Figueroa Eddy Lincango Victor Hernandez Jorge Salazar Daniela Rosero Jose Guerrero Lisbeth Ruilova Luis Imaicela Hamilton Abad Jose Paz-Ibarra Camilo Gonzalez Antonio Palacios Virgilio Zanella Yosef Nasseri Jason Cohen Oscar J Ponce- Ponte |
| author_sort | Juan P Brito |
| collection | DOAJ |
| description | Introduction Differentiated thyroid cancer (DTC) is the most common endocrine malignancy, with a high 5-year survival rate of approximately 98%. Despite advances in diagnosis and treatment, up to 20% of patients experience recurrence, adversely affecting their quality of life. Predictive models have been developed to assess recurrence risk and guide clinical decision-making, but these models often face limitations such as retrospective design, lack of diversity in study populations and absence of external validation. The primary aim is to externally validate existing predictive models for DTC recurrence using prospective data from a diverse Latin American cohort. The secondary aim is to explore opportunities for model recalibration to improve their performance in our population.Methods and analysis The CaTaLiNA study is a multicentre prospective observational study conducted across 10 hospitals in five Latin American countries, including Ecuador, Peru, Uruguay and Mexico. Patients aged 18 years or older receiving treatment for DTC, such as the first thyroid surgery, active surveillance or radiofrequency ablation will be included. Recruitment will occur from November 2023 to June 2025, with follow-up extending until June 2028. Data collection will include baseline clinical, surgical and histological characteristics, treatment details and follow-up outcomes. Statistical analysis will follow the Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis guidelines, using imputation strategies for missing data and evaluating calibration and discrimination of the prediction models. Calibration measures include the ratio of expected and observed events, calibration slope and calibration plot, while discrimination will be assessed using the C-index and area under the receiver operating characteristic curve.Ethics and dissemination This study protocol was approved by Comité de Ética de Investigación en Seres Humanos de la Universidad San Francisco de Quito USFQ ‘CEISH-USFQ’ APO-010–2023-CEIHS-USFQ Oficio No. 161-2023-CA-23030M-CEISH-USFQ. Results will be disseminated via peer-reviewed publications. |
| format | Article |
| id | doaj-art-af8a4b6db1bf421b9cd0791165272112 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMJ Publishing Group |
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| spelling | doaj-art-af8a4b6db1bf421b9cd07911652721122025-08-20T03:30:03ZengBMJ Publishing GroupBMJ Open2044-60552025-06-0115610.1136/bmjopen-2024-093471International Registry of thyroid cancer in Latin American (CaTaLiNA): epidemiology, clinical and follow-up study protocol in Latin American countries during the period 2023–2028Juan P Brito0Cristhian Garcia1Percy Soto-Becerra2Paola Solis Pazmino3Eduardo Pilatuna4Mario Ron5Tannya Ledesma6Benjamin Alvarado7Tatiana Rojas8Camila Pazmino9Belen Tite10Luis Figueroa11Eddy Lincango12Victor Hernandez13Jorge Salazar14Daniela Rosero15Jose Guerrero16Lisbeth Ruilova17Luis Imaicela18Hamilton Abad19Jose Paz-Ibarra20Camilo Gonzalez21Antonio Palacios22Virgilio Zanella23Yosef Nasseri24Jason Cohen25Oscar J Ponce- Ponte26Division of Endocrinology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USAHead and Neck Surgery Department, Instituto de la Tiroides y Enfermedades de Cabeza y Cuello (ITECC), Quito, EcuadorCentro de Innovación e Investigación Traslacional en Salud, Universidad Privada del Norte, Lima, PeruCaTaLiNA- Cancer de Tiroides en Latino América, Quito, EcuadorCaTaLiNA- Cancer de Tiroides en Latino América, Quito, EcuadorSociedad de Lucha Contra el Cancer- SOLCA, Quito, EcuadorMedical School, Universidad Central del Ecuador, Quito, EcuadorCaTaLiNA- Cancer de Tiroides en Latino América, Quito, EcuadorCaTaLiNA- Cancer de Tiroides en Latino América, Quito, EcuadorCaTaLiNA- Cancer de Tiroides en Latino América, Quito, EcuadorCaTaLiNA- Cancer de Tiroides en Latino América, Quito, EcuadorCaTaLiNA- Cancer de Tiroides en Latino América, Quito, EcuadorCaTaLiNA- Cancer de Tiroides en Latino América, Quito, EcuadorSurgery Department, Hospital Regional Ambato, Ambato, EcuadorEndocrinology Department, Hospital Eugenio Espejo, Quito, EcuadorSociedad de Lucha Contra el Cancer- SOLCA, Quito, EcuadorSociedad de Lucha Contra el Cancer- SOLCA, Quito, EcuadorSociedad de Lucha Contra el Cancer- SOLCA, Cuenca, EcuadorSociedad de Lucha Contra el