Depression Prior to Dementia: Examining Its Role as a Risk Factor, Prodromal Marker, or Confounding Comorbidity: A Synthesis of Current Research

Aims: The relationship between depression and dementia represents a complex clinical phenomenon that continues to challenge our understanding of neurodegenerative disease progression. This review synthesizes the most recent evidence examining whether depression serves as a risk factor, prodromal mar...

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Main Authors: Virginia Johnson, Calvin Flowers
Format: Article
Language:English
Published: Cambridge University Press 2025-06-01
Series:BJPsych Open
Online Access:https://www.cambridge.org/core/product/identifier/S2056472425101269/type/journal_article
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author Virginia Johnson
Calvin Flowers
author_facet Virginia Johnson
Calvin Flowers
author_sort Virginia Johnson
collection DOAJ
description Aims: The relationship between depression and dementia represents a complex clinical phenomenon that continues to challenge our understanding of neurodegenerative disease progression. This review synthesizes the most recent evidence examining whether depression serves as a risk factor, prodromal marker, or common confounding comorbidity in dementia development.
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institution Kabale University
issn 2056-4724
language English
publishDate 2025-06-01
publisher Cambridge University Press
record_format Article
series BJPsych Open
spelling doaj-art-af889f20e79b4de79d4de1930490d9f92025-08-20T03:32:54ZengCambridge University PressBJPsych Open2056-47242025-06-0111S35S3510.1192/bjo.2025.10126Depression Prior to Dementia: Examining Its Role as a Risk Factor, Prodromal Marker, or Confounding Comorbidity: A Synthesis of Current ResearchVirginia Johnson0Calvin Flowers1CFMD Inc, Visalia, USACFMD Inc, Visalia, USAAims: The relationship between depression and dementia represents a complex clinical phenomenon that continues to challenge our understanding of neurodegenerative disease progression. This review synthesizes the most recent evidence examining whether depression serves as a risk factor, prodromal marker, or common confounding comorbidity in dementia development.https://www.cambridge.org/core/product/identifier/S2056472425101269/type/journal_article
spellingShingle Virginia Johnson
Calvin Flowers
Depression Prior to Dementia: Examining Its Role as a Risk Factor, Prodromal Marker, or Confounding Comorbidity: A Synthesis of Current Research
BJPsych Open
title Depression Prior to Dementia: Examining Its Role as a Risk Factor, Prodromal Marker, or Confounding Comorbidity: A Synthesis of Current Research
title_full Depression Prior to Dementia: Examining Its Role as a Risk Factor, Prodromal Marker, or Confounding Comorbidity: A Synthesis of Current Research
title_fullStr Depression Prior to Dementia: Examining Its Role as a Risk Factor, Prodromal Marker, or Confounding Comorbidity: A Synthesis of Current Research
title_full_unstemmed Depression Prior to Dementia: Examining Its Role as a Risk Factor, Prodromal Marker, or Confounding Comorbidity: A Synthesis of Current Research
title_short Depression Prior to Dementia: Examining Its Role as a Risk Factor, Prodromal Marker, or Confounding Comorbidity: A Synthesis of Current Research
title_sort depression prior to dementia examining its role as a risk factor prodromal marker or confounding comorbidity a synthesis of current research
url https://www.cambridge.org/core/product/identifier/S2056472425101269/type/journal_article
work_keys_str_mv AT virginiajohnson depressionpriortodementiaexaminingitsroleasariskfactorprodromalmarkerorconfoundingcomorbidityasynthesisofcurrentresearch
AT calvinflowers depressionpriortodementiaexaminingitsroleasariskfactorprodromalmarkerorconfoundingcomorbidityasynthesisofcurrentresearch