Cancer- SOLCA, Guayaquil, EcuadorSociedad de Lucha Contra el Cancer- SOLCA, Guayaquil, EcuadorEndocrinology Department, Hospital Nacional Edgardo Rebagliati Martins, Lima, PeruTHANC (Thyroid, Head and Neck Cancer) Foundation, New York, New York, USAHead and Neck Surgery Department, Hospital Eugenio Espejo, Quito, EcuadorHead and Neck Surgery Department, Hospital Santa Rita, Santa Casa, Porto Alegre, BrazilSurgery Group Los Angeles, Los Angeles, California, USASurgery Group Los Angeles, Los Angeles, California, USACaTaLiNA- Cancer de Tiroides en Latino América, Quito, EcuadorIntroduction Differentiated thyroid cancer (DTC) is the most common endocrine malignancy, with a high 5-year survival rate of approximately 98%. Despite advances in diagnosis and treatment, up to 20% of patients experience recurrence, adversely affecting their quality of life. Predictive models have been developed to assess recurrence risk and guide clinical decision-making, but these models often face limitations such as retrospective design, lack of diversity in study populations and absence of external validation. The primary aim is to externally validate existing predictive models for DTC recurrence using prospective data from a diverse Latin American cohort. The secondary aim is to explore opportunities for model recalibration to improve their performance in our population.Methods and analysis The CaTaLiNA study is a multicentre prospective observational study conducted across 10 hospitals in five Latin American countries, including Ecuador, Peru, Uruguay and Mexico. Patients aged 18 years or older receiving treatment for DTC, such as the first thyroid surgery, active surveillance or radiofrequency ablation will be included. Recruitment will occur from November 2023 to June 2025, with follow-up extending until June 2028. Data collection will include baseline clinical, surgical and histological characteristics, treatment details and follow-up outcomes. Statistical analysis will follow the Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis guidelines, using imputation strategies for missing data and evaluating calibration and discrimination of the prediction models. Calibration measures include the ratio of expected and observed events, calibration slope and calibration plot, while discrimination will be assessed using the C-index and area under the receiver operating characteristic curve.Ethics and dissemination This study protocol was approved by Comité de Ética de Investigación en Seres Humanos de la Universidad San Francisco de Quito USFQ ‘CEISH-USFQ’ APO-010–2023-CEIHS-USFQ Oficio No. 161-2023-CA-23030M-CEISH-USFQ. Results will be disseminated via peer-reviewed publications.https://bmjopen.bmj.com/content/15/6/e093471.full |
| spellingShingle | Juan P Brito Cristhian Garcia Percy Soto-Becerra Paola Solis Pazmino Eduardo Pilatuna Mario Ron Tannya Ledesma Benjamin Alvarado Tatiana Rojas Camila Pazmino Belen Tite Luis Figueroa Eddy Lincango Victor Hernandez Jorge Salazar Daniela Rosero Jose Guerrero Lisbeth Ruilova Luis Imaicela Hamilton Abad Jose Paz-Ibarra Camilo Gonzalez Antonio Palacios Virgilio Zanella Yosef Nasseri Jason Cohen Oscar J Ponce- Ponte International Registry of thyroid cancer in Latin American (CaTaLiNA): epidemiology, clinical and follow-up study protocol in Latin American countries during the period 2023–2028 BMJ Open |
| title | International Registry of thyroid cancer in Latin American (CaTaLiNA): epidemiology, clinical and follow-up study protocol in Latin American countries during the period 2023–2028 |
| title_full | International Registry of thyroid cancer in Latin American (CaTaLiNA): epidemiology, clinical and follow-up study protocol in Latin American countries during the period 2023–2028 |
| title_fullStr | International Registry of thyroid cancer in Latin American (CaTaLiNA): epidemiology, clinical and follow-up study protocol in Latin American countries during the period 2023–2028 |
| title_full_unstemmed | International Registry of thyroid cancer in Latin American (CaTaLiNA): epidemiology, clinical and follow-up study protocol in Latin American countries during the period 2023–2028 |
| title_short | International Registry of thyroid cancer in Latin American (CaTaLiNA): epidemiology, clinical and follow-up study protocol in Latin American countries during the period 2023–2028 |
| title_sort | international registry of thyroid cancer in latin american catalina epidemiology clinical and follow up study protocol in latin american countries during the period 2023 2028 |
| url | https://bmjopen.bmj.com/content/15/6/e093471.full |
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